The University of Southampton
University of Southampton Institutional Repository
Warning ePrints Soton is experiencing an issue with some file downloads not being available. We are working hard to fix this. Please bear with us.

Comparison of associations with different macular inner retinal thickness parameters in a large cohort: The UK Biobank

Comparison of associations with different macular inner retinal thickness parameters in a large cohort: The UK Biobank
Comparison of associations with different macular inner retinal thickness parameters in a large cohort: The UK Biobank

Purpose: To describe and compare associations with macular retinal nerve fiber layer (mRNFL), ganglion cell complex (GCC), and ganglion cell–inner plexiform layer (GCIPL) thicknesses in a large cohort. Design: Cross-sectional study. Participants: We included 42 044 participants in the UK Biobank. The mean age was 56 years. Methods: Spectral-domain OCT macular images were segmented and analyzed. Corneal-compensated intraocular pressure (IOPcc) was measured with the Ocular Response Analyzer (Reichert, Corp., Buffalo, NY). Multivariable linear regression was used to examine associations with mean mRNFL, GCC, and GCIPL thicknesses. Factors examined were age, sex, ethnicity, height, body mass index (BMI), smoking status, alcohol intake, Townsend deprivation index, education level, diabetes status, spherical equivalent, and IOPcc. Main Outcome Measures: Thicknesses of mRNFL, GCC, and GCIPL. Results: We identified several novel independent associations with thinner inner retinal thickness. Thinner inner retina was associated with alcohol intake (most significant for GCIPL: –0.46 μm for daily or almost daily intake compared with special occasion only or never [95% confidence interval (CI), 0.61–0.30]; P = 1.1×10–8), greater social deprivation (most significant for GCIPL: –0.28 μm for most deprived quartile compared with least deprived quartile [95% CI, –0.42 to –0.14]; P = 6.6×10–5), lower educational attainment (most significant for mRNFL: –0.36 μm for less than O level compared with degree level [95% CI, –0.45 to 0.26]; P = 2.3×10–14), and nonwhite ethnicity (most significant for mRNFL comparing blacks with whites: –1.65 μm [95% CI, –1.86 to –1.43]; P = 2.4×10–50). Corneal-compensated intraocular pressure was associated most significantly with GCIPL (–0.04 μm/mmHg [95% CI, –0.05 to –0.03]; P = 4.0×10–10) and was not associated significantly with mRNFL (0.00 μm/mmHg [95% CI, –0.01 to 0.01]; P = 0.77). The variables examined explained a greater proportion of the variance of GCIPL (11%) than GCC (6%) or mRNFL (7%). Conclusions: The novel associations we identified may be important to consider when using inner retinal parameters as a diagnostic tool. Associations generally were strongest with GCIPL, particularly for IOP. This suggests that GCIPL may be the superior inner retinal biomarker for macular pathophysiologic processes and especially for glaucoma.

0161-6420
Khawaja, Anthony P.
ac15cbf1-b21c-4760-80d9-d8ff7ce51e03
Chua, Sharon
b3747012-23d5-4a4b-88f0-3e71db322bee
Hysi, Pirro G.
aa3844c8-e5ac-4ebd-ad1c-56bc9c227a3d
Georgoulas, Stelios
511ce1af-70b8-4b7d-b98e-1c0f82e85492
Currant, Hannah
4df2bda9-44d6-4854-b720-e43593385a73
Fitzgerald, Tomas W.
e7a1b0ef-302e-485c-be2a-d93891f2e32c
Birney, Ewan
5f4b6bf9-e351-4cc4-923b-87a9f09845c6
Ko, Fang
6b641bad-8e8b-4ccb-b1d9-7ad05bc0d283
Yang, Qi
168ad561-796e-4575-9f33-47d33d06487f
Reisman, Charles
ce82630a-aacc-4dd1-a40e-b443a7c60144
Garway-Heath, David F.
840a1422-939a-438a-b697-d79ced8b4723
Hammond, Chris J.
6236d58c-3b17-4c57-912d-fb40bc041a70
Khaw, Peng T.
f3113e99-7283-40f9-baea-954edc3ca00c
Foster, Paul
b1c5c359-c987-4d15-8daa-044fe7326978
Patel, Praveen
91baf7b2-de1c-40aa-b3f4-7cc7007220f2
Strouthidis, Nicholas
245291a1-8ccd-4409-8f74-6dc284912c14
Atan, Denize
ee27dcf4-671c-4c31-b521-99f9db4dee21
Aslam, Tariq
6f521c61-7ff6-4153-a013-e981b99e46ed
Barman, Sarah A.
ad116fd2-8779-459a-8002-69e7e3f418a1
Barrett, Jenny H.
b82db9fa-3880-4a12-8f8c-566938e0c140
Bishop, Paul
ad344149-e2af-4ed5-8288-fa5b5ccc6d0a
Blows, Peter
7c22a4f8-bf9b-4893-af1f-bad946023cea
Bunce, Catey
6b999375-2e40-497f-8076-9435b3cba2f4
Carare, Roxana O.
0478c197-b0c1-4206-acae-54e88c8f21fa
Chakravarthy, Usha
2c06cdaf-94c0-409a-8eff-2f624c120a5e
Chan, Michelle
c57c833d-6a9d-4a60-a06d-000a27e0cfab
Chua, Sharon Y.L.
806116ec-8f79-41cb-b52b-0ad40dcaf587
Crabb, David P.
acc45817-a5fe-42ee-aff8-e2d1e42f49da
Cumberland, Philippa M.
c6034d3e-ba4c-4b88-940b-1f56a4211469
Day, Alexander
a0fcd347-ce82-4e58-ac80-c05f93f28fd9
Desai, Parul
2cec4ddd-d533-4188-933b-2b0b24ea0807
Dhillon, Bal
bf394f89-07b5-42c9-8be6-bef9bd5bd9e2
Dick, Andrew D.
3663310f-576f-459a-aa3e-7a249ab33e28
Egan, Cathy
20273940-9b84-46d6-a48e-c3f78e35ad4a
Ennis, Sarah
7b57f188-9d91-4beb-b217-09856146f1e9
Foster, Paul
b1c5c359-c987-4d15-8daa-044fe7326978
Fruttiger, Marcus
2dbf2100-30c9-4829-8bdc-d81d7eb6d0c6
Gallacher, John E.J.
e05d736b-eb13-4f6b-b8ca-6f417d60a6a7
Gibson, Jane
855033a6-38f3-4853-8f60-d7d4561226ae
Gore, Dan
4cfbfc9a-920f-4b6e-9262-4105a3a0b58c
Guggenheim, Jeremy A.
215f4513-dd43-4fba-ad93-8b3cdcfab084
Hardcastle, Alison
e4c03ff9-d55f-4afa-a8a2-17a0465dc576
Harding, Simon P.
10091207-4f52-491b-b069-98bb37444f5b
Hogg, Ruth E.
6af73eac-81f8-4fe5-a1dc-1a62e68145c4
Hysi, Pirro
ec24947f-5c59-4ffd-af5a-9d5bdf2b80ec
Keane, Pearse A.
fc1d555b-277f-45e1-ac72-727766911e6f
Khaw, Sir Peng T.
8f8bf84c-016b-4543-b9cf-71d1f83cef02
Lotery, Andrew J.
5ecc2d2d-d0b4-468f-ad2c-df7156f8e514
Morgan, James E.
391ed7a6-fadb-4127-86e6-404f80596b08
Self, Jay
0f6efc58-ae24-4667-b8d6-6fafa849e389
UK Biobank Eye and Vision Consortium
Khawaja, Anthony P.
ac15cbf1-b21c-4760-80d9-d8ff7ce51e03
Chua, Sharon
b3747012-23d5-4a4b-88f0-3e71db322bee
Hysi, Pirro G.
aa3844c8-e5ac-4ebd-ad1c-56bc9c227a3d
Georgoulas, Stelios
511ce1af-70b8-4b7d-b98e-1c0f82e85492
Currant, Hannah
4df2bda9-44d6-4854-b720-e43593385a73
Fitzgerald, Tomas W.
e7a1b0ef-302e-485c-be2a-d93891f2e32c
Birney, Ewan
5f4b6bf9-e351-4cc4-923b-87a9f09845c6
Ko, Fang
6b641bad-8e8b-4ccb-b1d9-7ad05bc0d283
Yang, Qi
168ad561-796e-4575-9f33-47d33d06487f
Reisman, Charles
ce82630a-aacc-4dd1-a40e-b443a7c60144
Garway-Heath, David F.
840a1422-939a-438a-b697-d79ced8b4723
Hammond, Chris J.
6236d58c-3b17-4c57-912d-fb40bc041a70
Khaw, Peng T.
f3113e99-7283-40f9-baea-954edc3ca00c
Foster, Paul
b1c5c359-c987-4d15-8daa-044fe7326978
Patel, Praveen
91baf7b2-de1c-40aa-b3f4-7cc7007220f2
Strouthidis, Nicholas
245291a1-8ccd-4409-8f74-6dc284912c14
Atan, Denize
ee27dcf4-671c-4c31-b521-99f9db4dee21
Aslam, Tariq
6f521c61-7ff6-4153-a013-e981b99e46ed
Barman, Sarah A.
ad116fd2-8779-459a-8002-69e7e3f418a1
Barrett, Jenny H.
b82db9fa-3880-4a12-8f8c-566938e0c140
Bishop, Paul
ad344149-e2af-4ed5-8288-fa5b5ccc6d0a
Blows, Peter
7c22a4f8-bf9b-4893-af1f-bad946023cea
Bunce, Catey
6b999375-2e40-497f-8076-9435b3cba2f4
Carare, Roxana O.
0478c197-b0c1-4206-acae-54e88c8f21fa
Chakravarthy, Usha
2c06cdaf-94c0-409a-8eff-2f624c120a5e
Chan, Michelle
c57c833d-6a9d-4a60-a06d-000a27e0cfab
Chua, Sharon Y.L.
806116ec-8f79-41cb-b52b-0ad40dcaf587
Crabb, David P.
acc45817-a5fe-42ee-aff8-e2d1e42f49da
Cumberland, Philippa M.
c6034d3e-ba4c-4b88-940b-1f56a4211469
Day, Alexander
a0fcd347-ce82-4e58-ac80-c05f93f28fd9
Desai, Parul
2cec4ddd-d533-4188-933b-2b0b24ea0807
Dhillon, Bal
bf394f89-07b5-42c9-8be6-bef9bd5bd9e2
Dick, Andrew D.
3663310f-576f-459a-aa3e-7a249ab33e28
Egan, Cathy
20273940-9b84-46d6-a48e-c3f78e35ad4a
Ennis, Sarah
7b57f188-9d91-4beb-b217-09856146f1e9
Foster, Paul
b1c5c359-c987-4d15-8daa-044fe7326978
Fruttiger, Marcus
2dbf2100-30c9-4829-8bdc-d81d7eb6d0c6
Gallacher, John E.J.
e05d736b-eb13-4f6b-b8ca-6f417d60a6a7
Gibson, Jane
855033a6-38f3-4853-8f60-d7d4561226ae
Gore, Dan
4cfbfc9a-920f-4b6e-9262-4105a3a0b58c
Guggenheim, Jeremy A.
215f4513-dd43-4fba-ad93-8b3cdcfab084
Hardcastle, Alison
e4c03ff9-d55f-4afa-a8a2-17a0465dc576
Harding, Simon P.
10091207-4f52-491b-b069-98bb37444f5b
Hogg, Ruth E.
6af73eac-81f8-4fe5-a1dc-1a62e68145c4
Hysi, Pirro
ec24947f-5c59-4ffd-af5a-9d5bdf2b80ec
Keane, Pearse A.
fc1d555b-277f-45e1-ac72-727766911e6f
Khaw, Sir Peng T.
8f8bf84c-016b-4543-b9cf-71d1f83cef02
Lotery, Andrew J.
5ecc2d2d-d0b4-468f-ad2c-df7156f8e514
Morgan, James E.
391ed7a6-fadb-4127-86e6-404f80596b08
Self, Jay
0f6efc58-ae24-4667-b8d6-6fafa849e389

UK Biobank Eye and Vision Consortium (2019) Comparison of associations with different macular inner retinal thickness parameters in a large cohort: The UK Biobank. Ophthalmology. (doi:10.1016/j.ophtha.2019.08.015).

Record type: Article

Abstract

Purpose: To describe and compare associations with macular retinal nerve fiber layer (mRNFL), ganglion cell complex (GCC), and ganglion cell–inner plexiform layer (GCIPL) thicknesses in a large cohort. Design: Cross-sectional study. Participants: We included 42 044 participants in the UK Biobank. The mean age was 56 years. Methods: Spectral-domain OCT macular images were segmented and analyzed. Corneal-compensated intraocular pressure (IOPcc) was measured with the Ocular Response Analyzer (Reichert, Corp., Buffalo, NY). Multivariable linear regression was used to examine associations with mean mRNFL, GCC, and GCIPL thicknesses. Factors examined were age, sex, ethnicity, height, body mass index (BMI), smoking status, alcohol intake, Townsend deprivation index, education level, diabetes status, spherical equivalent, and IOPcc. Main Outcome Measures: Thicknesses of mRNFL, GCC, and GCIPL. Results: We identified several novel independent associations with thinner inner retinal thickness. Thinner inner retina was associated with alcohol intake (most significant for GCIPL: –0.46 μm for daily or almost daily intake compared with special occasion only or never [95% confidence interval (CI), 0.61–0.30]; P = 1.1×10–8), greater social deprivation (most significant for GCIPL: –0.28 μm for most deprived quartile compared with least deprived quartile [95% CI, –0.42 to –0.14]; P = 6.6×10–5), lower educational attainment (most significant for mRNFL: –0.36 μm for less than O level compared with degree level [95% CI, –0.45 to 0.26]; P = 2.3×10–14), and nonwhite ethnicity (most significant for mRNFL comparing blacks with whites: –1.65 μm [95% CI, –1.86 to –1.43]; P = 2.4×10–50). Corneal-compensated intraocular pressure was associated most significantly with GCIPL (–0.04 μm/mmHg [95% CI, –0.05 to –0.03]; P = 4.0×10–10) and was not associated significantly with mRNFL (0.00 μm/mmHg [95% CI, –0.01 to 0.01]; P = 0.77). The variables examined explained a greater proportion of the variance of GCIPL (11%) than GCC (6%) or mRNFL (7%). Conclusions: The novel associations we identified may be important to consider when using inner retinal parameters as a diagnostic tool. Associations generally were strongest with GCIPL, particularly for IOP. This suggests that GCIPL may be the superior inner retinal biomarker for macular pathophysiologic processes and especially for glaucoma.

This record has no associated files available for download.

More information

Accepted/In Press date: 13 August 2019
e-pub ahead of print date: 21 August 2019

Identifiers

Local EPrints ID: 435381
URI: http://eprints.soton.ac.uk/id/eprint/435381
ISSN: 0161-6420
PURE UUID: e1073aea-c1ed-48c5-8a72-b631a3509d4e
ORCID for Roxana O. Carare: ORCID iD orcid.org/0000-0001-6458-3776
ORCID for Sarah Ennis: ORCID iD orcid.org/0000-0003-2648-0869
ORCID for Jane Gibson: ORCID iD orcid.org/0000-0002-0973-8285
ORCID for Andrew J. Lotery: ORCID iD orcid.org/0000-0001-5541-4305
ORCID for Jay Self: ORCID iD orcid.org/0000-0002-1030-9963

Catalogue record

Date deposited: 01 Nov 2019 17:30
Last modified: 26 Nov 2021 02:50

Export record

Altmetrics

Contributors

Author: Anthony P. Khawaja
Author: Sharon Chua
Author: Pirro G. Hysi
Author: Stelios Georgoulas
Author: Hannah Currant
Author: Tomas W. Fitzgerald
Author: Ewan Birney
Author: Fang Ko
Author: Qi Yang
Author: Charles Reisman
Author: David F. Garway-Heath
Author: Chris J. Hammond
Author: Peng T. Khaw
Author: Paul Foster
Author: Praveen Patel
Author: Nicholas Strouthidis
Author: Denize Atan
Author: Tariq Aslam
Author: Sarah A. Barman
Author: Jenny H. Barrett
Author: Paul Bishop
Author: Peter Blows
Author: Catey Bunce
Author: Usha Chakravarthy
Author: Michelle Chan
Author: Sharon Y.L. Chua
Author: David P. Crabb
Author: Philippa M. Cumberland
Author: Alexander Day
Author: Parul Desai
Author: Bal Dhillon
Author: Andrew D. Dick
Author: Cathy Egan
Author: Sarah Ennis ORCID iD
Author: Paul Foster
Author: Marcus Fruttiger
Author: John E.J. Gallacher
Author: Jane Gibson ORCID iD
Author: Dan Gore
Author: Jeremy A. Guggenheim
Author: Alison Hardcastle
Author: Simon P. Harding
Author: Ruth E. Hogg
Author: Pirro Hysi
Author: Pearse A. Keane
Author: Sir Peng T. Khaw
Author: James E. Morgan
Author: Jay Self ORCID iD
Corporate Author: UK Biobank Eye and Vision Consortium

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×