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The mitogenome of a 35,000-year-old Homo sapiens from Europe supports a Palaeolithic back-migration to Africa

The mitogenome of a 35,000-year-old Homo sapiens from Europe supports a Palaeolithic back-migration to Africa
The mitogenome of a 35,000-year-old Homo sapiens from Europe supports a Palaeolithic back-migration to Africa
After the dispersal of modern humans (Homo sapiens) Out of Africa, hominins with a similar morphology to that of present-day humans initiated the gradual demographic expansion into Eurasia. The mitogenome (33-fold coverage) of the Peştera Muierii 1 individual (PM1) from Romania (35 ky cal BP) we present in this article corresponds fully to Homo sapiens, whilst exhibiting a mosaic of morphological features related to both modern humans and Neandertals. We have identified the PM1 mitogenome as a basal haplogroup U6*, not previously found in any ancient or present-day humans. The derived U6 haplotypes are predominantly found in present-day North-Western African populations. Concomitantly, those found in Europe have been attributed to recent gene-flow from North Africa. The presence of the basal haplogroup U6* in South East Europe (Romania) at 35 ky BP confirms a Eurasian origin of the U6 mitochondrial lineage. Consequently, we propose that the PM1 lineage is an offshoot to South East Europe that can be traced to the Early Upper Paleolithic back migration from Western Asia to North Africa, during which the U6 lineage diversified, until the emergence of the present-day U6 African lineages.
2045-2322
Hervella, M.
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Svensson, E. M.
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Alberdi, A.
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Gunther, T.
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Izagirre, N.
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Munters, A. R.
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Alonso, S.
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Ioana, M.
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Ridiche, F.
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Soficaru, A.
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Jakobsson, M.
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Netea, M. G.
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de-la-Rua, C.
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Hervella, M.
cfa5633f-4745-4b03-8f97-3c53e55332b1
Svensson, E. M.
b18f493c-4d0a-47ed-979d-92443936de8b
Alberdi, A.
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Gunther, T.
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Izagirre, N.
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Munters, A. R.
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Alonso, S.
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Ioana, M.
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Ridiche, F.
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Soficaru, A.
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Jakobsson, M.
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Netea, M. G.
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de-la-Rua, C.
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Hervella, M., Svensson, E. M., Alberdi, A., Gunther, T., Izagirre, N., Munters, A. R., Alonso, S., Ioana, M., Ridiche, F., Soficaru, A., Jakobsson, M., Netea, M. G. and de-la-Rua, C. (2016) The mitogenome of a 35,000-year-old Homo sapiens from Europe supports a Palaeolithic back-migration to Africa. Scientific Reports, 6, [25501]. (doi:10.1038/srep25501).

Record type: Article

Abstract

After the dispersal of modern humans (Homo sapiens) Out of Africa, hominins with a similar morphology to that of present-day humans initiated the gradual demographic expansion into Eurasia. The mitogenome (33-fold coverage) of the Peştera Muierii 1 individual (PM1) from Romania (35 ky cal BP) we present in this article corresponds fully to Homo sapiens, whilst exhibiting a mosaic of morphological features related to both modern humans and Neandertals. We have identified the PM1 mitogenome as a basal haplogroup U6*, not previously found in any ancient or present-day humans. The derived U6 haplotypes are predominantly found in present-day North-Western African populations. Concomitantly, those found in Europe have been attributed to recent gene-flow from North Africa. The presence of the basal haplogroup U6* in South East Europe (Romania) at 35 ky BP confirms a Eurasian origin of the U6 mitochondrial lineage. Consequently, we propose that the PM1 lineage is an offshoot to South East Europe that can be traced to the Early Upper Paleolithic back migration from Western Asia to North Africa, during which the U6 lineage diversified, until the emergence of the present-day U6 African lineages.

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Accepted/In Press date: 19 April 2016
Published date: 19 May 2016

Identifiers

Local EPrints ID: 435525
URI: http://eprints.soton.ac.uk/id/eprint/435525
ISSN: 2045-2322
PURE UUID: edfaac35-48f0-4809-8e85-cb8fa1507fdf
ORCID for A. Soficaru: ORCID iD orcid.org/0000-0001-8658-6695

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Date deposited: 08 Nov 2019 17:30
Last modified: 07 Oct 2020 02:23

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Contributors

Author: M. Hervella
Author: E. M. Svensson
Author: A. Alberdi
Author: T. Gunther
Author: N. Izagirre
Author: A. R. Munters
Author: S. Alonso
Author: M. Ioana
Author: F. Ridiche
Author: A. Soficaru ORCID iD
Author: M. Jakobsson
Author: M. G. Netea
Author: C. de-la-Rua

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