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Long-term outcomes of urinary tract infection (UTI) in Childhood (LUCI): protocol for an electronic record-linked cohort study

Long-term outcomes of urinary tract infection (UTI) in Childhood (LUCI): protocol for an electronic record-linked cohort study
Long-term outcomes of urinary tract infection (UTI) in Childhood (LUCI): protocol for an electronic record-linked cohort study
Introduction: current guidelines advise the prompt diagnosis and treatment of urinary tract infection (UTI) in children to improve both short and longer term outcomes. However, the risk of long-term complications following childhood UTI is unclear. UTI is relatively common but difficult to diagnose in children as symptoms are non-specific. Diagnosis requires a urine sample, but sampling is difficult and infrequent, and it is not clear if sampling should be given greater priority in primary care. The LUCI study will assess the short, medium and longer term outcomes of childhood UTI associated with routine and systematic sampling practices.

Methods and analysis: two data sets will be established. The first will consist of routinely collected data (hospital, general practice (GP), microbiology) from children born and resident in Wales, linked via the Secure Anonymised Information Linkage (SAIL) Databank (an ?e-cohort?). Urine sampling in this data set reflects normal practice ?routine sampling?. Outcomes (including renal scarring, hypertension, end-stage renal failure, hospital admissions, GP consultations, antibiotic prescriptions) for children with at least one UTI confirmed with microbiological culture (mcUTI) or no mcUTI before the age of 5 will be compared. The second will combine data from two prospective observational studies (?DUTY? and ?EURICA?) employing systematic urine sampling for children presenting to primary care with acute, undifferentiated illness, linked to routine data via SAIL (Wales) and NHS Digital (England). Outcomes (as above, plus features of mcUTI) for children with an mcUTI in this data set, identified through systematic urine sampling, will be compared with those with an mcUTI identified through routine urine sampling (data set 1). Ethics and dissemination: The study protocol has been approved by NHS Wales Research Ethics Committee and the Health Research Authority?s Confidentiality Advisory Group. Methods of innovative study design and findings will be disseminated through peer-review journals and conferences. Results will be of interest to clinical and policy stakeholders in the UK.
2044-6055
Lugg-Widger, Fiona
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Angel, Lianna
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Cannings-John, Rebecca
f45c9562-b1d0-4c6d-9c7c-8f27cd3e47cd
Jones, Hywel
08149e0a-2674-423f-ba25-d16303fbe3cd
Lau, Mandy
828a2963-4975-4b74-8582-8b7cb3b961c1
Butler, Christopher C
8bf4cace-c34a-4b65-838f-29c2be91e434
Francis, Nick
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Hay, Alastair D
bfae9e44-ae9b-473c-923f-1dea50747023
Heginbothom, Margaret
dc97ef32-7d76-427d-8ab9-83d126306efb
Hood, Kerenza
af7cf839-ca85-4ea9-83c3-3dd31be88b32
Paranjothy, Shantini
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Voort, Judith Van der
d35b2ed1-6e26-4d2e-aa21-62cc637e78e6
Hughes, Kathryn
e176d8ac-a6be-4c93-b7bb-e756362e0c90
Lugg-Widger, Fiona
bd758544-0f82-4fbc-9669-11aef823dac2
Angel, Lianna
17ce35f5-71ad-434f-b990-487e58bb6832
Cannings-John, Rebecca
f45c9562-b1d0-4c6d-9c7c-8f27cd3e47cd
Jones, Hywel
08149e0a-2674-423f-ba25-d16303fbe3cd
Lau, Mandy
828a2963-4975-4b74-8582-8b7cb3b961c1
Butler, Christopher C
8bf4cace-c34a-4b65-838f-29c2be91e434
Francis, Nick
9b610883-605c-4fee-871d-defaa86ccf8e
Hay, Alastair D
bfae9e44-ae9b-473c-923f-1dea50747023
Heginbothom, Margaret
dc97ef32-7d76-427d-8ab9-83d126306efb
Hood, Kerenza
af7cf839-ca85-4ea9-83c3-3dd31be88b32
Paranjothy, Shantini
04acae3d-1dba-48ee-80e4-6f4b85cb8043
Voort, Judith Van der
d35b2ed1-6e26-4d2e-aa21-62cc637e78e6
Hughes, Kathryn
e176d8ac-a6be-4c93-b7bb-e756362e0c90

Lugg-Widger, Fiona, Angel, Lianna, Cannings-John, Rebecca, Jones, Hywel, Lau, Mandy, Butler, Christopher C, Francis, Nick, Hay, Alastair D, Heginbothom, Margaret, Hood, Kerenza, Paranjothy, Shantini, Voort, Judith Van der and Hughes, Kathryn (2019) Long-term outcomes of urinary tract infection (UTI) in Childhood (LUCI): protocol for an electronic record-linked cohort study. BMJ Open, 9. (doi:10.1136/bmjopen-2018-024210).

Record type: Article

Abstract

Introduction: current guidelines advise the prompt diagnosis and treatment of urinary tract infection (UTI) in children to improve both short and longer term outcomes. However, the risk of long-term complications following childhood UTI is unclear. UTI is relatively common but difficult to diagnose in children as symptoms are non-specific. Diagnosis requires a urine sample, but sampling is difficult and infrequent, and it is not clear if sampling should be given greater priority in primary care. The LUCI study will assess the short, medium and longer term outcomes of childhood UTI associated with routine and systematic sampling practices.

Methods and analysis: two data sets will be established. The first will consist of routinely collected data (hospital, general practice (GP), microbiology) from children born and resident in Wales, linked via the Secure Anonymised Information Linkage (SAIL) Databank (an ?e-cohort?). Urine sampling in this data set reflects normal practice ?routine sampling?. Outcomes (including renal scarring, hypertension, end-stage renal failure, hospital admissions, GP consultations, antibiotic prescriptions) for children with at least one UTI confirmed with microbiological culture (mcUTI) or no mcUTI before the age of 5 will be compared. The second will combine data from two prospective observational studies (?DUTY? and ?EURICA?) employing systematic urine sampling for children presenting to primary care with acute, undifferentiated illness, linked to routine data via SAIL (Wales) and NHS Digital (England). Outcomes (as above, plus features of mcUTI) for children with an mcUTI in this data set, identified through systematic urine sampling, will be compared with those with an mcUTI identified through routine urine sampling (data set 1). Ethics and dissemination: The study protocol has been approved by NHS Wales Research Ethics Committee and the Health Research Authority?s Confidentiality Advisory Group. Methods of innovative study design and findings will be disseminated through peer-review journals and conferences. Results will be of interest to clinical and policy stakeholders in the UK.

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More information

Accepted/In Press date: 8 February 2019
Published date: 1 April 2019

Identifiers

Local EPrints ID: 435559
URI: http://eprints.soton.ac.uk/id/eprint/435559
ISSN: 2044-6055
PURE UUID: f5f8a082-d44c-49f1-b3de-0451aca17c69
ORCID for Nick Francis: ORCID iD orcid.org/0000-0001-8939-7312

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Date deposited: 11 Nov 2019 17:30
Last modified: 17 Mar 2024 03:58

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Contributors

Author: Fiona Lugg-Widger
Author: Lianna Angel
Author: Rebecca Cannings-John
Author: Hywel Jones
Author: Mandy Lau
Author: Christopher C Butler
Author: Nick Francis ORCID iD
Author: Alastair D Hay
Author: Margaret Heginbothom
Author: Kerenza Hood
Author: Shantini Paranjothy
Author: Judith Van der Voort
Author: Kathryn Hughes

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