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Symptomatic GORD in difficult asthma is associated with worse asthma control and related comorbidities: Findings from WATCH

Symptomatic GORD in difficult asthma is associated with worse asthma control and related comorbidities: Findings from WATCH
Symptomatic GORD in difficult asthma is associated with worse asthma control and related comorbidities: Findings from WATCH
Background: Difficult asthma is associated with increased prevalence of gastro-oesophageal reflux disease (GORD). However, it is unclear how controlling comorbid GORD impacts difficult asthma.

Aim: To evaluate the impact of effectively controlling GORD symptoms in difficult asthmatics in the Wessex AsThma Cohort of difficult asthma (WATCH) Southampton UK.

Methods: A retrospective analysis was undertaken to compare the reported symptoms of GORD in 311 adult asthmatics on treatment for GORD. We compared patients with ongoing GORD symptoms against those with no symptoms using Chi square (categorical data) and Mann-Whitney U tests (continuous data).

Results: 208 (67%) difficult asthmatics had GORD, of whom 175 were receiving treatment for GORD. Prevalence of symptomatic GORD in those having treatment did not differ by sex, but was associated with higher BMI, worse asthma control and symptoms of depression, rhinitis and cough.

Conclusion: Inadequately controlled GORD in difficult asthma is associated with increased symptoms of asthma, and related comorbidities. This highlights multiple potential benefits of optimising GORD treatment in difficult asthmatics.
0903-1936
Thirlwall, Yvette
382d3468-33f2-44eb-91af-64fd9b5d8f07
Tariq, Kamran
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Mistry, Heena
216f0018-b071-406c-9b66-0e025ca959a7
Azim, Adnan
87c31e0e-c9bf-4258-9ae9-889e2382e7ba
Barber, Clair
ff31b460-34c3-466c-90e4-f70b3e954c82
Bentley, Kimberley
ea570069-e603-4801-8518-1ddb761cdd3e
Newell, Colin
fd859e4b-b3a6-4722-b1de-2e52c8633899
Haitchi, Hans Michael
10a08979-c9d4-448a-8e4e-35cee89b0c7a
Djukanovic, Ratko
d9a45ee7-6a80-4d84-a0ed-10962660a98d
Kurukulaaratchy, Ramesh
9c7b8105-2892-49f2-8775-54d4961e3e74
Thirlwall, Yvette
382d3468-33f2-44eb-91af-64fd9b5d8f07
Tariq, Kamran
4de9ca91-e58a-49d7-970b-1b1cada17cf7
Mistry, Heena
216f0018-b071-406c-9b66-0e025ca959a7
Azim, Adnan
87c31e0e-c9bf-4258-9ae9-889e2382e7ba
Barber, Clair
ff31b460-34c3-466c-90e4-f70b3e954c82
Bentley, Kimberley
ea570069-e603-4801-8518-1ddb761cdd3e
Newell, Colin
fd859e4b-b3a6-4722-b1de-2e52c8633899
Haitchi, Hans Michael
10a08979-c9d4-448a-8e4e-35cee89b0c7a
Djukanovic, Ratko
d9a45ee7-6a80-4d84-a0ed-10962660a98d
Kurukulaaratchy, Ramesh
9c7b8105-2892-49f2-8775-54d4961e3e74

Thirlwall, Yvette, Tariq, Kamran, Mistry, Heena, Azim, Adnan, Barber, Clair, Bentley, Kimberley, Newell, Colin, Haitchi, Hans Michael, Djukanovic, Ratko and Kurukulaaratchy, Ramesh (2018) Symptomatic GORD in difficult asthma is associated with worse asthma control and related comorbidities: Findings from WATCH. European Respiratory Journal, 52 (Supplement 62). (doi:10.1183/13993003.congress-2018.pa2067).

Record type: Meeting abstract

Abstract

Background: Difficult asthma is associated with increased prevalence of gastro-oesophageal reflux disease (GORD). However, it is unclear how controlling comorbid GORD impacts difficult asthma.

Aim: To evaluate the impact of effectively controlling GORD symptoms in difficult asthmatics in the Wessex AsThma Cohort of difficult asthma (WATCH) Southampton UK.

Methods: A retrospective analysis was undertaken to compare the reported symptoms of GORD in 311 adult asthmatics on treatment for GORD. We compared patients with ongoing GORD symptoms against those with no symptoms using Chi square (categorical data) and Mann-Whitney U tests (continuous data).

Results: 208 (67%) difficult asthmatics had GORD, of whom 175 were receiving treatment for GORD. Prevalence of symptomatic GORD in those having treatment did not differ by sex, but was associated with higher BMI, worse asthma control and symptoms of depression, rhinitis and cough.

Conclusion: Inadequately controlled GORD in difficult asthma is associated with increased symptoms of asthma, and related comorbidities. This highlights multiple potential benefits of optimising GORD treatment in difficult asthmatics.

Full text not available from this repository.

More information

e-pub ahead of print date: 19 November 2018
Venue - Dates: European Respiratory Society Annual congress, Paris, France, 2018-09-15 - 2018-09-19

Identifiers

Local EPrints ID: 435579
URI: http://eprints.soton.ac.uk/id/eprint/435579
ISSN: 0903-1936
PURE UUID: 25fccf98-3fa9-4679-b2f9-6778b9cc44c7
ORCID for Clair Barber: ORCID iD orcid.org/0000-0001-5335-5129
ORCID for Ratko Djukanovic: ORCID iD orcid.org/0000-0001-6039-5612

Catalogue record

Date deposited: 12 Nov 2019 17:30
Last modified: 13 Nov 2019 01:39

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Contributors

Author: Yvette Thirlwall
Author: Kamran Tariq
Author: Heena Mistry
Author: Adnan Azim
Author: Clair Barber ORCID iD
Author: Kimberley Bentley
Author: Colin Newell
Author: Hans Michael Haitchi
Author: Ramesh Kurukulaaratchy

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