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Cell counts in severe asthma; concordance of sputum and BAL in Wessex Severe Asthma Cohort

Cell counts in severe asthma; concordance of sputum and BAL in Wessex Severe Asthma Cohort
Cell counts in severe asthma; concordance of sputum and BAL in Wessex Severe Asthma Cohort
Background: Asthma is widely considered an eosinophilic disease however severe asthma is frequently non-eosinophilic. Treatment options can depend on airway cell counts but proximal and distal airways may not be concordant in terms of cell differential. The Wessex Severe Asthma Cohort (WSAC) recruited 342 participants with severe asthma for detailed phenotyping with some participants undergoing sputum induction and/or bronchoscopy with bronchoalveolar lavage (BAL). We aimed to use data from the WSAC to assess the agreement between sputum and BAL cell differentials. Methods: WSAC participants with severe asthma were included if they underwent both BAL and successful sputum induction. Correlation coefficients and classification tables were used to calculate the agreement between the proximal (sputum) and distal (BAL) compartments. Results: 38 participants were included in the analysis. Correlation coefficients were 0.429 for neutrophil count (p=0.007) and 0.569 for eosinophil count (p
Jones, Thomas
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Brown, Thomas P
cc71b1fd-0d91-4320-a655-3758af716351
Elliott, Scott
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Rupani, Hitasha
ed650f59-d273-46e9-ac34-0cd179f494ca
Chauhan, Anoop J
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Gove, Kerry
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Barber, Clair
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Lau, Laurie
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Howarth, Peter
ff19c8c4-86b0-4a88-8f76-b3d87f142a21
Jones, Thomas
2ed43a38-d65d-4786-9208-a1e1298ce413
Brown, Thomas P
cc71b1fd-0d91-4320-a655-3758af716351
Elliott, Scott
b544b0be-8850-4d22-8f74-97f66809c127
Rupani, Hitasha
ed650f59-d273-46e9-ac34-0cd179f494ca
Chauhan, Anoop J
adbf8f2a-1a9c-499a-b128-02b20818642d
Gove, Kerry
8f043bbb-080d-49b3-9ee5-046f3a636ee0
Barber, Clair
ff31b460-34c3-466c-90e4-f70b3e954c82
Lau, Laurie
2af8045d-6162-4939-aba7-28dd2f60f6a8
Howarth, Peter
ff19c8c4-86b0-4a88-8f76-b3d87f142a21

Jones, Thomas, Brown, Thomas P, Elliott, Scott, Rupani, Hitasha, Chauhan, Anoop J, Gove, Kerry, Barber, Clair, Lau, Laurie and Howarth, Peter (2017) Cell counts in severe asthma; concordance of sputum and BAL in Wessex Severe Asthma Cohort. European Respiratory Society Annual Congress 2017, , Milan, Italy. 09 - 13 Sep 2017.

Record type: Conference or Workshop Item (Paper)

Abstract

Background: Asthma is widely considered an eosinophilic disease however severe asthma is frequently non-eosinophilic. Treatment options can depend on airway cell counts but proximal and distal airways may not be concordant in terms of cell differential. The Wessex Severe Asthma Cohort (WSAC) recruited 342 participants with severe asthma for detailed phenotyping with some participants undergoing sputum induction and/or bronchoscopy with bronchoalveolar lavage (BAL). We aimed to use data from the WSAC to assess the agreement between sputum and BAL cell differentials. Methods: WSAC participants with severe asthma were included if they underwent both BAL and successful sputum induction. Correlation coefficients and classification tables were used to calculate the agreement between the proximal (sputum) and distal (BAL) compartments. Results: 38 participants were included in the analysis. Correlation coefficients were 0.429 for neutrophil count (p=0.007) and 0.569 for eosinophil count (p

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More information

Published date: September 2017
Venue - Dates: European Respiratory Society Annual Congress 2017, , Milan, Italy, 2017-09-09 - 2017-09-13

Identifiers

Local EPrints ID: 435584
URI: http://eprints.soton.ac.uk/id/eprint/435584
PURE UUID: 3c75e66d-e8a9-42a8-9e3f-9eb537166659
ORCID for Clair Barber: ORCID iD orcid.org/0000-0001-5335-5129

Catalogue record

Date deposited: 12 Nov 2019 17:30
Last modified: 10 Nov 2021 03:44

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Contributors

Author: Thomas Jones
Author: Thomas P Brown
Author: Scott Elliott
Author: Hitasha Rupani
Author: Anoop J Chauhan
Author: Kerry Gove
Author: Clair Barber ORCID iD
Author: Laurie Lau
Author: Peter Howarth

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