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Features of adult-onset (19+) difficult asthma differ by sex in the WATCH cohort.

Features of adult-onset (19+) difficult asthma differ by sex in the WATCH cohort.
Features of adult-onset (19+) difficult asthma differ by sex in the WATCH cohort.
Background: Asthma prognosis is thought to be influenced in some part by age of onset and female hormonal status but the mechanisms remain unclear. Aim: To explore differences in clinical presentation between men and women in a population of adult onset difficult asthmatics. Methods: 380 patients aged 17-85 years were recruited into the Wessex AsThma CoHort of difficult asthma (WATCH). Asthma history, questionnaires and biological measurements were taken at enrolment. Those with onset ≥19 were split by sex to explore differences in disease. Results: Age of asthma diagnosis was available in 335 of 380 patients with 48% reporting diagnosis at 19 years or older. Men with adult onset difficult asthma had significantly later age of diagnosis and higher FeNO than women. Their perception of disease severity was less and BMI significantly lower than females. Men had higher IgE, lower propensity to salicylate sensitivity and greater level of airway obstruction though this was not specific to age of onset. Additional sex differences in lung function reported within the total WATCH cohort were not seen in this subset of difficult asthmatics. Significance a=<0.001, b=<0.005 Conclusion: Several features of difficult adult onset asthma differ by sex, suggesting potential sex-specific disease influences. This supports the need for further sex-specific studies that might result in new sex-stratified asthma treatments.
0903-1936
Barber, Clair
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Gove, Kerry
8f043bbb-080d-49b3-9ee5-046f3a636ee0
Knight, Deborah
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Mitchell, Frances
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Haitchi, Hans Michael
10a08979-c9d4-448a-8e4e-35cee89b0c7a
Newell, Colin
fd859e4b-b3a6-4722-b1de-2e52c8633899
Dennison, Paddy
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Wilkinson, Tom M
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Howarth, Peter H
ff19c8c4-86b0-4a88-8f76-b3d87f142a21
Kurukulaaratchy, Ramesh J
9c7b8105-2892-49f2-8775-54d4961e3e74
Barber, Clair
ff31b460-34c3-466c-90e4-f70b3e954c82
Gove, Kerry
8f043bbb-080d-49b3-9ee5-046f3a636ee0
Knight, Deborah
4f44f912-5106-4fb5-9cf2-b4f86440523c
Mitchell, Frances
fb4be2d3-544e-49ce-912e-c5f0f9553a01
Haitchi, Hans Michael
10a08979-c9d4-448a-8e4e-35cee89b0c7a
Newell, Colin
fd859e4b-b3a6-4722-b1de-2e52c8633899
Dennison, Paddy
837dcc21-e806-4c76-92f6-c5b6c0a8e4d9
Wilkinson, Tom M
22f752a3-b84b-49a6-a515-cd8fdf5540ad
Howarth, Peter H
ff19c8c4-86b0-4a88-8f76-b3d87f142a21
Kurukulaaratchy, Ramesh J
9c7b8105-2892-49f2-8775-54d4961e3e74

Barber, Clair, Gove, Kerry, Knight, Deborah, Mitchell, Frances, Haitchi, Hans Michael, Newell, Colin, Dennison, Paddy, Wilkinson, Tom M, Howarth, Peter H and Kurukulaaratchy, Ramesh J (2018) Features of adult-onset (19+) difficult asthma differ by sex in the WATCH cohort. European Respiratory Journal, 52 (Supplement 62). (doi:10.1183/13993003.congress-2018.pa3969).

Record type: Meeting abstract

Abstract

Background: Asthma prognosis is thought to be influenced in some part by age of onset and female hormonal status but the mechanisms remain unclear. Aim: To explore differences in clinical presentation between men and women in a population of adult onset difficult asthmatics. Methods: 380 patients aged 17-85 years were recruited into the Wessex AsThma CoHort of difficult asthma (WATCH). Asthma history, questionnaires and biological measurements were taken at enrolment. Those with onset ≥19 were split by sex to explore differences in disease. Results: Age of asthma diagnosis was available in 335 of 380 patients with 48% reporting diagnosis at 19 years or older. Men with adult onset difficult asthma had significantly later age of diagnosis and higher FeNO than women. Their perception of disease severity was less and BMI significantly lower than females. Men had higher IgE, lower propensity to salicylate sensitivity and greater level of airway obstruction though this was not specific to age of onset. Additional sex differences in lung function reported within the total WATCH cohort were not seen in this subset of difficult asthmatics. Significance a=<0.001, b=<0.005 Conclusion: Several features of difficult adult onset asthma differ by sex, suggesting potential sex-specific disease influences. This supports the need for further sex-specific studies that might result in new sex-stratified asthma treatments.

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e-pub ahead of print date: 19 November 2018
Venue - Dates: European Respiratory Society Annual congress, France, 2018-09-15 - 2018-09-19

Identifiers

Local EPrints ID: 435595
URI: http://eprints.soton.ac.uk/id/eprint/435595
ISSN: 0903-1936
PURE UUID: e2f6adc7-ad10-4b90-ba04-1abd0b6b001b
ORCID for Clair Barber: ORCID iD orcid.org/0000-0001-5335-5129

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Date deposited: 13 Nov 2019 17:30
Last modified: 20 Dec 2019 18:29

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Contributors

Author: Clair Barber ORCID iD
Author: Kerry Gove
Author: Deborah Knight
Author: Frances Mitchell
Author: Hans Michael Haitchi
Author: Colin Newell
Author: Paddy Dennison
Author: Tom M Wilkinson
Author: Peter H Howarth
Author: Ramesh J Kurukulaaratchy

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