Summary of proceedings and expert consensus statements from the international summit "Lipids in Parenteral Nutrition"
Summary of proceedings and expert consensus statements from the international summit "Lipids in Parenteral Nutrition"
Background: The 2018 Lipids in Parenteral Nutrition summit involved a panel of experts in clinical nutrition, lipid metabolism, and pharmacology, to assess the current state of knowledge and develop expert consensus statements regarding the use of intravenous lipid emulsions in various patient populations and clinical settings. The main purpose of the consensus statements is to assist healthcare professionals by providing practical guidance on common clinical questions related to the provision of lipid emulsions as part of parenteral nutrition (PN). Methods: The summit was designed to allow interactive discussion and consensus development. The resulting consensus statements represent the collective opinion of the members of the expert panel, which was informed and supported by scientific evidence and clinical experience. Results: The current article summarizes the key discussion topics from the summit and provides a set of consensus statements designed to complement existing evidence-based guidelines. Lipid emulsions are a major component of PN, serving as a condensed source of energy and essential fatty acids. In addition, lipids modulate a variety of biologic functions, including inflammatory and immune responses, coagulation, and cell signaling. A growing body of evidence suggests that lipid emulsions containing ω-3 fatty acids from fish oil confer important clinical benefits via suppression of inflammatory mediators and activation of pathways involved in the resolution of inflammation. Conclusions: This article provides a set of expert consensus statements to complement formal PN guideline recommendations.
fatty acids, fish oil, immunomodulation, inflammation, lipids, omega-3, parenteral nutrition
S7-S20
Martindale, Robert G.
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Berlana, David
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Boullata, Joseph
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Cai, Wei
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Calder, Philip
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Deshpande, Girish H.
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Evans, David
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Garcia-de-Lorenzo, Abelardo
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Goulet, Olivier
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Li, Ang
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Mayer, Konstantin
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Mundi, Manpreet S.
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Muscaritoli, Maurizio
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Pradelli, Lorenzo
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Rosenthal, Martin
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Seo, Jeong-Meen
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Waitzberg, Dan L.
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Klek, Stanislaw
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12 February 2020
Martindale, Robert G.
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Berlana, David
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Boullata, Joseph
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Cai, Wei
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Calder, Philip
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Deshpande, Girish H.
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Evans, David
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Garcia-de-Lorenzo, Abelardo
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Goulet, Olivier
0af05eb6-3fa7-481b-b62a-844123a1c96e
Li, Ang
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Mayer, Konstantin
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Mundi, Manpreet S.
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Muscaritoli, Maurizio
0036e812-6e7b-47d9-992e-72bdf5520168
Pradelli, Lorenzo
e711632c-2082-4946-82ef-438d020ac1cf
Rosenthal, Martin
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Seo, Jeong-Meen
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Waitzberg, Dan L.
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Klek, Stanislaw
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Martindale, Robert G., Berlana, David, Boullata, Joseph, Cai, Wei, Calder, Philip, Deshpande, Girish H., Evans, David, Garcia-de-Lorenzo, Abelardo, Goulet, Olivier, Li, Ang, Mayer, Konstantin, Mundi, Manpreet S., Muscaritoli, Maurizio, Pradelli, Lorenzo, Rosenthal, Martin, Seo, Jeong-Meen, Waitzberg, Dan L. and Klek, Stanislaw
(2020)
Summary of proceedings and expert consensus statements from the international summit "Lipids in Parenteral Nutrition".
Journal of Parenteral and Enteral Nutrition, 44 (S1), .
(doi:10.1002/jpen.1746).
Abstract
Background: The 2018 Lipids in Parenteral Nutrition summit involved a panel of experts in clinical nutrition, lipid metabolism, and pharmacology, to assess the current state of knowledge and develop expert consensus statements regarding the use of intravenous lipid emulsions in various patient populations and clinical settings. The main purpose of the consensus statements is to assist healthcare professionals by providing practical guidance on common clinical questions related to the provision of lipid emulsions as part of parenteral nutrition (PN). Methods: The summit was designed to allow interactive discussion and consensus development. The resulting consensus statements represent the collective opinion of the members of the expert panel, which was informed and supported by scientific evidence and clinical experience. Results: The current article summarizes the key discussion topics from the summit and provides a set of consensus statements designed to complement existing evidence-based guidelines. Lipid emulsions are a major component of PN, serving as a condensed source of energy and essential fatty acids. In addition, lipids modulate a variety of biologic functions, including inflammatory and immune responses, coagulation, and cell signaling. A growing body of evidence suggests that lipid emulsions containing ω-3 fatty acids from fish oil confer important clinical benefits via suppression of inflammatory mediators and activation of pathways involved in the resolution of inflammation. Conclusions: This article provides a set of expert consensus statements to complement formal PN guideline recommendations.
Text
Main ms peer rev3 RGM comments 24 Sept 2019b
- Accepted Manuscript
More information
Accepted/In Press date: 30 October 2019
e-pub ahead of print date: 12 February 2020
Published date: 12 February 2020
Additional Information:
Funding Information:
The authors are grateful to Fresenius Kabi for organizing the summit upon which the reviews in this supplement are based and for their support in the production of this review. The authors thank KFG Scientific Communications (Austin, Texas, USA) for technical support and Dr Martina Sintzel (mcs medical communication services, Erlenbach, Switzerland) and Dr Richard Clark (freelance medical writer, Dunchurch, Warwickshire, UK) for valuable consultation services.
Publisher Copyright:
© 2020 American Society for Parenteral and Enteral Nutrition
Keywords:
fatty acids, fish oil, immunomodulation, inflammation, lipids, omega-3, parenteral nutrition
Identifiers
Local EPrints ID: 435628
URI: http://eprints.soton.ac.uk/id/eprint/435628
ISSN: 0148-6071
PURE UUID: 490957bb-104c-4211-b5bf-07c485350333
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Date deposited: 14 Nov 2019 17:30
Last modified: 17 Mar 2024 02:42
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Contributors
Author:
Robert G. Martindale
Author:
David Berlana
Author:
Joseph Boullata
Author:
Wei Cai
Author:
Girish H. Deshpande
Author:
David Evans
Author:
Abelardo Garcia-de-Lorenzo
Author:
Olivier Goulet
Author:
Ang Li
Author:
Konstantin Mayer
Author:
Manpreet S. Mundi
Author:
Maurizio Muscaritoli
Author:
Lorenzo Pradelli
Author:
Martin Rosenthal
Author:
Jeong-Meen Seo
Author:
Dan L. Waitzberg
Author:
Stanislaw Klek
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