Deoxyribonucleic acid repair activity is associated with healed coronary plaque rupture by optical coherence tomography

Dan, Kazuhiro, Garcia-Garcia, Hector M., Yacob, Omar, Kuku, Kayode O., Kolm, Paul, Shah, Nikunj, Bennett, Martin R., Curzen, Nick, Waksman, Ron and Mahmoudi, Michael (2019) Deoxyribonucleic acid repair activity is associated with healed coronary plaque rupture by optical coherence tomography. Journal of Cardiovascular Translational Research, 12 (6), 608–610. (doi:10.1007/s12265-019-09904-2).

Abstract

Deoxyribonucleic acid (DNA) damage and repair signaling cascades are related to the development of atherosclerosis. Pathological studies have demonstrated that healed coronary plaque rupture (HCPR) contributes to plaque progression and predisposes to sudden ischemic cardiac death. The objective of this study is to investigate the relationship between HCPR detected by optical coherence tomography (OCT) and DNA ligase. Forty-two patients with both OCT and DNA ligase were prospectively enrolled. The population included patients with stable angina pectoris (SA) and non-ST-elevation myocardial infarction (NSTEMI). It was found that the prevalence of HCPR was greater in subjects with higher DNA ligase activity (correlation coefficient 0.36, p = 0.019). The presence of HCPR in patients with NSTEMI was greater than in patients with SA per OCT analysis; however, there was no statistical difference in this limited population (22.53% versus 12.83%, respectively, p = 0.116). DNA repair activity by DNA ligase was associated with HCPR in advanced coronary artery plaque by OCT.

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Contributors

Author: Nick Curzen

Author: Michael Mahmoudi

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