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Quality of life impact of childhood skin conditions measured using the Children's Dermatology Life Quality Index (CDLQI): a meta-analysis

Quality of life impact of childhood skin conditions measured using the Children's Dermatology Life Quality Index (CDLQI): a meta-analysis
Quality of life impact of childhood skin conditions measured using the Children's Dermatology Life Quality Index (CDLQI): a meta-analysis
Background: the Children's Dermatology Life Quality Index (CDLQI) is the most widely used instrument for measuring the impact of skin disease on quality of life (QoL) in children.

Objectives: to provide a meta-analysis of all published QoL scores for a range of childhood skin conditions.

Methods: studies using the CDLQI questionnaire to measure QoL in skin conditions were identified by searching Medline and Embase from January 1995 (CDLQI creation) to December 2014. Studies were grouped according to condition and baseline scores were combined using meta-analysis.

Results: sixty-seven studies using the CDLQI met the inclusion criteria. The overall estimated CDLQI scores for conditions reported more than once were [point estimate (95% confidence interval, CI), number of studies (n), score range]: atopic eczema [8?5 (7?1?9?8), n = 38, 0?29], acne [5?3 (1?9?8?5), n = 5, 0?30], alopecia [3?1 (0?7?7), n = 2, 0?6], molluscum contagiosum [3?5 (0?6?6?7), n = 5, 0?27], psoriasis [8?0 (3?9?12?1), n = 6, 0?29], scabies [9?2 (0?0?20?3), n = 2, 1?26], urticaria [7?1 (0?15?4), n = 2, 0?22], vitiligo [6?5 (0?7?12?2), n = 2, 0?20] and warts [2?9 (0?5?8), n = 4, 0?16]. Overall, the mean effect on QoL [weighted average CDLQI score 4?6 (95% CI 3?9?5?4)] for children with these conditions was small. However, many children were found to experience a very large impact on QoL (34% of children with atopic eczema, 10% with molluscum contagiosum and 1?5% with acne) in studies where the distributions of scores were provided.

Conclusions: most skin conditions in children have a ?small? mean effect on QoL. However, the range is large and a significant proportion of children with many common skin conditions will experience a very large effect on quality of life.
0007-0963
853-861
Olsen, J. R.
fddbab24-3d5e-4397-a14d-9e7380b3ecdf
Gallacher, J.
387c039a-cbec-4846-8924-03f7af9c8a46
Finlay, Andrew Yule
c07709af-648a-4326-bb5d-22a53806ab77
Piguet, Vincent
1a7fc697-331f-45c8-9fe5-f6a813084869
Francis, Nicholas Andrew
9b610883-605c-4fee-871d-defaa86ccf8e
Olsen, J. R.
fddbab24-3d5e-4397-a14d-9e7380b3ecdf
Gallacher, J.
387c039a-cbec-4846-8924-03f7af9c8a46
Finlay, Andrew Yule
c07709af-648a-4326-bb5d-22a53806ab77
Piguet, Vincent
1a7fc697-331f-45c8-9fe5-f6a813084869
Francis, Nicholas Andrew
9b610883-605c-4fee-871d-defaa86ccf8e

Olsen, J. R., Gallacher, J., Finlay, Andrew Yule, Piguet, Vincent and Francis, Nicholas Andrew (2016) Quality of life impact of childhood skin conditions measured using the Children's Dermatology Life Quality Index (CDLQI): a meta-analysis. British Journal of Dermatology, 174 (4), 853-861. (doi:10.1111/bjd.14361).

Record type: Article

Abstract

Background: the Children's Dermatology Life Quality Index (CDLQI) is the most widely used instrument for measuring the impact of skin disease on quality of life (QoL) in children.

Objectives: to provide a meta-analysis of all published QoL scores for a range of childhood skin conditions.

Methods: studies using the CDLQI questionnaire to measure QoL in skin conditions were identified by searching Medline and Embase from January 1995 (CDLQI creation) to December 2014. Studies were grouped according to condition and baseline scores were combined using meta-analysis.

Results: sixty-seven studies using the CDLQI met the inclusion criteria. The overall estimated CDLQI scores for conditions reported more than once were [point estimate (95% confidence interval, CI), number of studies (n), score range]: atopic eczema [8?5 (7?1?9?8), n = 38, 0?29], acne [5?3 (1?9?8?5), n = 5, 0?30], alopecia [3?1 (0?7?7), n = 2, 0?6], molluscum contagiosum [3?5 (0?6?6?7), n = 5, 0?27], psoriasis [8?0 (3?9?12?1), n = 6, 0?29], scabies [9?2 (0?0?20?3), n = 2, 1?26], urticaria [7?1 (0?15?4), n = 2, 0?22], vitiligo [6?5 (0?7?12?2), n = 2, 0?20] and warts [2?9 (0?5?8), n = 4, 0?16]. Overall, the mean effect on QoL [weighted average CDLQI score 4?6 (95% CI 3?9?5?4)] for children with these conditions was small. However, many children were found to experience a very large impact on QoL (34% of children with atopic eczema, 10% with molluscum contagiosum and 1?5% with acne) in studies where the distributions of scores were provided.

Conclusions: most skin conditions in children have a ?small? mean effect on QoL. However, the range is large and a significant proportion of children with many common skin conditions will experience a very large effect on quality of life.

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More information

e-pub ahead of print date: 21 December 2015
Published date: 1 April 2016

Identifiers

Local EPrints ID: 435736
URI: http://eprints.soton.ac.uk/id/eprint/435736
ISSN: 0007-0963
PURE UUID: 04f0a917-0129-4c68-8efb-29407e5987dc
ORCID for Nicholas Andrew Francis: ORCID iD orcid.org/0000-0001-8939-7312

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Date deposited: 19 Nov 2019 17:30
Last modified: 20 Nov 2019 01:20

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