Infection in arthroplasty: The basic science of bacterial biofilms in its pathogenesis, diagnosis, treatment, and prevention.
Infection in arthroplasty: The basic science of bacterial biofilms in its pathogenesis, diagnosis, treatment, and prevention.
In the past, the diagnosis and treatment of periprosthetic joint infection (PJI) in joint arthroplasty has often been frustrating for orthopaedic surgeons. The application of certain diagnostic criteria and different treatment strategies can be better directed if these infections are placed in the context of microbial biofilms. An understanding of this biofilm mode of microbial infection can help to explain the phenomenon of culture-negative infection as well as provide an understanding of why certain treatment modalities often fail. Continued basic research into the role of biofilms in infection will likely provide improved strategies for the clinical diagnosis and treatment of PJI. This is a review of the current basic science knowledge of biofilm in relation to PJI with an overview of current practices applied in the diagnosis, treatment and prevention of biofilm formation in this setting.
Ibrahim, Mazin S.
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Ryan, Sean
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Seyler, Thorsten
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Arnold, William V.
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Stoodley, Paul
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Haddad, Fares
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Ibrahim, Mazin S.
d9b70758-562a-4ad5-a2c0-27e9e8fab725
Ryan, Sean
4c6e32ab-aa56-4bce-b148-001fa14cfe75
Seyler, Thorsten
7fbca045-90a8-49ee-ad6d-760a4c312efc
Arnold, William V.
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Stoodley, Paul
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Haddad, Fares
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Ibrahim, Mazin S., Ryan, Sean, Seyler, Thorsten, Arnold, William V., Stoodley, Paul and Haddad, Fares
(2019)
Infection in arthroplasty: The basic science of bacterial biofilms in its pathogenesis, diagnosis, treatment, and prevention.
In,
ICL 69: Basic Research.
(ICL 69: Basic Research)
(In Press)
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Book Section
Abstract
In the past, the diagnosis and treatment of periprosthetic joint infection (PJI) in joint arthroplasty has often been frustrating for orthopaedic surgeons. The application of certain diagnostic criteria and different treatment strategies can be better directed if these infections are placed in the context of microbial biofilms. An understanding of this biofilm mode of microbial infection can help to explain the phenomenon of culture-negative infection as well as provide an understanding of why certain treatment modalities often fail. Continued basic research into the role of biofilms in infection will likely provide improved strategies for the clinical diagnosis and treatment of PJI. This is a review of the current basic science knowledge of biofilm in relation to PJI with an overview of current practices applied in the diagnosis, treatment and prevention of biofilm formation in this setting.
Text
Infection in Arthroplasty revised Arnold corrections
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Accepted/In Press date: 25 September 2019
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Local EPrints ID: 435909
URI: http://eprints.soton.ac.uk/id/eprint/435909
PURE UUID: 54d720c1-1ed7-451c-857f-0af20c5b0cc3
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Date deposited: 22 Nov 2019 17:30
Last modified: 17 Mar 2024 03:18
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Contributors
Author:
Mazin S. Ibrahim
Author:
Sean Ryan
Author:
Thorsten Seyler
Author:
William V. Arnold
Author:
Fares Haddad
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