The University of Southampton
University of Southampton Institutional Repository

Coronary bifurcation lesions treated with simple or complex stenting: 5-year survival from patient-level pooled analysis of the Nordic Bifurcation Study and the British Bifurcation Coronary Study

Coronary bifurcation lesions treated with simple or complex stenting: 5-year survival from patient-level pooled analysis of the Nordic Bifurcation Study and the British Bifurcation Coronary Study
Coronary bifurcation lesions treated with simple or complex stenting: 5-year survival from patient-level pooled analysis of the Nordic Bifurcation Study and the British Bifurcation Coronary Study

AIMS: Randomized trials of coronary bifurcation stenting have shown better outcomes from a simple (provisional) strategy rather than a complex (planned two-stent) strategy in terms of short-term efficacy and safety. Here, we report the 5-year all-cause mortality based on pooled patient-level data from two large bifurcation coronary stenting trials with similar methodology: the Nordic Bifurcation Study (NORDIC I) and the British Bifurcation Coronary Study: old, new, and evolving strategies (BBC ONE).

METHODS AND RESULTS: Both multicentre randomized trials compared simple (provisional T-stenting) vs. complex (culotte, crush, and T-stenting) techniques, using drug-eluting stents. We analysed all-cause death at 5 years. Data were collected from phone follow-up, hospital records, and national mortality tracking. Follow-up was complete for 890 out of 913 patients (97%). Both Simple and Complex groups were similar in terms of patient and lesion characteristics. Five-year mortality was lower among patients who underwent a simple strategy rather than a complex strategy [17 patients (3.8%) vs. 31 patients (7.0%); P = 0.04].

CONCLUSION: For coronary bifurcation lesions, a provisional single-stent approach appears to be associated with lower long-term mortality than a systematic dual stenting technique.

Coronary Artery Disease, Humans, Stents, Time Factors, Treatment Outcome
0195-668X
1923-1928
Behan, Miles W
0d167841-2c3a-425f-92fa-cb091a85b22f
Holm, Niels R
ca75dded-fb63-4dbc-90fa-4ae2c29148f3
de Belder, Adam J
3d82ae46-c57b-444d-bf92-6f0381cebf48
Cockburn, James
914e4458-4abd-4ad1-a7ac-62de41f1aef0
Erglis, Andrejs
c9ffea7c-4f87-409a-b968-d28e2f28bbb0
Curzen, Nicholas P
70f3ea49-51b1-418f-8e56-8210aef1abf4
Niemelä, Matti
5c7d3631-6462-405d-9c8f-7716afeb4e52
Oldroyd, Keith G
536fd60e-50d0-4a76-a818-ab6b2b03567f
Kervinen, Kari
ac100985-8a46-49f0-8c5c-a18e893b23df
Kumsars, Indulis
39d90bb2-b456-4f69-861a-83da59bdfc94
Gunnes, Paal
571c5811-37de-4908-82a3-34688394c3cc
Stables, Rodney H
27cf211c-da55-4292-b66d-1963be161e32
Maeng, Michael
2138a010-6b37-4724-a483-e6e394715f60
Ravkilde, Jan
b23b90a9-5263-47d7-9646-e9d38cb1c490
Jensen, Jan Skov
26a03521-524f-4e69-bdc4-79b33da8c962
Christiansen, Evald H
71d64173-ad48-4f7e-a253-a28e4309d8e8
Cooter, Nina
8e6e9e7e-856c-4706-b1a5-bb22ff376ad2
Steigen, Terje K
7b3bbd4c-58ba-4b02-b5b8-d067f8ceb88d
Vikman, Saila
8a9ef842-1108-4d0b-89f2-b6b155786c30
Thuesen, Leif
ff4002b3-072e-41e0-9c02-407930e44188
Lassen, Jens Flensted
49049c2a-0acf-4f36-9a7e-e43217f51121
Hildick-Smith, David
ed5133bd-17d3-48ad-8c2a-cfff6666bc7c
Behan, Miles W
0d167841-2c3a-425f-92fa-cb091a85b22f
Holm, Niels R
ca75dded-fb63-4dbc-90fa-4ae2c29148f3
de Belder, Adam J
3d82ae46-c57b-444d-bf92-6f0381cebf48
Cockburn, James
914e4458-4abd-4ad1-a7ac-62de41f1aef0
Erglis, Andrejs
c9ffea7c-4f87-409a-b968-d28e2f28bbb0
Curzen, Nicholas P
70f3ea49-51b1-418f-8e56-8210aef1abf4
Niemelä, Matti
5c7d3631-6462-405d-9c8f-7716afeb4e52
Oldroyd, Keith G
536fd60e-50d0-4a76-a818-ab6b2b03567f
Kervinen, Kari
ac100985-8a46-49f0-8c5c-a18e893b23df
Kumsars, Indulis
39d90bb2-b456-4f69-861a-83da59bdfc94
Gunnes, Paal
571c5811-37de-4908-82a3-34688394c3cc
Stables, Rodney H
27cf211c-da55-4292-b66d-1963be161e32
Maeng, Michael
2138a010-6b37-4724-a483-e6e394715f60
Ravkilde, Jan
b23b90a9-5263-47d7-9646-e9d38cb1c490
Jensen, Jan Skov
26a03521-524f-4e69-bdc4-79b33da8c962
Christiansen, Evald H
71d64173-ad48-4f7e-a253-a28e4309d8e8
Cooter, Nina
8e6e9e7e-856c-4706-b1a5-bb22ff376ad2
Steigen, Terje K
7b3bbd4c-58ba-4b02-b5b8-d067f8ceb88d
Vikman, Saila
8a9ef842-1108-4d0b-89f2-b6b155786c30
Thuesen, Leif
ff4002b3-072e-41e0-9c02-407930e44188
Lassen, Jens Flensted
49049c2a-0acf-4f36-9a7e-e43217f51121
Hildick-Smith, David
ed5133bd-17d3-48ad-8c2a-cfff6666bc7c

Behan, Miles W, Holm, Niels R, de Belder, Adam J, Cockburn, James, Erglis, Andrejs, Curzen, Nicholas P, Niemelä, Matti, Oldroyd, Keith G, Kervinen, Kari, Kumsars, Indulis, Gunnes, Paal, Stables, Rodney H, Maeng, Michael, Ravkilde, Jan, Jensen, Jan Skov, Christiansen, Evald H, Cooter, Nina, Steigen, Terje K, Vikman, Saila, Thuesen, Leif, Lassen, Jens Flensted and Hildick-Smith, David (2016) Coronary bifurcation lesions treated with simple or complex stenting: 5-year survival from patient-level pooled analysis of the Nordic Bifurcation Study and the British Bifurcation Coronary Study. European Heart Journal, 37 (24), 1923-1928. (doi:10.1093/eurheartj/ehw170).

Record type: Article

Abstract

AIMS: Randomized trials of coronary bifurcation stenting have shown better outcomes from a simple (provisional) strategy rather than a complex (planned two-stent) strategy in terms of short-term efficacy and safety. Here, we report the 5-year all-cause mortality based on pooled patient-level data from two large bifurcation coronary stenting trials with similar methodology: the Nordic Bifurcation Study (NORDIC I) and the British Bifurcation Coronary Study: old, new, and evolving strategies (BBC ONE).

METHODS AND RESULTS: Both multicentre randomized trials compared simple (provisional T-stenting) vs. complex (culotte, crush, and T-stenting) techniques, using drug-eluting stents. We analysed all-cause death at 5 years. Data were collected from phone follow-up, hospital records, and national mortality tracking. Follow-up was complete for 890 out of 913 patients (97%). Both Simple and Complex groups were similar in terms of patient and lesion characteristics. Five-year mortality was lower among patients who underwent a simple strategy rather than a complex strategy [17 patients (3.8%) vs. 31 patients (7.0%); P = 0.04].

CONCLUSION: For coronary bifurcation lesions, a provisional single-stent approach appears to be associated with lower long-term mortality than a systematic dual stenting technique.

Full text not available from this repository.

More information

Accepted/In Press date: 6 April 2016
Published date: 8 May 2016
Additional Information: Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2016. For permissions please email: journals.permissions@oup.com.
Keywords: Coronary Artery Disease, Humans, Stents, Time Factors, Treatment Outcome

Identifiers

Local EPrints ID: 436089
URI: http://eprints.soton.ac.uk/id/eprint/436089
ISSN: 0195-668X
PURE UUID: e17dadd8-826c-42e6-b506-b188ff8bb91d

Catalogue record

Date deposited: 27 Nov 2019 17:30
Last modified: 27 Nov 2019 17:30

Export record

Altmetrics

Contributors

Author: Miles W Behan
Author: Niels R Holm
Author: Adam J de Belder
Author: James Cockburn
Author: Andrejs Erglis
Author: Matti Niemelä
Author: Keith G Oldroyd
Author: Kari Kervinen
Author: Indulis Kumsars
Author: Paal Gunnes
Author: Rodney H Stables
Author: Michael Maeng
Author: Jan Ravkilde
Author: Jan Skov Jensen
Author: Evald H Christiansen
Author: Nina Cooter
Author: Terje K Steigen
Author: Saila Vikman
Author: Leif Thuesen
Author: Jens Flensted Lassen
Author: David Hildick-Smith

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×