Digital tools for more efficient conduct of RCTs: trials unit survey

Nuttall, Jacqueline, Lane, Athene, Blatch-Jones, Amanda, Griffiths, Gareth and Wyatt, Jeremy (2019) Digital tools for more efficient conduct of RCTs: trials unit survey. Trials, 20 (Supplement 1), [P-244]. (doi:10.1186/s13063-019-3688-6).

Abstract

Introduction: Recruitment of participants to, and their retention in, Randomised Controlled Trials (RCTs) is a key determinant of research efficiency, but is challenging. Digital tools and media are increasingly used to reduce costs, waste and delays in the conduct and delivery of research. The aim of this UK Clinical Trials Unit (CTU) survey was to identify which digital recruitment and retention tools are being used to support RCTs, their benefits and success characteristics.

Methods: A survey was sent to all UK Clinical Research Collaboration(UKCRC)-registered CTUs with a webinar to help increase completion. A logic model and definitions of a “digital tool” were developed by iterative refinement by project team members, the Advisory Board(NIHR Research Design service, NHS Trust, NIHR Clinical Research Net-works and patient input) and CTUs.

Results: A total of 24/52 (46%) CTUs responded, 6 (25%) of which stated no prior use. Database screening tools (e.g. CPRD, EMIS) were the tool most widely used (10/22 45%) for recruitment and were con-side red very effective (7/10 70%). The most mentioned success criteria were saving GP time and reaching more patients. Social media was second (6/22 27%), but estimated effectiveness varied consider-ably, with only 17% stating very effective. Fewer retention tools were used, with SMS / email reminders reported most (10/15 67%), but certainty about effectiveness varied. A table of potential digital tools to support recruitment and retention tasks, with examples and a logic model showing relationships between the resources, activities, outputs and outcomes for digital tools were developed.

Discussion: Database screening tools are the most commonly used digital tool for recruitment, with clear success criteria and certainty about effectiveness. Our detailed definition of what constitutes a digital tool, with examples, will inform the NIHR research community about choices and help them identify potential tools to support recruitment and retention.

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Contributors

Author: Amanda Blatch-Jones

Author: Gareth Griffiths

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