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Time to resolution and effect on quality of life of molluscum contagiosum in children in the UK: a prospective community cohort study

Time to resolution and effect on quality of life of molluscum contagiosum in children in the UK: a prospective community cohort study
Time to resolution and effect on quality of life of molluscum contagiosum in children in the UK: a prospective community cohort study

BACKGROUND: Molluscum contagiosum is one of the 50 most prevalent diseases worldwide, but scarce epidemiological data exist for childhood molluscum contagiosum. We aimed to describe the time to resolution, transmission to household child contacts, and effect on quality of life of molluscum contagiosum in children in the UK.

METHODS: Between Jan 1, and Oct 31, 2013, we recruited 306 children with molluscum contagiosum aged between 4 and 15 years in the UK either by referral by general practitioner or self-referral (with diagnosis made by parents by use of the validated Molluscum Contagiosum Diagnostic Tool for Parents [MCDTP]). All participants were asked to complete a questionnaire at recruitment about participant characteristics, transmission, and quality of life. We measured quality of life with the Children's Dermatology Life Quality Index (CDLQI). Participants were prospectively followed up every month to check on their recovery from molluscum contagiosum and transmission to other children in the same household, until the child's lesions were no longer visible.

FINDINGS: The mean time to resolution was 13·3 months (SD 8·2). 80 (30%) of 269 cases had not resolved by 18 months; 36 (13%) had not resolved by 24 months. We recorded transmission to other children in the household in 102 (41%) of 250 cases. Molluscum contagiosum had a small effect on quality of life for most participants, although 33 (11%) of 301 participants had a very severe effect on quality of life (CDLQI score >13). A greater number of lesions was associated with a greater effect on quality of life (H=55·8, p<0·0001).

INTERPRETATION: One in ten children with molluscum contagiosum is likely to have a substantial effect on their quality of life and therefore treatment should be considered for some children, especially those with many lesions or who have been identified as having a severe effect on quality of life. Patients with molluscum contagiosum and their parents need to be given accurate information about the expected natural history of the disorder. Our data provide the most reliable estimates of the expected time to resolution so far and can be used to help set realistic expectations.

FUNDING: Wales School of Primary Care Research (WSPCR) and Cardiff University.

Adolescent, Child, Child, Preschool, Cohort Studies, Disease Transmission, Infectious, Female, Humans, Male, Molluscum Contagiosum/epidemiology, Prospective Studies, Quality of Life/psychology, Surveys and Questionnaires, Time Factors, United Kingdom/epidemiology
1473-3099
190-195
Olsen, Jonathan R.
fe74760c-dd70-4e65-937a-a9c883ab71d6
Gallacher, John
a92ca535-75e3-488a-9890-255212b0328d
Finlay, Andrew Y.
7eb55639-e4ff-44d4-8d10-49595c0e39a2
Piguet, Vincent
1a7fc697-331f-45c8-9fe5-f6a813084869
Francis, Nick A.
9b610883-605c-4fee-871d-defaa86ccf8e
Olsen, Jonathan R.
fe74760c-dd70-4e65-937a-a9c883ab71d6
Gallacher, John
a92ca535-75e3-488a-9890-255212b0328d
Finlay, Andrew Y.
7eb55639-e4ff-44d4-8d10-49595c0e39a2
Piguet, Vincent
1a7fc697-331f-45c8-9fe5-f6a813084869
Francis, Nick A.
9b610883-605c-4fee-871d-defaa86ccf8e

Olsen, Jonathan R., Gallacher, John, Finlay, Andrew Y., Piguet, Vincent and Francis, Nick A. (2015) Time to resolution and effect on quality of life of molluscum contagiosum in children in the UK: a prospective community cohort study. The Lancet Infectious Diseases, 15 (2), 190-195. (doi:10.1016/S1473-3099(14)71053-9).

Record type: Article

Abstract

BACKGROUND: Molluscum contagiosum is one of the 50 most prevalent diseases worldwide, but scarce epidemiological data exist for childhood molluscum contagiosum. We aimed to describe the time to resolution, transmission to household child contacts, and effect on quality of life of molluscum contagiosum in children in the UK.

METHODS: Between Jan 1, and Oct 31, 2013, we recruited 306 children with molluscum contagiosum aged between 4 and 15 years in the UK either by referral by general practitioner or self-referral (with diagnosis made by parents by use of the validated Molluscum Contagiosum Diagnostic Tool for Parents [MCDTP]). All participants were asked to complete a questionnaire at recruitment about participant characteristics, transmission, and quality of life. We measured quality of life with the Children's Dermatology Life Quality Index (CDLQI). Participants were prospectively followed up every month to check on their recovery from molluscum contagiosum and transmission to other children in the same household, until the child's lesions were no longer visible.

FINDINGS: The mean time to resolution was 13·3 months (SD 8·2). 80 (30%) of 269 cases had not resolved by 18 months; 36 (13%) had not resolved by 24 months. We recorded transmission to other children in the household in 102 (41%) of 250 cases. Molluscum contagiosum had a small effect on quality of life for most participants, although 33 (11%) of 301 participants had a very severe effect on quality of life (CDLQI score >13). A greater number of lesions was associated with a greater effect on quality of life (H=55·8, p<0·0001).

INTERPRETATION: One in ten children with molluscum contagiosum is likely to have a substantial effect on their quality of life and therefore treatment should be considered for some children, especially those with many lesions or who have been identified as having a severe effect on quality of life. Patients with molluscum contagiosum and their parents need to be given accurate information about the expected natural history of the disorder. Our data provide the most reliable estimates of the expected time to resolution so far and can be used to help set realistic expectations.

FUNDING: Wales School of Primary Care Research (WSPCR) and Cardiff University.

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More information

e-pub ahead of print date: 23 December 2014
Published date: February 2015
Keywords: Adolescent, Child, Child, Preschool, Cohort Studies, Disease Transmission, Infectious, Female, Humans, Male, Molluscum Contagiosum/epidemiology, Prospective Studies, Quality of Life/psychology, Surveys and Questionnaires, Time Factors, United Kingdom/epidemiology

Identifiers

Local EPrints ID: 436422
URI: http://eprints.soton.ac.uk/id/eprint/436422
ISSN: 1473-3099
PURE UUID: c6b078a7-cbd0-489d-9a33-59d1ef3af238
ORCID for Nick A. Francis: ORCID iD orcid.org/0000-0001-8939-7312

Catalogue record

Date deposited: 10 Dec 2019 17:30
Last modified: 09 Jan 2022 04:08

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Contributors

Author: Jonathan R. Olsen
Author: John Gallacher
Author: Andrew Y. Finlay
Author: Vincent Piguet
Author: Nick A. Francis ORCID iD

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