Transcriptional profile of tuberculosis antigen–specific T cells reveals novel multifunctional features
Transcriptional profile of tuberculosis antigen–specific T cells reveals novel multifunctional features
In latent tuberculosis infection (LTBI) spread of the bacteria is contained by a persistent immune response, which includes CD4+ T cells as important contributors. In this study we show that TB-specific CD4+ T cells have a characteristic chemokine expression signature (CCR6+CXCR3+CCR4−), and that the overall number of these cells is significantly increased in LTBI donors compared with healthy subjects. We have comprehensively characterized the transcriptional signature of CCR6+CXCR3+CCR4− cells and found significant differences to conventional Th1, Th17, and Th2 cells, but no major changes between healthy and LTBI donors. CCR6+CXCR3+CCR4− cells display lineage-specific signatures of both Th1 and Th17 cells, but also have a unique gene expression program, including genes associated with susceptibility to TB, enhanced T cell activation, enhanced cell survival, and induction of a cytotoxic program akin to CTL cells. Overall, the gene expression signature of CCR6+CXCR3+CCR4− cells reveals characteristics important for controlling latent TB infections.
2931-2940
Arlehamn, Cecilia Lindestam
5dac6376-6f50-4e7b-b88b-02b5ec21a7f6
Seumois, Gregory
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Gerasimova, Anna
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Huang, Charlie
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Fu, Zheng
49cfb3db-16a9-43c7-afe0-a66d239942f5
Yue, Xiaojing
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Sette, Alessandro
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Vijayanand, Pandurangan
79514f33-66cf-47cc-a8fa-46bbfc21b7d1
Peters, Bjoern
c49863c8-d2c6-4db4-9d2c-72a7c0cbe117
15 September 2014
Arlehamn, Cecilia Lindestam
5dac6376-6f50-4e7b-b88b-02b5ec21a7f6
Seumois, Gregory
0be7d3d6-5526-458c-aa5c-cce52410a2ed
Gerasimova, Anna
9172f558-68dd-4d71-9e00-ce5314681145
Huang, Charlie
8a8b072e-b4d6-401f-9192-85dba9e4fecc
Fu, Zheng
49cfb3db-16a9-43c7-afe0-a66d239942f5
Yue, Xiaojing
50e8489c-a374-4dfa-bcad-e5c5d5a57c26
Sette, Alessandro
240988b3-3c05-4041-a39b-8be8e145803c
Vijayanand, Pandurangan
79514f33-66cf-47cc-a8fa-46bbfc21b7d1
Peters, Bjoern
c49863c8-d2c6-4db4-9d2c-72a7c0cbe117
Arlehamn, Cecilia Lindestam, Seumois, Gregory, Gerasimova, Anna, Huang, Charlie, Fu, Zheng, Yue, Xiaojing, Sette, Alessandro, Vijayanand, Pandurangan and Peters, Bjoern
(2014)
Transcriptional profile of tuberculosis antigen–specific T cells reveals novel multifunctional features.
The Journal of Immunology, 193 (6), .
(doi:10.4049/jimmunol.1401151).
Abstract
In latent tuberculosis infection (LTBI) spread of the bacteria is contained by a persistent immune response, which includes CD4+ T cells as important contributors. In this study we show that TB-specific CD4+ T cells have a characteristic chemokine expression signature (CCR6+CXCR3+CCR4−), and that the overall number of these cells is significantly increased in LTBI donors compared with healthy subjects. We have comprehensively characterized the transcriptional signature of CCR6+CXCR3+CCR4− cells and found significant differences to conventional Th1, Th17, and Th2 cells, but no major changes between healthy and LTBI donors. CCR6+CXCR3+CCR4− cells display lineage-specific signatures of both Th1 and Th17 cells, but also have a unique gene expression program, including genes associated with susceptibility to TB, enhanced T cell activation, enhanced cell survival, and induction of a cytotoxic program akin to CTL cells. Overall, the gene expression signature of CCR6+CXCR3+CCR4− cells reveals characteristics important for controlling latent TB infections.
Text
nihms-612892
- Accepted Manuscript
More information
Accepted/In Press date: 5 July 2014
e-pub ahead of print date: 4 August 2014
Published date: 15 September 2014
Identifiers
Local EPrints ID: 436480
URI: http://eprints.soton.ac.uk/id/eprint/436480
ISSN: 0022-1767
PURE UUID: 54d8ae92-8fdf-4c1e-9f06-62fc8444b81a
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Date deposited: 11 Dec 2019 17:30
Last modified: 16 Mar 2024 05:37
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Contributors
Author:
Cecilia Lindestam Arlehamn
Author:
Gregory Seumois
Author:
Anna Gerasimova
Author:
Charlie Huang
Author:
Zheng Fu
Author:
Xiaojing Yue
Author:
Alessandro Sette
Author:
Pandurangan Vijayanand
Author:
Bjoern Peters
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