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Data from: Predictors of alcohol responsiveness in dystonia

Data from: Predictors of alcohol responsiveness in dystonia
Data from: Predictors of alcohol responsiveness in dystonia
Objective: To determine predictors of alcohol responsiveness in a large cohort of dystonia patients. Methods: 2159 participants with dystonia were prospectively enrolled in the cross-sectional Dystonia Coalition multicenter study. Patients with secondary, combined or confirmed genetic dystonia (total n=164) or unknown alcohol responsiveness (n= 737) were excluded. Patients answered a standardized questionnaire and were clinically examined using a standardized video protocol and the Burke-Fahn-Marsden Dystonia Rating Scale. Alcohol responsiveness was determined by patients’ self-report. Results: 1258 patients with isolated dystonia (mean age: 59.5±12.2 years, female n=898) met the inclusion criteria; 369 patients (29.3%) reported improvement of dystonia after alcohol consumption. Alcohol responsiveness was not related to sex (p = .742), age (p = .715) or severity of dystonia (p = .623). Age at onset was lower in patients who responded to alcohol (p < .001). Alcohol responsiveness differed across dystonia subgroups (multifocal/generalized > segmental (p = .014); cervical and laryngeal > cranial and limb (p < .001)) and was related to a positive family history of movement disorders (p = .001), and presence of tremor (p < .001). Conclusion: The association of alcohol responsiveness with a positive family history for movement disorders, generalized dystonia, and an earlier age at onset suggests that dystonia patients with an underlying genetic contribution may be more likely to respond beneficially to alcohol. The fact that dystonic tremor may respond to alcohol is in keeping with the observation that the intake of GABAergic drugs may have a beneficial effect in a proportion of patients.
Dystonia, Family history, Alcohol, Tremor
Dryad Digital Repository
Junker, Johanna
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Brandt, Valerie
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Berman, Brian D.
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Vidailhet, Marie
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Roze, Emmanuel
58275f5c-3935-43c1-967e-c8f2a6596241
Weissbach, Anne
a068da20-adf2-48b4-8577-e5e242972a9e
Comella, Cynthia
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Malaty, Irene A.
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Jankovic, Joseph
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LeDoux, Mark S.
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Berardelli, Alfredo
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Barbano, Richard
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Reich, Stephen G.
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Perlmutter, Joel S.
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Jinnah, Hyder A.
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Brüggemann, Norbert
897a113b-3470-4f24-b434-11e838b94ab1
Junker, Johanna
2f29da6e-93c0-4544-bc18-2c320440d6a6
Brandt, Valerie
e41f5832-70e4-407d-8a15-85b861761656
Berman, Brian D.
3366f65a-ca35-409a-904a-7b959d4f3fbb
Vidailhet, Marie
fd25a77f-6650-4e32-a497-25998b3a7e1b
Roze, Emmanuel
58275f5c-3935-43c1-967e-c8f2a6596241
Weissbach, Anne
a068da20-adf2-48b4-8577-e5e242972a9e
Comella, Cynthia
0bc17c32-9a4e-4c0b-9ed0-f7d1bddbb5d4
Malaty, Irene A.
1dbd03a1-fabe-4b91-a364-6edb5f6c5781
Jankovic, Joseph
084ab164-815e-450b-b049-35137c003201
LeDoux, Mark S.
d5591ba6-9360-4a5f-9a28-0613221b2a03
Berardelli, Alfredo
8ec0b805-1642-4758-b6a6-addab0a8527a
Barbano, Richard
1c3c579d-9af5-4b3a-8510-b46c41beed18
Reich, Stephen G.
2a9621f0-8403-486e-9676-467a83f6a124
Perlmutter, Joel S.
39120f4b-118e-453d-9fec-76875b5a3063
Jinnah, Hyder A.
26dd8bb1-9c57-4834-9fe0-d2d3169c00ac
Brüggemann, Norbert
897a113b-3470-4f24-b434-11e838b94ab1

Junker, Johanna, Brandt, Valerie, Berman, Brian D., Vidailhet, Marie, Roze, Emmanuel, Weissbach, Anne, Comella, Cynthia, Malaty, Irene A., Jankovic, Joseph, LeDoux, Mark S., Berardelli, Alfredo, Barbano, Richard, Reich, Stephen G., Perlmutter, Joel S., Jinnah, Hyder A. and Brüggemann, Norbert (2018) Data from: Predictors of alcohol responsiveness in dystonia. Dryad Digital Repository doi:10.5061/DRYAD.HJ08J85 [Dataset]

Record type: Dataset

Abstract

Objective: To determine predictors of alcohol responsiveness in a large cohort of dystonia patients. Methods: 2159 participants with dystonia were prospectively enrolled in the cross-sectional Dystonia Coalition multicenter study. Patients with secondary, combined or confirmed genetic dystonia (total n=164) or unknown alcohol responsiveness (n= 737) were excluded. Patients answered a standardized questionnaire and were clinically examined using a standardized video protocol and the Burke-Fahn-Marsden Dystonia Rating Scale. Alcohol responsiveness was determined by patients’ self-report. Results: 1258 patients with isolated dystonia (mean age: 59.5±12.2 years, female n=898) met the inclusion criteria; 369 patients (29.3%) reported improvement of dystonia after alcohol consumption. Alcohol responsiveness was not related to sex (p = .742), age (p = .715) or severity of dystonia (p = .623). Age at onset was lower in patients who responded to alcohol (p < .001). Alcohol responsiveness differed across dystonia subgroups (multifocal/generalized > segmental (p = .014); cervical and laryngeal > cranial and limb (p < .001)) and was related to a positive family history of movement disorders (p = .001), and presence of tremor (p < .001). Conclusion: The association of alcohol responsiveness with a positive family history for movement disorders, generalized dystonia, and an earlier age at onset suggests that dystonia patients with an underlying genetic contribution may be more likely to respond beneficially to alcohol. The fact that dystonic tremor may respond to alcohol is in keeping with the observation that the intake of GABAergic drugs may have a beneficial effect in a proportion of patients.

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Published date: 2018
Keywords: Dystonia, Family history, Alcohol, Tremor

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Local EPrints ID: 436501
URI: http://eprints.soton.ac.uk/id/eprint/436501
PURE UUID: 7f5c7df5-15c9-48b7-a9a3-da8e681a6911

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Date deposited: 11 Dec 2019 17:31
Last modified: 11 Dec 2019 17:31

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Contributors

Creator: Johanna Junker
Creator: Valerie Brandt
Creator: Brian D. Berman
Creator: Marie Vidailhet
Creator: Emmanuel Roze
Creator: Anne Weissbach
Creator: Cynthia Comella
Creator: Irene A. Malaty
Creator: Joseph Jankovic
Creator: Mark S. LeDoux
Creator: Alfredo Berardelli
Creator: Richard Barbano
Creator: Stephen G. Reich
Creator: Joel S. Perlmutter
Creator: Hyder A. Jinnah
Creator: Norbert Brüggemann

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