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A feasibility study of a psycho‐educational support intervention for men with prostate cancer on active surveillance

A feasibility study of a psycho‐educational support intervention for men with prostate cancer on active surveillance
A feasibility study of a psycho‐educational support intervention for men with prostate cancer on active surveillance
Background
PROACTIVE is a psycho‐educational support intervention for prostate cancer patients managed on Active Surveillance. PROACTIVE is composed of two interdependent components: group workshops and internet‐delivered information modules.

Aims
We conducted a feasibility study to determine the practicality of delivering PROACTIVE at two prostate cancer centres.

Methods and Results
The feasibility study was a mixed‐methods randomized parallel‐group exploratory trial. Participants were randomised using a ratio of 3:1 PROACTIVE group to treatment as usual. Qualitative semi‐structured interviews and quantitative measures were completed at baseline, intervention completion (week 6), and at 6‐month follow‐up. Interview transcripts were analysed thematically using Framework analysis. Descriptive statistics were used to examine recruitment and retention rates and changing trends in outcome measures. Most aspects of the research design and PROACTIVE intervention were acceptable to those participating in the study. In particular, participants valued the opportunity to share and discuss experiences with other prostate cancer patients on Active Surveillance and receive detailed authoritative information. However, three issues were identified: (a) a low response rate (13 participants recruited, response rate 16%), (b) low utilisation of internet delivered information modules, (c) self‐perceived low levels of anxiety amongst participants with the majority perceiving their cancer as not impacting on their day‐to‐day life or causing anxiety.

Conclusions
Due to these significant research design issues, it is not recommended PROACTIVE be evaluated in a large‐scale randomised controlled trial. Further research is required to explore the impact of Active Surveillance on anxiety amongst men with localized prostate cancer managed by Active Surveillance.
2573-8348
1-8
Hughes, John G.
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Leydon, Geraldine M.
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Watts, Sam
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Hughes, Stephanie
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Brindle, Lucy A.
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Arden‐close, Emily
476eebfb-e256-474b-8351-09db1efdeab5
Bacon, Roger
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Birch, Brian
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Carballo, Lallita
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Plant, Hilary
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Moore, Caroline M.
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Stuart, Beth
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Yao, Guiqing
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Lewith, George
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Richardson, Alison
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Hughes, John G.
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Leydon, Geraldine M.
c5cdaff5-0fa1-4d38-b575-b97c2892ec40
Watts, Sam
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Hughes, Stephanie
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Brindle, Lucy A.
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Arden‐close, Emily
476eebfb-e256-474b-8351-09db1efdeab5
Bacon, Roger
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Birch, Brian
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Carballo, Lallita
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Plant, Hilary
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Moore, Caroline M.
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Stuart, Beth
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Yao, Guiqing
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Lewith, George
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Richardson, Alison
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Hughes, John G., Leydon, Geraldine M., Watts, Sam, Hughes, Stephanie, Brindle, Lucy A., Arden‐close, Emily, Bacon, Roger, Birch, Brian, Carballo, Lallita, Plant, Hilary, Moore, Caroline M., Stuart, Beth, Yao, Guiqing, Lewith, George and Richardson, Alison (2019) A feasibility study of a psycho‐educational support intervention for men with prostate cancer on active surveillance. Cancer Reports, 1-8. (doi:10.1002/cnr2.1230).

Record type: Article

Abstract

Background
PROACTIVE is a psycho‐educational support intervention for prostate cancer patients managed on Active Surveillance. PROACTIVE is composed of two interdependent components: group workshops and internet‐delivered information modules.

Aims
We conducted a feasibility study to determine the practicality of delivering PROACTIVE at two prostate cancer centres.

Methods and Results
The feasibility study was a mixed‐methods randomized parallel‐group exploratory trial. Participants were randomised using a ratio of 3:1 PROACTIVE group to treatment as usual. Qualitative semi‐structured interviews and quantitative measures were completed at baseline, intervention completion (week 6), and at 6‐month follow‐up. Interview transcripts were analysed thematically using Framework analysis. Descriptive statistics were used to examine recruitment and retention rates and changing trends in outcome measures. Most aspects of the research design and PROACTIVE intervention were acceptable to those participating in the study. In particular, participants valued the opportunity to share and discuss experiences with other prostate cancer patients on Active Surveillance and receive detailed authoritative information. However, three issues were identified: (a) a low response rate (13 participants recruited, response rate 16%), (b) low utilisation of internet delivered information modules, (c) self‐perceived low levels of anxiety amongst participants with the majority perceiving their cancer as not impacting on their day‐to‐day life or causing anxiety.

Conclusions
Due to these significant research design issues, it is not recommended PROACTIVE be evaluated in a large‐scale randomised controlled trial. Further research is required to explore the impact of Active Surveillance on anxiety amongst men with localized prostate cancer managed by Active Surveillance.

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A feasibility study of a psycho-educational support intervention for men with prostate cancer on active surveillance
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Accepted/In Press date: 11 September 2019
e-pub ahead of print date: 9 December 2019

Identifiers

Local EPrints ID: 436592
URI: http://eprints.soton.ac.uk/id/eprint/436592
ISSN: 2573-8348
PURE UUID: d201b06c-8e81-4e4f-8426-7035cd85f1c8
ORCID for Geraldine M. Leydon: ORCID iD orcid.org/0000-0001-5986-3300
ORCID for Stephanie Hughes: ORCID iD orcid.org/0000-0003-4801-8245
ORCID for Lucy A. Brindle: ORCID iD orcid.org/0000-0002-8933-3754
ORCID for Beth Stuart: ORCID iD orcid.org/0000-0001-5432-7437
ORCID for Alison Richardson: ORCID iD orcid.org/0000-0003-3127-5755

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Date deposited: 17 Dec 2019 17:30
Last modified: 17 Mar 2024 03:28

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Contributors

Author: John G. Hughes
Author: Sam Watts
Author: Lucy A. Brindle ORCID iD
Author: Emily Arden‐close
Author: Roger Bacon
Author: Brian Birch
Author: Lallita Carballo
Author: Hilary Plant
Author: Caroline M. Moore
Author: Beth Stuart ORCID iD
Author: Guiqing Yao
Author: George Lewith

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