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Core outcome set for uncomplicated acute appendicitis in children and young people

Core outcome set for uncomplicated acute appendicitis in children and young people
Core outcome set for uncomplicated acute appendicitis in children and young people
Background

Research studies to inform clinical practice and policy in children and young people with appendicitis are hampered by inconsistent selection and reporting of outcomes. The aim of this study was to develop a core outcome set for reporting all studies of uncomplicated acute appendicitis in children and young people.
Methods

Systematic literature reviews, qualitative interviews with parents and patients treated for uncomplicated acute appendicitis, and a Study‐Specific Advisory Group informed a long list of outcomes. Outcomes were then prioritized by stakeholders based in the UK (patients, parents, and paediatric and general surgeons) in an online three‐round Delphi consensus process, followed by face‐to‐face consensus meetings.
Results

A long list of 40 items was scored by 147 key stakeholders in the first Delphi round, of whom 90 completed the two subsequent Delphi rounds. The final core outcome set comprises 14 outcomes: intra‐abdominal abscess, reoperation (including interventional radiology procedure), readmission to hospital, bowel obstruction, wound infection, antibiotic failure, wound complication, negative appendicectomy, recurrent appendicitis, death, patient stress/psychological distress, length of hospital stay, time away from full activity and child's quality of life.
Conclusion

A core outcome set comprising 14 outcomes across five key domains has been developed for reporting studies in children and young people with uncomplicated acute appendicitis. Further work is required to determine how and when to measure these outcomes.
0007-1323
1013-1022
Sherratt, Frances C.
15d60c07-ff52-4a37-b51e-5de8b39d4624
Allin, Benjamin
38689f5b-299a-45b0-9c61-7619ca524602
Kirkham, Jamie J
3abc8a0c-ac86-424a-ba1c-e7122315245c
Walker, Erin
7f02632a-dc68-40e5-aac6-4bf24a877e83
Young, Bridget
f950d6c8-951a-461a-bf69-5ed67bba2a73
Wood, Wendy
c7e12f30-5332-4717-a0c8-328775e06364
Beasant, Lucy
a080197b-17cd-46eb-8622-b9b85f072268
Eaton, Simon
e14103c2-c06a-45e6-87fe-2358a3371283
Hall, Nigel
6919e8af-3890-42c1-98a7-c110791957cf
the appendicitis core outcome set study group
Sherratt, Frances C.
15d60c07-ff52-4a37-b51e-5de8b39d4624
Allin, Benjamin
38689f5b-299a-45b0-9c61-7619ca524602
Kirkham, Jamie J
3abc8a0c-ac86-424a-ba1c-e7122315245c
Walker, Erin
7f02632a-dc68-40e5-aac6-4bf24a877e83
Young, Bridget
f950d6c8-951a-461a-bf69-5ed67bba2a73
Wood, Wendy
c7e12f30-5332-4717-a0c8-328775e06364
Beasant, Lucy
a080197b-17cd-46eb-8622-b9b85f072268
Eaton, Simon
e14103c2-c06a-45e6-87fe-2358a3371283
Hall, Nigel
6919e8af-3890-42c1-98a7-c110791957cf

Sherratt, Frances C., Allin, Benjamin, Kirkham, Jamie J, Walker, Erin, Young, Bridget, Wood, Wendy, Beasant, Lucy, Eaton, Simon and Hall, Nigel , the appendicitis core outcome set study group (2020) Core outcome set for uncomplicated acute appendicitis in children and young people. British Journal of Surgery, 107 (8), 1013-1022. (doi:10.1002/bjs.11508).

Record type: Article

Abstract

Background

Research studies to inform clinical practice and policy in children and young people with appendicitis are hampered by inconsistent selection and reporting of outcomes. The aim of this study was to develop a core outcome set for reporting all studies of uncomplicated acute appendicitis in children and young people.
Methods

Systematic literature reviews, qualitative interviews with parents and patients treated for uncomplicated acute appendicitis, and a Study‐Specific Advisory Group informed a long list of outcomes. Outcomes were then prioritized by stakeholders based in the UK (patients, parents, and paediatric and general surgeons) in an online three‐round Delphi consensus process, followed by face‐to‐face consensus meetings.
Results

A long list of 40 items was scored by 147 key stakeholders in the first Delphi round, of whom 90 completed the two subsequent Delphi rounds. The final core outcome set comprises 14 outcomes: intra‐abdominal abscess, reoperation (including interventional radiology procedure), readmission to hospital, bowel obstruction, wound infection, antibiotic failure, wound complication, negative appendicectomy, recurrent appendicitis, death, patient stress/psychological distress, length of hospital stay, time away from full activity and child's quality of life.
Conclusion

A core outcome set comprising 14 outcomes across five key domains has been developed for reporting studies in children and young people with uncomplicated acute appendicitis. Further work is required to determine how and when to measure these outcomes.

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Final COS paper - Accepted Manuscript
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More information

Accepted/In Press date: 13 December 2019
e-pub ahead of print date: 17 March 2020
Published date: July 2020
Additional Information: © 2020 The Authors. BJS published by John Wiley & Sons Ltd on behalf of BJS Society Ltd.

Identifiers

Local EPrints ID: 436690
URI: http://eprints.soton.ac.uk/id/eprint/436690
ISSN: 0007-1323
PURE UUID: cbeb1550-63bd-4ce9-89d9-81365095373c
ORCID for Nigel Hall: ORCID iD orcid.org/0000-0001-8570-9374

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Date deposited: 20 Dec 2019 18:31
Last modified: 15 Jun 2022 04:01

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Contributors

Author: Frances C. Sherratt
Author: Benjamin Allin
Author: Jamie J Kirkham
Author: Erin Walker
Author: Bridget Young
Author: Wendy Wood
Author: Lucy Beasant
Author: Simon Eaton
Author: Nigel Hall ORCID iD
Corporate Author: the appendicitis core outcome set study group

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