Thoracic muscle radiation attenuation for the prediction of postoperative pneumonia following partial hepatectomy for colorectal metastasis
Thoracic muscle radiation attenuation for the prediction of postoperative pneumonia following partial hepatectomy for colorectal metastasis
Background
Low skeletal muscle radiation attenuation (SM-RA) is indicative of myosteatosis and diminished muscle function. It is predictive of poor outcome following oncological surgery in several cancer types. Postoperative pneumonia is a known risk factor for increased postoperative mortality. We hypothesized that low SM-RA of the respiratory muscles at the 4th thoracic-vertebra (T4) is associated with postoperative pneumonia following liver surgery.
Methods
Postoperative pneumonia was identified using prospective infection control data. Computed tomography body composition analysis was performed at the L3-and T4 level to determine SM-RA. Body composition variables were corrected for confounders and related to postoperative pneumonia and admission time by multivariable logistic regression.
Results
Body composition analysis of 180 patients was performed. Twenty-one patients developed postoperative pneumonia (11.6%). Multivariable analysis showed that low T4 SM-RA as well as low L3 SM-RA were significantly associated with postoperative pneumonia (OR 3.65, 95% CI 1.41–9.49, p < 0.01) and (OR 3.22, 95% CI 1.20–8.61, p = 0.02, respectively).
Conclusion
Low SM-RA at either the L3-or T4-level is associated with a higher risk of postoperative pneumonia following CLRM resection.
van der Kroft, Gregory
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van Dijk, David P.J.
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Rensen, Sander S.S.
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Van Tiel, Frank H.
59554c46-b599-4108-bfb6-5016ddc229ec
de Greef, Bianca
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West, Malcolm
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Ostridge, Kristoffer
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Dejong, Cornelis H. C.
82dea799-a6e2-46ab-9311-c537581cba18
Neumann, Ulf P.
7ac1d499-f9e5-45ab-bcf0-d0449819b262
Olde Damink, Steven W. M.
504fcca4-2739-494f-a203-70f0d756d3f7
van der Kroft, Gregory
be91999f-0d58-4620-9411-85a0f8bde1e3
van Dijk, David P.J.
6e67c1e2-ca01-454d-bbee-fc0f7ff3f56f
Rensen, Sander S.S.
5d809235-a5ee-48d9-804e-89f711ee7e07
Van Tiel, Frank H.
59554c46-b599-4108-bfb6-5016ddc229ec
de Greef, Bianca
2f256f61-5329-4a3e-81c1-9a7d61365b0c
West, Malcolm
98b67e58-9875-4133-b236-8a10a0a12c04
Ostridge, Kristoffer
d2271bae-b078-4390-8919-8f8c0e20542c
Dejong, Cornelis H. C.
82dea799-a6e2-46ab-9311-c537581cba18
Neumann, Ulf P.
7ac1d499-f9e5-45ab-bcf0-d0449819b262
Olde Damink, Steven W. M.
504fcca4-2739-494f-a203-70f0d756d3f7
van der Kroft, Gregory, van Dijk, David P.J., Rensen, Sander S.S., Van Tiel, Frank H., de Greef, Bianca, West, Malcolm, Ostridge, Kristoffer, Dejong, Cornelis H. C., Neumann, Ulf P. and Olde Damink, Steven W. M.
(2019)
Thoracic muscle radiation attenuation for the prediction of postoperative pneumonia following partial hepatectomy for colorectal metastasis.
HPB.
(doi:10.1016/j.hpb.2019.10.1532).
Abstract
Background
Low skeletal muscle radiation attenuation (SM-RA) is indicative of myosteatosis and diminished muscle function. It is predictive of poor outcome following oncological surgery in several cancer types. Postoperative pneumonia is a known risk factor for increased postoperative mortality. We hypothesized that low SM-RA of the respiratory muscles at the 4th thoracic-vertebra (T4) is associated with postoperative pneumonia following liver surgery.
Methods
Postoperative pneumonia was identified using prospective infection control data. Computed tomography body composition analysis was performed at the L3-and T4 level to determine SM-RA. Body composition variables were corrected for confounders and related to postoperative pneumonia and admission time by multivariable logistic regression.
Results
Body composition analysis of 180 patients was performed. Twenty-one patients developed postoperative pneumonia (11.6%). Multivariable analysis showed that low T4 SM-RA as well as low L3 SM-RA were significantly associated with postoperative pneumonia (OR 3.65, 95% CI 1.41–9.49, p < 0.01) and (OR 3.22, 95% CI 1.20–8.61, p = 0.02, respectively).
Conclusion
Low SM-RA at either the L3-or T4-level is associated with a higher risk of postoperative pneumonia following CLRM resection.
Text
Thoracic Muscle Radiation Attenuation for the Prediction of Postoperative Pneumonia Following Partial Hepatectomy for Colorectal Metastasis_version_5.docx
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More information
Accepted/In Press date: 13 October 2019
e-pub ahead of print date: 15 November 2019
Identifiers
Local EPrints ID: 436829
URI: http://eprints.soton.ac.uk/id/eprint/436829
ISSN: 1365-182X
PURE UUID: 8dc0e558-54e0-4543-8da0-39cccae38122
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Date deposited: 10 Jan 2020 17:34
Last modified: 17 Mar 2024 05:11
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Contributors
Author:
Gregory van der Kroft
Author:
David P.J. van Dijk
Author:
Sander S.S. Rensen
Author:
Frank H. Van Tiel
Author:
Bianca de Greef
Author:
Kristoffer Ostridge
Author:
Cornelis H. C. Dejong
Author:
Ulf P. Neumann
Author:
Steven W. M. Olde Damink
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