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Is radiographic lumbar spondylolisthesis associated with occupational exposures? Findings from a nested case control within the Wakayama spine study

Is radiographic lumbar spondylolisthesis associated with occupational exposures? Findings from a nested case control within the Wakayama spine study
Is radiographic lumbar spondylolisthesis associated with occupational exposures? Findings from a nested case control within the Wakayama spine study
BACKGROUND: To explore the relationship between radiographic spondylolisthesis and occupational factors in a case-control study nested within the Wakayama Spine Study (WSS). METHODS: The WSS is a cross-sectional observational study amongst Japanese adults. All participants completed a lifetime occupational history and underwent X-rays of the lumbar spine (L1-S1) according to a pre-defined protocol. One trained surgeon graded the presence of a spondylolisthesis based upon ≥5% anterior or posterior slip at one or more levels. Cases, with lumbar spondylolisthesis, were compared with controls without, for their principal occupation and occupational exposures. RESULTS: In total, data were available for 722 adults (245 men and 477 women), mean age 70.1 (range 53-93) years. According to the pre-defined radiographic criteria, 117 were defined with spondylolisthesis (cases), leaving 605 controls. Cases were not significantly different from controls for age, gender, BMI, smoking or alcohol intake. However, cases were more than twice as likely to report occupational driving ≥4 h/day (OR 2.39, 95% CI 1.08-5.27) after adjustment for age, gender and BMI. Additionally, after stratification by age using 75 years as a cut-point, cases were more than 3-fold more likely to report having worked in the agricultural/ fishing industries (OR 3.47, 95% CI 1.29-9.29) among those aged < 75 years. A reduced risk of being a case was associated with climbing slopes/steps and walking. CONCLUSIONS: A history of occupational driving and working in the agricultural/fishing industry were associated with radiographic spondylolisthesis in this cross-sectional population study. This finding requires further evaluation in longitudinal studies.
1471-2474
Ishimoto, Yuyu
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Cooper, Cyrus
e05f5612-b493-4273-9b71-9e0ce32bdad6
Ntani, Georgia
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Yamanda, Hiroshi
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Hashizume, Hiroshi
12ff45ac-50ac-4032-98aa-f4ba3907341e
Nagata, Keiji
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Muraki, Shigeyuki
d9b6df18-df2b-4e3c-bc56-2ee1be8fa7b1
Tanaka, Sakae
a19b78ba-91e1-474d-a644-aaff05503a23
Yoshida, Munehito
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Yoshimura, Noriko
a10d916f-afc1-4f89-a7e3-a690e16b4cdd
Walker-Bone, Karen
ad7d1336-ed2c-4f39-ade5-da84eb412109
Ishimoto, Yuyu
8c8108ca-80de-494e-8338-1783396b26eb
Cooper, Cyrus
e05f5612-b493-4273-9b71-9e0ce32bdad6
Ntani, Georgia
9b009e0a-5ab2-4c6e-a9fd-15a601e92be5
Yamanda, Hiroshi
23b64699-52f3-43c9-8702-bef6db780381
Hashizume, Hiroshi
12ff45ac-50ac-4032-98aa-f4ba3907341e
Nagata, Keiji
55a08672-6a7b-4aa4-90e6-26277b832fce
Muraki, Shigeyuki
d9b6df18-df2b-4e3c-bc56-2ee1be8fa7b1
Tanaka, Sakae
a19b78ba-91e1-474d-a644-aaff05503a23
Yoshida, Munehito
64c740a7-2c05-4803-b18b-477a9a383e07
Yoshimura, Noriko
a10d916f-afc1-4f89-a7e3-a690e16b4cdd
Walker-Bone, Karen
ad7d1336-ed2c-4f39-ade5-da84eb412109

Ishimoto, Yuyu, Cooper, Cyrus, Ntani, Georgia, Yamanda, Hiroshi, Hashizume, Hiroshi, Nagata, Keiji, Muraki, Shigeyuki, Tanaka, Sakae, Yoshida, Munehito, Yoshimura, Noriko and Walker-Bone, Karen (2019) Is radiographic lumbar spondylolisthesis associated with occupational exposures? Findings from a nested case control within the Wakayama spine study. BMC Musculoskeletal Disorders, 20, [618]. (doi:10.1186/s12891-019-2994-1).

Record type: Article

Abstract

BACKGROUND: To explore the relationship between radiographic spondylolisthesis and occupational factors in a case-control study nested within the Wakayama Spine Study (WSS). METHODS: The WSS is a cross-sectional observational study amongst Japanese adults. All participants completed a lifetime occupational history and underwent X-rays of the lumbar spine (L1-S1) according to a pre-defined protocol. One trained surgeon graded the presence of a spondylolisthesis based upon ≥5% anterior or posterior slip at one or more levels. Cases, with lumbar spondylolisthesis, were compared with controls without, for their principal occupation and occupational exposures. RESULTS: In total, data were available for 722 adults (245 men and 477 women), mean age 70.1 (range 53-93) years. According to the pre-defined radiographic criteria, 117 were defined with spondylolisthesis (cases), leaving 605 controls. Cases were not significantly different from controls for age, gender, BMI, smoking or alcohol intake. However, cases were more than twice as likely to report occupational driving ≥4 h/day (OR 2.39, 95% CI 1.08-5.27) after adjustment for age, gender and BMI. Additionally, after stratification by age using 75 years as a cut-point, cases were more than 3-fold more likely to report having worked in the agricultural/ fishing industries (OR 3.47, 95% CI 1.29-9.29) among those aged < 75 years. A reduced risk of being a case was associated with climbing slopes/steps and walking. CONCLUSIONS: A history of occupational driving and working in the agricultural/fishing industry were associated with radiographic spondylolisthesis in this cross-sectional population study. This finding requires further evaluation in longitudinal studies.

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Accepted/In Press date: 9 December 2019
e-pub ahead of print date: 26 December 2019
Published date: December 2019

Identifiers

Local EPrints ID: 436837
URI: http://eprints.soton.ac.uk/id/eprint/436837
ISSN: 1471-2474
PURE UUID: 916f4426-f17e-49bf-8fa9-214905e2f26c
ORCID for Cyrus Cooper: ORCID iD orcid.org/0000-0003-3510-0709
ORCID for Karen Walker-Bone: ORCID iD orcid.org/0000-0002-5992-1459

Catalogue record

Date deposited: 10 Jan 2020 17:34
Last modified: 26 Nov 2021 02:43

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Contributors

Author: Yuyu Ishimoto
Author: Cyrus Cooper ORCID iD
Author: Georgia Ntani
Author: Hiroshi Yamanda
Author: Hiroshi Hashizume
Author: Keiji Nagata
Author: Shigeyuki Muraki
Author: Sakae Tanaka
Author: Munehito Yoshida
Author: Noriko Yoshimura

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