Dynamic regulation of GABAA receptor biosynthesis and transport
Dynamic regulation of GABAA receptor biosynthesis and transport
γ-Aminobutyric acid (GABA) receptors are the main receptors supporting inhibition in the central nervous system. These receptors are divided into the ionotropic (GABAA, ion channels) and metabotropic (GABAB, coupled with G proteins) types. Activation of GABAA receptors is the main source of rapid inhibition in the central nervous system. This review addresses dynamic regulation of the delivery of GABAA receptors on formation of inhibitory synapses. The plasticity of inhibitory synapses in regulating the attachment of receptors within them is not discussed. Impairments to the regulation of GABAA receptors has been described in diseases such as epilepsy, anxiety disorders, schizophrenia, and alcoholism. Thus, studies of the biogenesis of GABAA receptors, their dynamic regulation, and their role in the etiology of various diseases are important prerequisites for the development of novel therapeutic strategies.
endoplasmic reticulum, GABA, GABA receptors, Golgi apparatus, regulation of transcription, RNA editing
838-846
Bogdanov, Yu D.
0c970999-e191-4f1b-90d9-7bf25a5d5b4b
15 September 2019
Bogdanov, Yu D.
0c970999-e191-4f1b-90d9-7bf25a5d5b4b
Bogdanov, Yu D.
(2019)
Dynamic regulation of GABAA receptor biosynthesis and transport.
Neuroscience and Behavioral Physiology, 49 (7), .
Abstract
γ-Aminobutyric acid (GABA) receptors are the main receptors supporting inhibition in the central nervous system. These receptors are divided into the ionotropic (GABAA, ion channels) and metabotropic (GABAB, coupled with G proteins) types. Activation of GABAA receptors is the main source of rapid inhibition in the central nervous system. This review addresses dynamic regulation of the delivery of GABAA receptors on formation of inhibitory synapses. The plasticity of inhibitory synapses in regulating the attachment of receptors within them is not discussed. Impairments to the regulation of GABAA receptors has been described in diseases such as epilepsy, anxiety disorders, schizophrenia, and alcoholism. Thus, studies of the biogenesis of GABAA receptors, their dynamic regulation, and their role in the etiology of various diseases are important prerequisites for the development of novel therapeutic strategies.
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Accepted/In Press date: 1 November 2017
e-pub ahead of print date: 13 August 2019
Published date: 15 September 2019
Keywords:
endoplasmic reticulum, GABA, GABA receptors, Golgi apparatus, regulation of transcription, RNA editing
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Local EPrints ID: 436850
URI: http://eprints.soton.ac.uk/id/eprint/436850
ISSN: 0097-0549
PURE UUID: 73a670b9-9500-4a92-8373-bdbcdd4741ab
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Date deposited: 10 Jan 2020 17:35
Last modified: 06 Jun 2024 01:54
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