The University of Southampton
University of Southampton Institutional Repository

Three drug combinations for late-stage Trypanosoma brucei gambiense sleeping sickness: a randomized clinical trial in Uganda

Three drug combinations for late-stage Trypanosoma brucei gambiense sleeping sickness: a randomized clinical trial in Uganda
Three drug combinations for late-stage Trypanosoma brucei gambiense sleeping sickness: a randomized clinical trial in Uganda
Objectives -  Our objective was to compare the efficacy and safety of three drug combinations for the treatment of late-stage human African trypanosomiasis caused by Trypanosoma brucei gambiense. Design - This trial was a randomized, open-label, active control, parallel clinical trial comparing three arms. Setting - The study took place at the Sleeping Sickness Treatment Center run by Médecins Sans Frontières at Omugo, Arua District, Uganda. Participants - Stage 2 patients diagnosed in Northern Uganda were screened for inclusion and a total of 54 selected. Interventions - Three drug combinations were given to randomly assigned patients: melarsoprol-nifurtimox (M+N), melarsoprol-eflornithine (M+E), and nifurtimox-eflornithine (N+E). Dosages were uniform: intravenous (IV) melarsoprol 1.8 mg/kg/d, daily for 10 d; IV eflornithine 400 mg/kg/d, every 6 h for 7 d; oral nifurtimox 15 (adults) or 20 (children
1555-5887
Priotto, Gerardo
d1b595d6-6d71-42ff-bc3d-4dbe35947cb7
Fogg, Carole
42057537-d443-462a-8944-c804252c973b
Balasegaram, Manica
ff1f7cbc-c4ce-4b8d-baf2-7a37fed49f83
Erphas, Olema
d8f8bb24-2c8c-455c-b413-cc65d9dd34a7
Louga, Albino
a7cde104-d84d-4a56-9004-4eb0340df892
Checchi, Francesco
e404c8bf-de19-4af1-b6c1-85c1ebee95e6
Ghabri, Salah
71e2a3d2-b894-4dc6-8051-7c8f597ed228
Piola, Patrice
d5f4e60e-a212-4b81-9d3e-f0f6f3e5f440
Priotto, Gerardo
d1b595d6-6d71-42ff-bc3d-4dbe35947cb7
Fogg, Carole
42057537-d443-462a-8944-c804252c973b
Balasegaram, Manica
ff1f7cbc-c4ce-4b8d-baf2-7a37fed49f83
Erphas, Olema
d8f8bb24-2c8c-455c-b413-cc65d9dd34a7
Louga, Albino
a7cde104-d84d-4a56-9004-4eb0340df892
Checchi, Francesco
e404c8bf-de19-4af1-b6c1-85c1ebee95e6
Ghabri, Salah
71e2a3d2-b894-4dc6-8051-7c8f597ed228
Piola, Patrice
d5f4e60e-a212-4b81-9d3e-f0f6f3e5f440

Priotto, Gerardo, Fogg, Carole, Balasegaram, Manica, Erphas, Olema, Louga, Albino, Checchi, Francesco, Ghabri, Salah and Piola, Patrice (2006) Three drug combinations for late-stage Trypanosoma brucei gambiense sleeping sickness: a randomized clinical trial in Uganda. PLoS Clinical Trials, 1 (8), [e39]. (doi:10.1371/journal.pctr.0010039).

Record type: Article

Abstract

Objectives -  Our objective was to compare the efficacy and safety of three drug combinations for the treatment of late-stage human African trypanosomiasis caused by Trypanosoma brucei gambiense. Design - This trial was a randomized, open-label, active control, parallel clinical trial comparing three arms. Setting - The study took place at the Sleeping Sickness Treatment Center run by Médecins Sans Frontières at Omugo, Arua District, Uganda. Participants - Stage 2 patients diagnosed in Northern Uganda were screened for inclusion and a total of 54 selected. Interventions - Three drug combinations were given to randomly assigned patients: melarsoprol-nifurtimox (M+N), melarsoprol-eflornithine (M+E), and nifurtimox-eflornithine (N+E). Dosages were uniform: intravenous (IV) melarsoprol 1.8 mg/kg/d, daily for 10 d; IV eflornithine 400 mg/kg/d, every 6 h for 7 d; oral nifurtimox 15 (adults) or 20 (children

This record has no associated files available for download.

More information

Accepted/In Press date: 27 October 2006
Published date: 8 December 2006

Identifiers

Local EPrints ID: 436975
URI: http://eprints.soton.ac.uk/id/eprint/436975
ISSN: 1555-5887
PURE UUID: 01863299-07f7-40eb-8682-105914461651
ORCID for Carole Fogg: ORCID iD orcid.org/0000-0002-3000-6185

Catalogue record

Date deposited: 14 Jan 2020 18:34
Last modified: 17 Mar 2024 03:56

Export record

Altmetrics

Contributors

Author: Gerardo Priotto
Author: Carole Fogg ORCID iD
Author: Manica Balasegaram
Author: Olema Erphas
Author: Albino Louga
Author: Francesco Checchi
Author: Salah Ghabri
Author: Patrice Piola

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×