The University of Southampton
University of Southampton Institutional Repository

Perioperative haemodynamic optimisation

Perioperative haemodynamic optimisation
Perioperative haemodynamic optimisation
The use of fluid and inotropic therapies to optimise global haemodynamic variables, in particular oxygen delivery, in critically ill patients has been a controversial area of research for more than 25 years. The aim of this review is to describe the current evidence base for this treatment and how concepts of haemodynamic optimisation have evolved in recent years. The inconsistent findings of a large number of small phase II trials continue to stimulate the debate about the value of this treatment approach. However, important recent developments include the use of optimisation only during periods of resuscitation, more cautious doses of fluid and/or inotropic therapy, confirmation that pulmonary artery catheter use does not result in excess mortality and an improved understanding of the mechanistic effects of haemodynamic optimisation. These advances in our understanding have now informed the design of large randomised trials in various patient groups. The true value of haemodynamic optimisation is likely to be confirmed or refuted within the next 5 years.
Inotrope, Perioperative, Cardiac output, Fluid, Goal-directed, Haemodynamic, Optimisation
457-467
Springer Cham
Edwards, Mark R.
818201d5-7636-4292-9af8-7dd8bcd1fcb5
Pearse, Rupert M.
50f634bc-77c8-4f69-8650-e2b0a29ceaed
Pinsky, Michael R.
Teboul, Jean-Louis
Vincent, Jean-Louis
Edwards, Mark R.
818201d5-7636-4292-9af8-7dd8bcd1fcb5
Pearse, Rupert M.
50f634bc-77c8-4f69-8650-e2b0a29ceaed
Pinsky, Michael R.
Teboul, Jean-Louis
Vincent, Jean-Louis

Edwards, Mark R. and Pearse, Rupert M. (2019) Perioperative haemodynamic optimisation. In, Pinsky, Michael R., Teboul, Jean-Louis and Vincent, Jean-Louis (eds.) Hemodynamic Monitoring. (Lessons from the ICU) Cham. Springer Cham, pp. 457-467. (doi:10.1007/978-3-319-69269-2_36).

Record type: Book Section

Abstract

The use of fluid and inotropic therapies to optimise global haemodynamic variables, in particular oxygen delivery, in critically ill patients has been a controversial area of research for more than 25 years. The aim of this review is to describe the current evidence base for this treatment and how concepts of haemodynamic optimisation have evolved in recent years. The inconsistent findings of a large number of small phase II trials continue to stimulate the debate about the value of this treatment approach. However, important recent developments include the use of optimisation only during periods of resuscitation, more cautious doses of fluid and/or inotropic therapy, confirmation that pulmonary artery catheter use does not result in excess mortality and an improved understanding of the mechanistic effects of haemodynamic optimisation. These advances in our understanding have now informed the design of large randomised trials in various patient groups. The true value of haemodynamic optimisation is likely to be confirmed or refuted within the next 5 years.

This record has no associated files available for download.

More information

e-pub ahead of print date: 22 February 2019
Published date: 2019
Keywords: Inotrope, Perioperative, Cardiac output, Fluid, Goal-directed, Haemodynamic, Optimisation

Identifiers

Local EPrints ID: 436993
URI: http://eprints.soton.ac.uk/id/eprint/436993
PURE UUID: ada24f99-94bd-4b3c-8293-ae0e6e39c51f

Catalogue record

Date deposited: 14 Jan 2020 18:35
Last modified: 16 Mar 2024 05:59

Export record

Altmetrics

Contributors

Author: Mark R. Edwards
Author: Rupert M. Pearse
Editor: Michael R. Pinsky
Editor: Jean-Louis Teboul
Editor: Jean-Louis Vincent

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×