Cardiopulmonary exercise capacity and preoperative markers of inflammation
Cardiopulmonary exercise capacity and preoperative markers of inflammation
Explanatory mechanisms for the association between poor exercise capacity and infections following surgery are underexplored. We hypothesized that aerobic fitness—assessed by cardiopulmonary exercise testing (CPET)—would be associated with circulating inflammatory markers, as quantified by the neutrophil-lymphocyte ratio (NLR) and monocyte subsets. The association between cardiopulmonary reserve and inflammation was tested by multivariable regression analysis with covariates including anaerobic threshold (AT) and malignancy. In a first cohort of 240 colorectal patients, AT was identified as the sole factor associated with higher NLR and absolute and relative lymphopenia . Preoperative leukocyte subsets and monocyte CD14
1-8
Sultan, Pervez
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Edwards, Mark R.
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Gutierrez del Arroyo, Ana
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Cain, David
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Sneyd, J. Robert
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Struthers, Richard
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Minto, Gary
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Ackland, Gareth L.
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26 June 2014
Sultan, Pervez
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Edwards, Mark R.
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Gutierrez del Arroyo, Ana
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Cain, David
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Sneyd, J. Robert
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Struthers, Richard
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Minto, Gary
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Ackland, Gareth L.
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Sultan, Pervez, Edwards, Mark R., Gutierrez del Arroyo, Ana, Cain, David, Sneyd, J. Robert, Struthers, Richard, Minto, Gary and Ackland, Gareth L.
(2014)
Cardiopulmonary exercise capacity and preoperative markers of inflammation.
Mediators of Inflammation, 2014, , [e727451].
(doi:10.1155/2014/727451).
Abstract
Explanatory mechanisms for the association between poor exercise capacity and infections following surgery are underexplored. We hypothesized that aerobic fitness—assessed by cardiopulmonary exercise testing (CPET)—would be associated with circulating inflammatory markers, as quantified by the neutrophil-lymphocyte ratio (NLR) and monocyte subsets. The association between cardiopulmonary reserve and inflammation was tested by multivariable regression analysis with covariates including anaerobic threshold (AT) and malignancy. In a first cohort of 240 colorectal patients, AT was identified as the sole factor associated with higher NLR and absolute and relative lymphopenia . Preoperative leukocyte subsets and monocyte CD14
Text
727451
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Accepted/In Press date: 11 June 2014
Published date: 26 June 2014
Identifiers
Local EPrints ID: 437028
URI: http://eprints.soton.ac.uk/id/eprint/437028
ISSN: 0962-9351
PURE UUID: bcb05046-b5c8-4e7b-82bd-325683568b10
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Date deposited: 15 Jan 2020 17:32
Last modified: 16 Mar 2024 05:59
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Contributors
Author:
Pervez Sultan
Author:
Mark R. Edwards
Author:
Ana Gutierrez del Arroyo
Author:
David Cain
Author:
J. Robert Sneyd
Author:
Richard Struthers
Author:
Gary Minto
Author:
Gareth L. Ackland
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