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Cardiopulmonary exercise capacity and preoperative markers of inflammation

Cardiopulmonary exercise capacity and preoperative markers of inflammation
Cardiopulmonary exercise capacity and preoperative markers of inflammation
Explanatory mechanisms for the association between poor exercise capacity and infections following surgery are underexplored. We hypothesized that aerobic fitness—assessed by cardiopulmonary exercise testing (CPET)—would be associated with circulating inflammatory markers, as quantified by the neutrophil-lymphocyte ratio (NLR) and monocyte subsets. The association between cardiopulmonary reserve and inflammation was tested by multivariable regression analysis with covariates including anaerobic threshold (AT) and malignancy. In a first cohort of 240 colorectal patients, AT was identified as the sole factor associated with higher NLR and absolute and relative lymphopenia . Preoperative leukocyte subsets and monocyte CD14
0962-9351
1-8
Sultan, Pervez
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Edwards, Mark R.
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Gutierrez del Arroyo, Ana
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Cain, David
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Sneyd, J. Robert
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Struthers, Richard
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Minto, Gary
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Ackland, Gareth L.
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Sultan, Pervez
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Edwards, Mark R.
818201d5-7636-4292-9af8-7dd8bcd1fcb5
Gutierrez del Arroyo, Ana
f4a19868-9b13-43ce-bed3-9c87629cd67f
Cain, David
005efd01-1a57-4d7d-99c5-78ae2cb196b1
Sneyd, J. Robert
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Struthers, Richard
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Minto, Gary
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Ackland, Gareth L.
a39cc4b9-a733-405f-bd1a-a86ab57292a0

Sultan, Pervez, Edwards, Mark R., Gutierrez del Arroyo, Ana, Cain, David, Sneyd, J. Robert, Struthers, Richard, Minto, Gary and Ackland, Gareth L. (2014) Cardiopulmonary exercise capacity and preoperative markers of inflammation. Mediators of Inflammation, 2014, 1-8, [e727451]. (doi:10.1155/2014/727451).

Record type: Article

Abstract

Explanatory mechanisms for the association between poor exercise capacity and infections following surgery are underexplored. We hypothesized that aerobic fitness—assessed by cardiopulmonary exercise testing (CPET)—would be associated with circulating inflammatory markers, as quantified by the neutrophil-lymphocyte ratio (NLR) and monocyte subsets. The association between cardiopulmonary reserve and inflammation was tested by multivariable regression analysis with covariates including anaerobic threshold (AT) and malignancy. In a first cohort of 240 colorectal patients, AT was identified as the sole factor associated with higher NLR and absolute and relative lymphopenia . Preoperative leukocyte subsets and monocyte CD14

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Accepted/In Press date: 11 June 2014
Published date: 26 June 2014

Identifiers

Local EPrints ID: 437028
URI: http://eprints.soton.ac.uk/id/eprint/437028
ISSN: 0962-9351
PURE UUID: bcb05046-b5c8-4e7b-82bd-325683568b10

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Date deposited: 15 Jan 2020 17:32
Last modified: 08 Jan 2022 10:41

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Contributors

Author: Pervez Sultan
Author: Mark R. Edwards
Author: Ana Gutierrez del Arroyo
Author: David Cain
Author: J. Robert Sneyd
Author: Richard Struthers
Author: Gary Minto
Author: Gareth L. Ackland

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