The University of Southampton
University of Southampton Institutional Repository

Fluid therapy in critical illness

Fluid therapy in critical illness
Fluid therapy in critical illness
Major surgery and critical illnesses such as sepsis and trauma all disturb normal physiological fluid handling. Intravenous fluid therapy for resuscitation and fluid maintenance is a central part of medical care during these conditions, yet the evidence base supporting practice in this area lacks answers to a number of important questions. Recent research developments include a refinement of our knowledge of the endothelial barrier structure and function and a focus on the potential harm that may be associated with intravenous fluid therapy. Here, we briefly describe the contemporary view of fluid physiology and how this may be disrupted by pathological processes. The important themes in critical illness fluid research are discussed, with a particular focus on two emerging ideas: firstly, that individualising fluid treatment to the patient, their underlying disease state and the phase of that illness may be key to improving clinical outcomes using fluid interventions and, secondly, that fluids should be considered to be drugs, with specific indications and contraindications, dose ranges and potential toxicities.
2046-7648
1-9
Edwards, Mark R
818201d5-7636-4292-9af8-7dd8bcd1fcb5
Mythen, Michael G
940f5be7-e5bc-4a90-94aa-09fdc658caad
Edwards, Mark R
818201d5-7636-4292-9af8-7dd8bcd1fcb5
Mythen, Michael G
940f5be7-e5bc-4a90-94aa-09fdc658caad

Edwards, Mark R and Mythen, Michael G (2014) Fluid therapy in critical illness. Extreme Physiology & Medicine, 3 (16), 1-9, [16]. (doi:10.1186/2046-7648-3-16).

Record type: Article

Abstract

Major surgery and critical illnesses such as sepsis and trauma all disturb normal physiological fluid handling. Intravenous fluid therapy for resuscitation and fluid maintenance is a central part of medical care during these conditions, yet the evidence base supporting practice in this area lacks answers to a number of important questions. Recent research developments include a refinement of our knowledge of the endothelial barrier structure and function and a focus on the potential harm that may be associated with intravenous fluid therapy. Here, we briefly describe the contemporary view of fluid physiology and how this may be disrupted by pathological processes. The important themes in critical illness fluid research are discussed, with a particular focus on two emerging ideas: firstly, that individualising fluid treatment to the patient, their underlying disease state and the phase of that illness may be key to improving clinical outcomes using fluid interventions and, secondly, that fluids should be considered to be drugs, with specific indications and contraindications, dose ranges and potential toxicities.

Text
document-1 - Version of Record
Available under License Creative Commons Attribution.
Download (421kB)

More information

Published date: 29 September 2014

Identifiers

Local EPrints ID: 437029
URI: http://eprints.soton.ac.uk/id/eprint/437029
ISSN: 2046-7648
PURE UUID: a9e2180c-3c43-4b2a-9ef0-32e045d592ac

Catalogue record

Date deposited: 15 Jan 2020 17:32
Last modified: 08 Jan 2022 10:41

Export record

Altmetrics

Contributors

Author: Mark R Edwards
Author: Michael G Mythen

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×