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A randomized controlled trial of pre-procedure simethicone and N-acetylcysteine to improve mucosal visibility during gastroscopy – NICEVIS

A randomized controlled trial of pre-procedure simethicone and N-acetylcysteine to improve mucosal visibility during gastroscopy – NICEVIS
A randomized controlled trial of pre-procedure simethicone and N-acetylcysteine to improve mucosal visibility during gastroscopy – NICEVIS
Background and study aims - Mucosal views can be impaired by residual bubbles and mucus during gastroscopy. This study aimed to determine whether a pre-gastroscopy drink containing simethicone and N-acetylcysteine improves mucosal visualisation.Patients and methods - We conducted a randomized controlled trial recruiting 126 subjects undergoing routine gastroscopy. Subjects were randomized 1:1:1 to receive: A—pre-procedure drink of water, simethicone and N-acetylcysteine (NAC); B—water alone; or C—no preparation. Study endoscopists were blinded to group allocation. Digital images were taken at 4 locations (lower esophagus/upper gastric body/antrum/fundus), and rated for mucosal visibility (MV) using a 4-point scale (1 = best, 4 = worst) by 4 separate experienced endoscopists. The primary outcome measure was mean mucosal visibility score (MVS). Secondary outcome measures were procedure duration and volume of fluid flush required to achieve adequate mucosal views.Results - Mean MVS for Group A was significantly better than for Group B (1.35 vs 2.11, P
2364-3722
E1197-E1202
Basford, Peter
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Brown, James
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Gadeke, Lisa
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Fogg, Carole
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Haysom-Newport, Ben
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Ogollah, Reuben
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Bhattacharyya, Rupam
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Longcroft-wheaton, Gaius
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Thursby-Pelham, Fergus
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Neale, James
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Bhandari, Pradeep
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Basford, Peter
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Brown, James
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Gadeke, Lisa
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Fogg, Carole
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Haysom-Newport, Ben
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Ogollah, Reuben
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Bhattacharyya, Rupam
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Longcroft-wheaton, Gaius
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Thursby-Pelham, Fergus
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Neale, James
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Bhandari, Pradeep
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Basford, Peter, Brown, James, Gadeke, Lisa, Fogg, Carole, Haysom-Newport, Ben, Ogollah, Reuben, Bhattacharyya, Rupam, Longcroft-wheaton, Gaius, Thursby-Pelham, Fergus, Neale, James and Bhandari, Pradeep (2016) A randomized controlled trial of pre-procedure simethicone and N-acetylcysteine to improve mucosal visibility during gastroscopy – NICEVIS. Endoscopy International Open, 4 (11), E1197-E1202. (doi:10.1055/s-0042-117631).

Record type: Article

Abstract

Background and study aims - Mucosal views can be impaired by residual bubbles and mucus during gastroscopy. This study aimed to determine whether a pre-gastroscopy drink containing simethicone and N-acetylcysteine improves mucosal visualisation.Patients and methods - We conducted a randomized controlled trial recruiting 126 subjects undergoing routine gastroscopy. Subjects were randomized 1:1:1 to receive: A—pre-procedure drink of water, simethicone and N-acetylcysteine (NAC); B—water alone; or C—no preparation. Study endoscopists were blinded to group allocation. Digital images were taken at 4 locations (lower esophagus/upper gastric body/antrum/fundus), and rated for mucosal visibility (MV) using a 4-point scale (1 = best, 4 = worst) by 4 separate experienced endoscopists. The primary outcome measure was mean mucosal visibility score (MVS). Secondary outcome measures were procedure duration and volume of fluid flush required to achieve adequate mucosal views.Results - Mean MVS for Group A was significantly better than for Group B (1.35 vs 2.11, P

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Accepted/In Press date: 29 August 2016
e-pub ahead of print date: 28 October 2016
Published date: 1 November 2016

Identifiers

Local EPrints ID: 437039
URI: http://eprints.soton.ac.uk/id/eprint/437039
ISSN: 2364-3722
PURE UUID: 0f96bc01-f54b-4087-9ff6-bbf9ff9e9b2c
ORCID for Carole Fogg: ORCID iD orcid.org/0000-0002-3000-6185

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Date deposited: 15 Jan 2020 17:37
Last modified: 07 Oct 2020 02:24

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