Epigenetics in age related macular degeneration: new discoveries and future perspectives
Epigenetics in age related macular degeneration: new discoveries and future perspectives
The study of Epigenetics has explained some of the ‘missing heritability’ of Age
Related Macular Degeneration (AMD). The epigenome also provides a substantial
contribution to the organisation of the functional retina. There is emerging evidence of
specific epigenetic mechanisms associated with AMD. This ‘AMD epigenome’, may
offer the chance to develop novel AMD treatments.
Age-related macular degeneration, Retina epigenetics
807-818
Gemenetzi, M.
7a1e4e8b-4ca4-47d9-8485-32d382141284
Lotery, A.J.
5ecc2d2d-d0b4-468f-ad2c-df7156f8e514
1 March 2020
Gemenetzi, M.
7a1e4e8b-4ca4-47d9-8485-32d382141284
Lotery, A.J.
5ecc2d2d-d0b4-468f-ad2c-df7156f8e514
Gemenetzi, M. and Lotery, A.J.
(2020)
Epigenetics in age related macular degeneration: new discoveries and future perspectives.
Cellular and Molecular Life Sciences, 77 (5), .
(doi:10.1007/s00018-019-03421-w).
Abstract
The study of Epigenetics has explained some of the ‘missing heritability’ of Age
Related Macular Degeneration (AMD). The epigenome also provides a substantial
contribution to the organisation of the functional retina. There is emerging evidence of
specific epigenetic mechanisms associated with AMD. This ‘AMD epigenome’, may
offer the chance to develop novel AMD treatments.
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Gemenetzi-Lotery2020_Article_EpigeneticsInAge-relatedMacula
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Epigenetics in Age Related Macular degeneration
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Accepted/In Press date: 10 December 2019
e-pub ahead of print date: 2 January 2020
Published date: 1 March 2020
Additional Information:
Funding Information:
We gratefully acknowledge Mr Andy Luff, MD, FRCOphth, Consultant Ophthalmologist and Vitreoretinal Surgeon for his valuable assistance with the language and technical editing of this manuscript as well as for his continued support and inspiration through helpful discussions.
Publisher Copyright:
© 2020, The Author(s).
Keywords:
Age-related macular degeneration, Retina epigenetics
Identifiers
Local EPrints ID: 437151
URI: http://eprints.soton.ac.uk/id/eprint/437151
ISSN: 1420-682X
PURE UUID: f9623e79-02f1-4822-a519-dfa6eb8ccaa8
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Date deposited: 20 Jan 2020 17:30
Last modified: 17 Mar 2024 02:57
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Author:
M. Gemenetzi
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