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Association of adult lung function with accelerated biological aging

Association of adult lung function with accelerated biological aging
Association of adult lung function with accelerated biological aging
Lung function, strongly associated with morbidity and mortality, decreases with age. This study examines whether poor adult lung function is associated with age accelerations (AAs). DNA methylation (DNAm) based AAs, lifespan predictors (GrimAge and plasminogen activator inhibitor 1-PAI1) and their related age-adjusted measures were estimated from peripheral blood at two time points (8-to-11 years apart) in adults from two cohorts: SAPALDIA (n=987) and ECRHS (n=509). Within each cohort and stratified by gender (except for estimators from GrimAge and PAI1), AAs were used as predictors in multivariate linear regression with cross-sectional lung function parameters, and in covariate-adjusted mixed linear regression with longitudinal change in lung function and meta-analysed.

AAs were found cross-sectionally associated with lower mean FEV1 (Forced Expiratory Volume in one second) (AA-residuals:P-value=4x10-4; Intrinsic Epigenetic AA:P-value=2x10-4) in females at the follow-up time point only, and the same trend was observed for FVC (Forced Vital Capacity). Both lifespan and plasma level predictors were observed strongly associated with lung function decline and the decline was stronger in the follow-up time points (strongest association between FEV1 and DNAmAge GrimAge:P-value=1.25x10-17).

This study suggests that DNAm based lifespan and plasma level predictors can be utilised as important factors to assess lung health in adults.
Age acceleration, DNA methylation, Epigenetic clock, Lung function, Respiratory health
1945-4589
518-542
Rezwan, Faisal I.
203f8f38-1f5d-485b-ab11-c546b4276338
Imboden, Medea
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Amaral, Andre F.S.
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Wielscher, Matthias
7ab47d0b-aa3a-43a3-8086-c6b980e56746
Jeong, Ayoung
d742adca-f0fd-4da7-89ba-a01b5e879664
Triebner, Kai
5b48a3c1-e91b-424d-9abc-459d4a25c44c
Real, Francisco Gómez
4d44c9a4-9d5f-4e14-9aa7-fc054ac006a2
Jarvelin, Marjo-Riitta
54bf0cc8-8f32-47db-b22d-6e694f1c1b26
Jarvis, Deborah
65a8e140-6feb-4524-977d-0210045e8e4a
Probst-Hensch, Nicole M.
8884fbd3-d87a-4399-a433-db615089ef68
Holloway, John W.
4bbd77e6-c095-445d-a36b-a50a72f6fe1a
Rezwan, Faisal I.
203f8f38-1f5d-485b-ab11-c546b4276338
Imboden, Medea
7ac4495d-e803-4e18-b6ba-318da568f776
Amaral, Andre F.S.
34906454-eaec-435f-9211-1b42091d5110
Wielscher, Matthias
7ab47d0b-aa3a-43a3-8086-c6b980e56746
Jeong, Ayoung
d742adca-f0fd-4da7-89ba-a01b5e879664
Triebner, Kai
5b48a3c1-e91b-424d-9abc-459d4a25c44c
Real, Francisco Gómez
4d44c9a4-9d5f-4e14-9aa7-fc054ac006a2
Jarvelin, Marjo-Riitta
54bf0cc8-8f32-47db-b22d-6e694f1c1b26
Jarvis, Deborah
65a8e140-6feb-4524-977d-0210045e8e4a
Probst-Hensch, Nicole M.
8884fbd3-d87a-4399-a433-db615089ef68
Holloway, John W.
4bbd77e6-c095-445d-a36b-a50a72f6fe1a

Rezwan, Faisal I., Imboden, Medea, Amaral, Andre F.S., Wielscher, Matthias, Jeong, Ayoung, Triebner, Kai, Real, Francisco Gómez, Jarvelin, Marjo-Riitta, Jarvis, Deborah, Probst-Hensch, Nicole M. and Holloway, John W. (2020) Association of adult lung function with accelerated biological aging. Aging, 12 (1), 518-542. (doi:10.18632/aging.102639).

Record type: Article

Abstract

Lung function, strongly associated with morbidity and mortality, decreases with age. This study examines whether poor adult lung function is associated with age accelerations (AAs). DNA methylation (DNAm) based AAs, lifespan predictors (GrimAge and plasminogen activator inhibitor 1-PAI1) and their related age-adjusted measures were estimated from peripheral blood at two time points (8-to-11 years apart) in adults from two cohorts: SAPALDIA (n=987) and ECRHS (n=509). Within each cohort and stratified by gender (except for estimators from GrimAge and PAI1), AAs were used as predictors in multivariate linear regression with cross-sectional lung function parameters, and in covariate-adjusted mixed linear regression with longitudinal change in lung function and meta-analysed.

AAs were found cross-sectionally associated with lower mean FEV1 (Forced Expiratory Volume in one second) (AA-residuals:P-value=4x10-4; Intrinsic Epigenetic AA:P-value=2x10-4) in females at the follow-up time point only, and the same trend was observed for FVC (Forced Vital Capacity). Both lifespan and plasma level predictors were observed strongly associated with lung function decline and the decline was stronger in the follow-up time points (strongest association between FEV1 and DNAmAge GrimAge:P-value=1.25x10-17).

This study suggests that DNAm based lifespan and plasma level predictors can be utilised as important factors to assess lung health in adults.

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Aging 2020 Vol 12 Advance - Accepted Manuscript
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Association of adult lung function - Version of Record
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More information

Accepted/In Press date: 23 December 2019
e-pub ahead of print date: 11 January 2020
Published date: January 2020
Keywords: Age acceleration, DNA methylation, Epigenetic clock, Lung function, Respiratory health

Identifiers

Local EPrints ID: 437153
URI: http://eprints.soton.ac.uk/id/eprint/437153
ISSN: 1945-4589
PURE UUID: 949755ec-59d5-44fa-98b9-1689bcbd0da6
ORCID for Faisal I. Rezwan: ORCID iD orcid.org/0000-0001-9921-222X
ORCID for John W. Holloway: ORCID iD orcid.org/0000-0001-9998-0464

Catalogue record

Date deposited: 20 Jan 2020 17:31
Last modified: 26 Nov 2021 03:00

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Contributors

Author: Faisal I. Rezwan ORCID iD
Author: Medea Imboden
Author: Andre F.S. Amaral
Author: Matthias Wielscher
Author: Ayoung Jeong
Author: Kai Triebner
Author: Francisco Gómez Real
Author: Marjo-Riitta Jarvelin
Author: Deborah Jarvis
Author: Nicole M. Probst-Hensch

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