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NAFLD as a driver of chronic kidney disease

NAFLD as a driver of chronic kidney disease
NAFLD as a driver of chronic kidney disease

Non-alcoholic fatty liver disease (NAFLD) and chronic kidney disease (CKD) are worldwide public health problems, affecting up to 25–30% (NAFLD), and up to 10–15% (CKD) of the general population. Recently, it has also been established that there is a strong association between NAFLD and CKD, regardless of the presence of potential confounding diseases such as obesity, hypertension and type 2 diabetes. Since NAFLD and CKD are both common diseases that often occur alongside other metabolic conditions, such as type 2 diabetes or metabolic syndrome, elucidating the relative impact of NAFLD on the risk of incident CKD presents a substantial challenge for investigators working in this research field. A growing body of epidemiological evidence suggests that NAFLD is an independent risk factor for CKD and recent evidence also suggests that associated factors such as metabolic syndrome, dysbiosis, unhealthy diets, platelet activation and processes associated with ageing could also contribute mechanisms linking NAFLD and CKD. This narrative review provides an overview of the literature on: a) the evidence for an association and causal link between NAFLD and CKD and b) the underlying mechanisms by which NAFLD (and factors strongly linked with NAFLD) may increase the risk of developing CKD.

Adipose tissue, CKD, Dysbiosis, Gut microbiota, Insulin resistance, Metabolic syndrome, Non-alcoholic fatty liver disease, Type 2 diabetes
0168-8278
785-801
Byrne, Christopher
1370b997-cead-4229-83a7-53301ed2a43c
Targher, Giovanni
043e0811-b389-4922-974e-22e650212c5f
Byrne, Christopher
1370b997-cead-4229-83a7-53301ed2a43c
Targher, Giovanni
043e0811-b389-4922-974e-22e650212c5f

Byrne, Christopher and Targher, Giovanni (2020) NAFLD as a driver of chronic kidney disease. Journal of Hepatology, 72 (4), 785-801. (doi:10.1016/j.jhep.2020.01.013).

Record type: Review

Abstract

Non-alcoholic fatty liver disease (NAFLD) and chronic kidney disease (CKD) are worldwide public health problems, affecting up to 25–30% (NAFLD), and up to 10–15% (CKD) of the general population. Recently, it has also been established that there is a strong association between NAFLD and CKD, regardless of the presence of potential confounding diseases such as obesity, hypertension and type 2 diabetes. Since NAFLD and CKD are both common diseases that often occur alongside other metabolic conditions, such as type 2 diabetes or metabolic syndrome, elucidating the relative impact of NAFLD on the risk of incident CKD presents a substantial challenge for investigators working in this research field. A growing body of epidemiological evidence suggests that NAFLD is an independent risk factor for CKD and recent evidence also suggests that associated factors such as metabolic syndrome, dysbiosis, unhealthy diets, platelet activation and processes associated with ageing could also contribute mechanisms linking NAFLD and CKD. This narrative review provides an overview of the literature on: a) the evidence for an association and causal link between NAFLD and CKD and b) the underlying mechanisms by which NAFLD (and factors strongly linked with NAFLD) may increase the risk of developing CKD.

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More information

Accepted/In Press date: 10 January 2020
e-pub ahead of print date: 12 February 2020
Published date: 1 April 2020
Additional Information: Funding Information: C.D.B. is supported in part by the Southampton NIHR Biomedical Research Centre (IS-BRC-20004), UK. G.T. is supported in part by grants from the University School of Medicine of Verona , Verona, Italy. Publisher Copyright: © 2020 European Association for the Study of the Liver
Keywords: Adipose tissue, CKD, Dysbiosis, Gut microbiota, Insulin resistance, Metabolic syndrome, Non-alcoholic fatty liver disease, Type 2 diabetes

Identifiers

Local EPrints ID: 437182
URI: http://eprints.soton.ac.uk/id/eprint/437182
ISSN: 0168-8278
PURE UUID: b74eb8a2-0186-42ce-bf71-c4bae3cefa63
ORCID for Christopher Byrne: ORCID iD orcid.org/0000-0001-6322-7753

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Date deposited: 21 Jan 2020 17:32
Last modified: 26 Aug 2022 04:01

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Author: Giovanni Targher

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