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The NeST (neoadjuvant systemic therapy in breast cancer) study - Protocol for a prospective multi-centre cohort study to assess the current utilization and short-term outcomes of neoadjuvant systemic therapies in breast cancer

The NeST (neoadjuvant systemic therapy in breast cancer) study - Protocol for a prospective multi-centre cohort study to assess the current utilization and short-term outcomes of neoadjuvant systemic therapies in breast cancer
The NeST (neoadjuvant systemic therapy in breast cancer) study - Protocol for a prospective multi-centre cohort study to assess the current utilization and short-term outcomes of neoadjuvant systemic therapies in breast cancer

Introduction: Neoadjuvant systemic therapy (NST) has several potential advantages in the treatment of breast cancer. However, there is currently considerable variation in NST use across the UK. The NeST study is a national, prospective, multicentre cohort study that will investigate current patterns of care with respect to NST in the UK.

Methods and analysis: Phase 1 - a national practice questionnaire (NPQ) to survey current practice.Phase 2 - a multi-centre prospective cohort study of breast cancer patients, undergoing NST.Women undergoing NST as their MDT recommended primary breast cancer treatment between December 2017 and May 2018 will be included. The breast surgery and oncological professional associations and the trainee research collaborative networks will encourage participation by all breast cancer centres.Patient demographics, radiological, oncological, surgical and pathological data will be collected, including complications and the need for further intervention/treatment. Data will be collated to establish current practice in the UK, regarding NST usage and variability of access and provision of these therapies. Prospective data on 600 patients from ~50 centres are anticipated.Trial registration: ISRCTN11160072.

Ethics and dissemination: Research ethics approval is not required for this study, as per the online Health Research Authority decision tool. The information obtained will provide valuable insights to help patients make informed decisions about their treatment. These data should establish current practice in the UK concerning NST, inform future service delivery as well as identifying further research questions.This protocol will be disseminated through the Mammary Fold Academic Research Collaborative (MFAC), the Reconstructive Surgery Trials Network and the Association of Breast Surgery. Participating units will have access to their own data and collective results will be presented at relevant conferences and published in appropriate peer-reviewed journals, as well as being made accessible to relevant patient groups.

2468-3574
5-11
Irwin, G.W.
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Bannon, F.
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Coles, C.E.
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Copson, E.
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Cutress, R.I.
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Dave, R.V.
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Grayson, M.
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Holcombe, C.
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Irshad, S.
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O'Brien, C.
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O'Connell, R.L.
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Palmieri, C.
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Shaaban, A.M.
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Sharma, N.
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Singh, J.
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Whitehead, I.
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Potter, S.
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McIntosh, S.A.
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Irwin, G.W.
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Bannon, F.
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Coles, C.E.
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Copson, E.
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Cutress, R.I.
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Dave, R.V.
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Grayson, M.
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Holcombe, C.
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Irshad, S.
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O'Brien, C.
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O'Connell, R.L.
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Palmieri, C.
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Shaaban, A.M.
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Sharma, N.
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Singh, J.
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Whitehead, I.
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Potter, S.
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McIntosh, S.A.
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Irwin, G.W., Bannon, F., Coles, C.E., Copson, E., Cutress, R.I., Dave, R.V., Grayson, M., Holcombe, C., Irshad, S., O'Brien, C., O'Connell, R.L., Palmieri, C., Shaaban, A.M., Sharma, N., Singh, J., Whitehead, I., Potter, S. and McIntosh, S.A. (2019) The NeST (neoadjuvant systemic therapy in breast cancer) study - Protocol for a prospective multi-centre cohort study to assess the current utilization and short-term outcomes of neoadjuvant systemic therapies in breast cancer. International Journal of Surgery Protocols, 18, 5-11. (doi:10.1016/j.isjp.2019.10.002).

Record type: Article

Abstract

Introduction: Neoadjuvant systemic therapy (NST) has several potential advantages in the treatment of breast cancer. However, there is currently considerable variation in NST use across the UK. The NeST study is a national, prospective, multicentre cohort study that will investigate current patterns of care with respect to NST in the UK.

Methods and analysis: Phase 1 - a national practice questionnaire (NPQ) to survey current practice.Phase 2 - a multi-centre prospective cohort study of breast cancer patients, undergoing NST.Women undergoing NST as their MDT recommended primary breast cancer treatment between December 2017 and May 2018 will be included. The breast surgery and oncological professional associations and the trainee research collaborative networks will encourage participation by all breast cancer centres.Patient demographics, radiological, oncological, surgical and pathological data will be collected, including complications and the need for further intervention/treatment. Data will be collated to establish current practice in the UK, regarding NST usage and variability of access and provision of these therapies. Prospective data on 600 patients from ~50 centres are anticipated.Trial registration: ISRCTN11160072.

Ethics and dissemination: Research ethics approval is not required for this study, as per the online Health Research Authority decision tool. The information obtained will provide valuable insights to help patients make informed decisions about their treatment. These data should establish current practice in the UK concerning NST, inform future service delivery as well as identifying further research questions.This protocol will be disseminated through the Mammary Fold Academic Research Collaborative (MFAC), the Reconstructive Surgery Trials Network and the Association of Breast Surgery. Participating units will have access to their own data and collective results will be presented at relevant conferences and published in appropriate peer-reviewed journals, as well as being made accessible to relevant patient groups.

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Accepted/In Press date: 19 October 2019
e-pub ahead of print date: 11 November 2019
Published date: 2019

Identifiers

Local EPrints ID: 437298
URI: http://eprints.soton.ac.uk/id/eprint/437298
ISSN: 2468-3574
PURE UUID: f3e6f4e0-d758-4b2d-a734-20eddcc99185

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Date deposited: 24 Jan 2020 17:30
Last modified: 16 Mar 2024 06:09

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Contributors

Author: G.W. Irwin
Author: F. Bannon
Author: C.E. Coles
Author: E. Copson
Author: R.I. Cutress
Author: R.V. Dave
Author: M. Grayson
Author: C. Holcombe
Author: S. Irshad
Author: C. O'Brien
Author: R.L. O'Connell
Author: C. Palmieri
Author: A.M. Shaaban
Author: N. Sharma
Author: J. Singh
Author: I. Whitehead
Author: S. Potter
Author: S.A. McIntosh

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