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Associations with corneal hysteresis in a population cohort: results from 96 010 UK Biobank participants

Associations with corneal hysteresis in a population cohort: results from 96 010 UK Biobank participants
Associations with corneal hysteresis in a population cohort: results from 96 010 UK Biobank participants
Purpose

To describe the distribution of corneal hysteresis (CH) in a large cohort and explore its associated factors and possible clinical applications.

Design

Cross-sectional study within the UK Biobank, a large cohort study in the United Kingdom.

Participants

We analyzed CH data from 93 345 eligible participants in the UK Biobank cohort, aged 40 to 69 years.

Methods

All analyses were performed using left eye data. Linear regression models were used to evaluate associations between CH and demographic, lifestyle, ocular, and systemic variables. Piecewise logistic regression models were used to explore the relationship between self-reported glaucoma and CH.

Main Outcome Measures

Corneal hysteresis (mmHg).

Results

The mean CH was 10.6 mmHg (10.4 mmHg in male and 10.8 mmHg in female participants). After adjusting for covariables, CH was significantly negatively associated with male sex, age, black ethnicity, self-reported glaucoma, diastolic blood pressure, and height. Corneal hysteresis was significantly positively associated with smoking, hyperopia, diabetes, systemic lupus erythematosus (SLE), greater deprivation (Townsend index), and Goldmann-correlated intraocular pressure (IOPg). Self-reported glaucoma and CH were significantly associated when CH was less than 10.1 mmHg (odds ratio, 0.86; 95% confidence interval, 0.79–0.94 per mmHg CH increase) after adjusting for covariables. When CH exceeded 10.1 mmHg, there was no significant association between CH and self-reported glaucoma.

Conclusions

In our analyses, CH was significantly associated with factors including age, sex, and ethnicity, which should be taken into account when interpreting CH values. In our cohort, lower CH was significantly associated with a higher prevalence of self-reported glaucoma when CH was less than 10.1 mmHg. Corneal hysteresis may serve as a biomarker aiding glaucoma case detection.

0161-6420
1500-1510
Zhang, Bing
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UKBiobank Eye and Vision Consortium
Zhang, Bing
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Foster, Paul J.
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Zhang, Bing, Shweikh, Yusrah, Khawaja, Anthony P., Gallacher, John, Bauermeister, Sarah and Foster, Paul J. , UKBiobank Eye and Vision Consortium (2019) Associations with corneal hysteresis in a population cohort: results from 96 010 UK Biobank participants. Ophthalmology, 126 (11), 1500-1510. (doi:10.1016/j.ophtha.2019.06.029).

Record type: Article

Abstract

Purpose

To describe the distribution of corneal hysteresis (CH) in a large cohort and explore its associated factors and possible clinical applications.

Design

Cross-sectional study within the UK Biobank, a large cohort study in the United Kingdom.

Participants

We analyzed CH data from 93 345 eligible participants in the UK Biobank cohort, aged 40 to 69 years.

Methods

All analyses were performed using left eye data. Linear regression models were used to evaluate associations between CH and demographic, lifestyle, ocular, and systemic variables. Piecewise logistic regression models were used to explore the relationship between self-reported glaucoma and CH.

Main Outcome Measures

Corneal hysteresis (mmHg).

Results

The mean CH was 10.6 mmHg (10.4 mmHg in male and 10.8 mmHg in female participants). After adjusting for covariables, CH was significantly negatively associated with male sex, age, black ethnicity, self-reported glaucoma, diastolic blood pressure, and height. Corneal hysteresis was significantly positively associated with smoking, hyperopia, diabetes, systemic lupus erythematosus (SLE), greater deprivation (Townsend index), and Goldmann-correlated intraocular pressure (IOPg). Self-reported glaucoma and CH were significantly associated when CH was less than 10.1 mmHg (odds ratio, 0.86; 95% confidence interval, 0.79–0.94 per mmHg CH increase) after adjusting for covariables. When CH exceeded 10.1 mmHg, there was no significant association between CH and self-reported glaucoma.

Conclusions

In our analyses, CH was significantly associated with factors including age, sex, and ethnicity, which should be taken into account when interpreting CH values. In our cohort, lower CH was significantly associated with a higher prevalence of self-reported glaucoma when CH was less than 10.1 mmHg. Corneal hysteresis may serve as a biomarker aiding glaucoma case detection.

This record has no associated files available for download.

More information

Accepted/In Press date: 28 June 2019
e-pub ahead of print date: 5 July 2019
Published date: 1 November 2019

Identifiers

Local EPrints ID: 437493
URI: http://eprints.soton.ac.uk/id/eprint/437493
ISSN: 0161-6420
PURE UUID: 2c0b47dc-8c4c-4de7-9dc5-e07bb684cd17
ORCID for Roxana O. Carare: ORCID iD orcid.org/0000-0001-6458-3776
ORCID for Sarah Ennis: ORCID iD orcid.org/0000-0003-2648-0869
ORCID for Jane Gibson: ORCID iD orcid.org/0000-0002-0973-8285
ORCID for Andrew J. Lotery: ORCID iD orcid.org/0000-0001-5541-4305
ORCID for Jay Self: ORCID iD orcid.org/0000-0002-1030-9963

Catalogue record

Date deposited: 31 Jan 2020 17:36
Last modified: 10 Jan 2022 02:50

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Contributors

Author: Bing Zhang
Author: Yusrah Shweikh
Author: Anthony P. Khawaja
Author: John Gallacher
Author: Sarah Bauermeister
Author: Paul J. Foster
Author: Tariq Aslam
Author: Sarah A. Barman
Author: Jenny H. Barrett
Author: Paul Bishop
Author: Peter Blows
Author: Catey Bunce
Author: Usha Chakravarthy
Author: Michelle Chan
Author: Sharon Y.L. Chua
Author: David P. Crabb
Author: Philippa M. Cumberland
Author: Alexander Day
Author: Parul Desai
Author: Bal Dhillon
Author: Andrew D. Dick
Author: Cathy Egan
Author: Sarah Ennis ORCID iD
Author: Paul Foster
Author: Marcus Fruttiger
Author: John E.J. Gallacher
Author: David F. Garway-Heath
Author: Jane Gibson ORCID iD
Author: Dan Gore
Author: Jeremy A. Guggenheim
Author: Chris J. Hammond
Author: Alison Hardcastle
Author: Simon P. Harding
Author: Ruth E. Hogg
Author: Pirro Hysi
Author: Pearse A. Keane
Author: Sir Peng T. Khaw
Author: Gerassim dos Lascaratos
Author: Tom Macgillivray
Author: Sarah Mackie
Author: Keith Martin
Author: Michelle McGaughey
Author: Bernadette McGuinness
Author: Gareth J. McKay
Author: Martin McKibbin
Author: Danny Mitry
Author: James E. Morgan
Author: Jay Self ORCID iD
Corporate Author: UKBiobank Eye and Vision Consortium

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