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New targets for therapy: antigen identification in adults with B-cell acute lymphoblastic leukaemia

New targets for therapy: antigen identification in adults with B-cell acute lymphoblastic leukaemia
New targets for therapy: antigen identification in adults with B-cell acute lymphoblastic leukaemia
Acute lymphoblastic leukaemia (ALL) in adults is a rare and difficult-to-treat cancer that is characterised by excess lymphoblasts in the bone marrow. Although many patients achieve remission with chemotherapy, relapse rates are high and the associated impact on survival devastating. Most patients receive chemotherapy and for those whose overall fitness supports it, the most effective treatment to date is allogeneic stem cell transplant that can improve overall survival rates in part due to a ‘graft-versus-leukaemia’ effect. However, due to the rarity of this disease, and the availability of mature B-cell antigens on the cell surface, few new cancer antigens have been identified in adult B-ALL that could act as targets to remove residual disease in first remission or provide alternative targets for escape variants if and when current immunotherapy strategies fail. We have used RT-PCR analysis, literature searches, antibody-specific profiling and gene expression microarray analysis to identify and prioritise antigens as novel targets for the treatment of adult B-ALL.
0340-7004
1-11
Jordaens, Stephanie
23224b90-8e9f-4bd4-898c-0472f0ead044
Cooksey, Leah
5bee0860-bab7-4696-bfc3-7b832af1bae4
Freire Boullosa, Laurie
6d3a0de6-364a-47cd-8d44-d1d561c9b3fb
Van Tendeloo, Viggo
0a652f1c-85f2-4f07-9bc7-d8cd9d3a328c
Smits, Evelien
516028c8-534a-4498-bf94-97a95af08c59
Mills, Ken I.
be9c4b93-fda3-40b1-8514-9191652ab8b7
Orchard, Kim H.
794654ab-d6cc-488a-ac11-c9217433c7a2
Guinn, Barbara-ann
48baa19f-4b9e-4fbd-9fc9-8071e090b854
Jordaens, Stephanie
23224b90-8e9f-4bd4-898c-0472f0ead044
Cooksey, Leah
5bee0860-bab7-4696-bfc3-7b832af1bae4
Freire Boullosa, Laurie
6d3a0de6-364a-47cd-8d44-d1d561c9b3fb
Van Tendeloo, Viggo
0a652f1c-85f2-4f07-9bc7-d8cd9d3a328c
Smits, Evelien
516028c8-534a-4498-bf94-97a95af08c59
Mills, Ken I.
be9c4b93-fda3-40b1-8514-9191652ab8b7
Orchard, Kim H.
794654ab-d6cc-488a-ac11-c9217433c7a2
Guinn, Barbara-ann
48baa19f-4b9e-4fbd-9fc9-8071e090b854

Jordaens, Stephanie, Cooksey, Leah, Freire Boullosa, Laurie, Van Tendeloo, Viggo, Smits, Evelien, Mills, Ken I., Orchard, Kim H. and Guinn, Barbara-ann (2020) New targets for therapy: antigen identification in adults with B-cell acute lymphoblastic leukaemia. Cancer Immunology Immunotherapy, 1-11. (doi:10.1007/s00262-020-02484-0).

Record type: Article

Abstract

Acute lymphoblastic leukaemia (ALL) in adults is a rare and difficult-to-treat cancer that is characterised by excess lymphoblasts in the bone marrow. Although many patients achieve remission with chemotherapy, relapse rates are high and the associated impact on survival devastating. Most patients receive chemotherapy and for those whose overall fitness supports it, the most effective treatment to date is allogeneic stem cell transplant that can improve overall survival rates in part due to a ‘graft-versus-leukaemia’ effect. However, due to the rarity of this disease, and the availability of mature B-cell antigens on the cell surface, few new cancer antigens have been identified in adult B-ALL that could act as targets to remove residual disease in first remission or provide alternative targets for escape variants if and when current immunotherapy strategies fail. We have used RT-PCR analysis, literature searches, antibody-specific profiling and gene expression microarray analysis to identify and prioritise antigens as novel targets for the treatment of adult B-ALL.

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Accepted/In Press date: 4 January 2020
e-pub ahead of print date: 22 January 2020

Identifiers

Local EPrints ID: 437560
URI: http://eprints.soton.ac.uk/id/eprint/437560
ISSN: 0340-7004
PURE UUID: 3316b5cd-f19c-4dcd-b97e-36c4547f00ee
ORCID for Kim H. Orchard: ORCID iD orcid.org/0000-0003-2276-3925

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Date deposited: 05 Feb 2020 17:32
Last modified: 07 Oct 2020 01:47

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Contributors

Author: Stephanie Jordaens
Author: Leah Cooksey
Author: Laurie Freire Boullosa
Author: Viggo Van Tendeloo
Author: Evelien Smits
Author: Ken I. Mills
Author: Kim H. Orchard ORCID iD
Author: Barbara-ann Guinn

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