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Different measures of dietary diversity during infancy and the association with childhood food allergy in a UK birth cohort study

Different measures of dietary diversity during infancy and the association with childhood food allergy in a UK birth cohort study
Different measures of dietary diversity during infancy and the association with childhood food allergy in a UK birth cohort study
Background: Diet Diversity (DD) during infancy may prevent food allergies (FA), possibly by exposing the gastrointestinal microbiota to diverse foods and nutrients.

Objective: to investigate the association between four different measures of DD during infancy and development of FA over the first decade of life.

Methods: a birth cohort born between 2001/2002 were followed prospectively, providing information on socio-demographic, environmental and dietary exposures. Information on age of introduction of a range of foods and food allergens were collected during infancy. Children were assessed for food allergy at 1, 2, 3 and 10 years. DD was defined using four measures in the first year of life: the World Health Organisation (WHO) definition of minimum DD at 6 months, as food diversity (FD) and fruit and vegetable diversity (FVD) at 3, 6 and 9 months, and as food allergen diversity (FAD) at 3, 6, 9, 12 months.

Results: 969 pregnant women were recruited at 12 weeks gestation. 900, 858, 891 and 827 offspring were assessed at 1, 2, 3 and 10 years. Univariate analysis showed that WHO DD (p=0.0047), FD (p=0.0009), FAD (p=0.0048) and FVD (p=0.0174) at 6 months and FD (p=0.0392), FAD (p=0.0233), and FVD (0.0163) at 9 months significantly reduced the odds of FA over the first decade of life. DD measures at 3 months were not associated with FA but only 33% of the cohort had solid foods introduced by this age.

Conclusion: increased infant DD, as measured by four different methods, decreased the likelihood of developing FA.
Diet diversity, Dietary variety, Eczema, Food allergy prevention, Infant feeding
2213-2198
2017-2026
Venter, Carina
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Maslin, Kate
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Holloway, John W.
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Silveira, Lori J.
e7cfa509-cfea-4c2a-84ca-29c9c52c1093
Fleischer, David M.
085e52de-faaa-41a9-8eba-47ff70f8a99d
Dean, Taraneh
c15c05ea-199c-4dc7-96cf-fdccdaafa41d
Arshad, Syed
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Venter, Carina
a9b7dd5e-b0cb-4068-be82-e15b587cc20b
Maslin, Kate
9d337ccf-5720-46b8-8bd1-fecb2f7ac2d1
Holloway, John W.
4bbd77e6-c095-445d-a36b-a50a72f6fe1a
Silveira, Lori J.
e7cfa509-cfea-4c2a-84ca-29c9c52c1093
Fleischer, David M.
085e52de-faaa-41a9-8eba-47ff70f8a99d
Dean, Taraneh
c15c05ea-199c-4dc7-96cf-fdccdaafa41d
Arshad, Syed
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Venter, Carina, Maslin, Kate, Holloway, John W., Silveira, Lori J., Fleischer, David M., Dean, Taraneh and Arshad, Syed (2020) Different measures of dietary diversity during infancy and the association with childhood food allergy in a UK birth cohort study. The Journal of Allergy and Clinical immunology: In Practice, 8 (6), 2017-2026. (doi:10.1016/j.jaip.2020.01.029).

Record type: Article

Abstract

Background: Diet Diversity (DD) during infancy may prevent food allergies (FA), possibly by exposing the gastrointestinal microbiota to diverse foods and nutrients.

Objective: to investigate the association between four different measures of DD during infancy and development of FA over the first decade of life.

Methods: a birth cohort born between 2001/2002 were followed prospectively, providing information on socio-demographic, environmental and dietary exposures. Information on age of introduction of a range of foods and food allergens were collected during infancy. Children were assessed for food allergy at 1, 2, 3 and 10 years. DD was defined using four measures in the first year of life: the World Health Organisation (WHO) definition of minimum DD at 6 months, as food diversity (FD) and fruit and vegetable diversity (FVD) at 3, 6 and 9 months, and as food allergen diversity (FAD) at 3, 6, 9, 12 months.

Results: 969 pregnant women were recruited at 12 weeks gestation. 900, 858, 891 and 827 offspring were assessed at 1, 2, 3 and 10 years. Univariate analysis showed that WHO DD (p=0.0047), FD (p=0.0009), FAD (p=0.0048) and FVD (p=0.0174) at 6 months and FD (p=0.0392), FAD (p=0.0233), and FVD (0.0163) at 9 months significantly reduced the odds of FA over the first decade of life. DD measures at 3 months were not associated with FA but only 33% of the cohort had solid foods introduced by this age.

Conclusion: increased infant DD, as measured by four different methods, decreased the likelihood of developing FA.

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INPRACTICE-D-19-00772_R1 AAM pdf - Accepted Manuscript
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More information

Accepted/In Press date: 14 January 2020
e-pub ahead of print date: 28 January 2020
Keywords: Diet diversity, Dietary variety, Eczema, Food allergy prevention, Infant feeding

Identifiers

Local EPrints ID: 437847
URI: http://eprints.soton.ac.uk/id/eprint/437847
ISSN: 2213-2198
PURE UUID: 125f907c-3a5c-43cf-a0f2-a6c4548226bc
ORCID for John W. Holloway: ORCID iD orcid.org/0000-0001-9998-0464

Catalogue record

Date deposited: 20 Feb 2020 17:30
Last modified: 22 Nov 2021 08:01

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Contributors

Author: Carina Venter
Author: Kate Maslin
Author: Lori J. Silveira
Author: David M. Fleischer
Author: Taraneh Dean
Author: Syed Arshad

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