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Different measures of dietary diversity during infancy and the association with childhood food allergy in a UK birth cohort study

Different measures of dietary diversity during infancy and the association with childhood food allergy in a UK birth cohort study
Different measures of dietary diversity during infancy and the association with childhood food allergy in a UK birth cohort study

Background: Diet diversity (DD) during infancy may prevent food allergies (FA), possibly by exposing the gastrointestinal microbiota to diverse foods and nutrients. Objective: To investigate the association between 4 different measures of DD during infancy and development of FA over the first decade of life. Methods: A birth cohort born between 2001 and 2002 were followed prospectively, providing information on sociodemographic, environmental, and dietary exposures. Information on age of introduction of a range of foods and food allergens was collected during infancy. Children were assessed for FA at 1, 2, 3, and 10 years. DD was defined using 4 measures in the first year of life: the World Health Organization definition of minimum DD at 6 months, as food diversity (FD) and fruit and vegetable diversity (FVD) at 3, 6, and 9 months, and as food allergen diversity (FAD) at 3, 6, 9, and 12 months. Results: A total of 969 pregnant women were recruited at 12-week gestation. A total of 900, 858, 891, and 827 offspring were assessed at 1, 2, 3, and 10 years. Univariate analysis showed that World Health Organization DD (P =.0047), FD (P =.0009), FAD (P =.0048), and FVD (P =.0174) at 6 months and FD (P =.0392), FAD (P =.0233), and FVD (.0163) at 9 months significantly reduced the odds of FA over the first decade of life. DD measures at 3 months were not associated with FA, but only 33% of the cohort had solid foods introduced by this age. Conclusion: Increased infant DD, as measured by 4 different methods, decreased the likelihood of developing FA.

Diet diversity, Dietary variety, Eczema, Food allergy prevention, Infant feeding
2213-2198
2017-2026
Venter, Carina
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Maslin, Kate
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Holloway, John W.
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Silveira, Lori J.
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Fleischer, David M.
085e52de-faaa-41a9-8eba-47ff70f8a99d
Dean, Taraneh
1bb6a824-55c0-484a-a3f9-3f4ea60912fc
Arshad, Syed
917e246d-2e60-472f-8d30-94b01ef28958
Venter, Carina
a9b7dd5e-b0cb-4068-be82-e15b587cc20b
Maslin, Kate
9d337ccf-5720-46b8-8bd1-fecb2f7ac2d1
Holloway, John W.
4bbd77e6-c095-445d-a36b-a50a72f6fe1a
Silveira, Lori J.
e7cfa509-cfea-4c2a-84ca-29c9c52c1093
Fleischer, David M.
085e52de-faaa-41a9-8eba-47ff70f8a99d
Dean, Taraneh
1bb6a824-55c0-484a-a3f9-3f4ea60912fc
Arshad, Syed
917e246d-2e60-472f-8d30-94b01ef28958

Venter, Carina, Maslin, Kate, Holloway, John W., Silveira, Lori J., Fleischer, David M., Dean, Taraneh and Arshad, Syed (2020) Different measures of dietary diversity during infancy and the association with childhood food allergy in a UK birth cohort study. The Journal of Allergy and Clinical immunology: In Practice, 8 (6), 2017-2026. (doi:10.1016/j.jaip.2020.01.029).

Record type: Article

Abstract

Background: Diet diversity (DD) during infancy may prevent food allergies (FA), possibly by exposing the gastrointestinal microbiota to diverse foods and nutrients. Objective: To investigate the association between 4 different measures of DD during infancy and development of FA over the first decade of life. Methods: A birth cohort born between 2001 and 2002 were followed prospectively, providing information on sociodemographic, environmental, and dietary exposures. Information on age of introduction of a range of foods and food allergens was collected during infancy. Children were assessed for FA at 1, 2, 3, and 10 years. DD was defined using 4 measures in the first year of life: the World Health Organization definition of minimum DD at 6 months, as food diversity (FD) and fruit and vegetable diversity (FVD) at 3, 6, and 9 months, and as food allergen diversity (FAD) at 3, 6, 9, and 12 months. Results: A total of 969 pregnant women were recruited at 12-week gestation. A total of 900, 858, 891, and 827 offspring were assessed at 1, 2, 3, and 10 years. Univariate analysis showed that World Health Organization DD (P =.0047), FD (P =.0009), FAD (P =.0048), and FVD (P =.0174) at 6 months and FD (P =.0392), FAD (P =.0233), and FVD (.0163) at 9 months significantly reduced the odds of FA over the first decade of life. DD measures at 3 months were not associated with FA, but only 33% of the cohort had solid foods introduced by this age. Conclusion: Increased infant DD, as measured by 4 different methods, decreased the likelihood of developing FA.

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INPRACTICE-D-19-00772_R1 AAM pdf - Accepted Manuscript
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Accepted/In Press date: 14 January 2020
e-pub ahead of print date: 28 January 2020
Published date: June 2020
Additional Information: Funding Information: The UK Food Standards Agency funded years 1-3 of the FAIR study (ref T0703). The 10-year follow-up was funded by the National Institute for Health Research, UK. The researchers acted independently of the funders. Publisher Copyright: © 2020 American Academy of Allergy, Asthma & Immunology
Keywords: Diet diversity, Dietary variety, Eczema, Food allergy prevention, Infant feeding

Identifiers

Local EPrints ID: 437847
URI: http://eprints.soton.ac.uk/id/eprint/437847
ISSN: 2213-2198
PURE UUID: 125f907c-3a5c-43cf-a0f2-a6c4548226bc
ORCID for John W. Holloway: ORCID iD orcid.org/0000-0001-9998-0464

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Date deposited: 20 Feb 2020 17:30
Last modified: 17 Mar 2024 05:18

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Contributors

Author: Carina Venter
Author: Kate Maslin
Author: Lori J. Silveira
Author: David M. Fleischer
Author: Taraneh Dean
Author: Syed Arshad

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