Joint inference of microsatellite mutation models, population history and genealogies using transdimensional Markov Chain Monte Carlo

Wu, Chieh-Hsi and Drummond, Alexei J (2011) Joint inference of microsatellite mutation models, population history and genealogies using transdimensional Markov Chain Monte Carlo. Genetics, 188 (1), 151-164. (doi:10.1534/genetics.110.125260).

Abstract

We provide a framework for Bayesian coalescent inference from microsatellite data that enables inference of population history parameters averaged over microsatellite mutation models. To achieve this we first implemented a rich family of microsatellite mutation models and related components in the software package BEAST. BEAST is a powerful tool that performs Bayesian MCMC analysis on molecular data to make coalescent and evolutionary inferences. Our implementation permits the application of existing nonparametric methods to microsatellite data. The implemented microsatellite models are based on the replication slippage mechanism and focus on three properties of microsatellite mutation: length dependency of mutation rate, mutational bias toward expansion or contraction, and number of repeat units changed in a single mutation event. We develop a new model that facilitates microsatellite model averaging and Bayesian model selection by transdimensional MCMC. With Bayesian model averaging, the posterior distributions of population history parameters are integrated across a set of microsatellite models and thus account for model uncertainty. Simulated data are used to evaluate our method in terms of accuracy and precision of θ estimation and also identification of the true mutation model. Finally we apply our method to a red colobus monkey data set as an example.

MICROSATELLITES, also called short tandem repeats (STRs), are repetitions of a DNA sequence motif with length between 1 and 6 bp. Because they are abundant, widely distributed in the genome, and highly polymorphic, microsatellites have become one of the most popular genetic markers for making inferences on molecular evolution and population genetics (Shikanoet al. 2010; Sponget al. 2010).

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Contributors

Author: Chieh-Hsi Wu

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