QOS-26 Health-related quality of life (HRQOL) in HIT-SIOP-PNET4 trial survivors: differences between medulloblastoma molecular subgroups

Bull, Kim, Kennedy, Colin, Schwalbe, Ed, Hicks, Debbie, Doz, Francois, Rutkowski, Stefan, Lannering, Birgitta, Pietsch, Torsten and Clifford, Steven (2016) QOS-26 Health-related quality of life (HRQOL) in HIT-SIOP-PNET4 trial survivors: differences between medulloblastoma molecular subgroups. Neuro-Oncology, 18 (suppl 3), iii150-iii151. (doi:10.1093/neuonc/now081.26).

Abstract

OBJECTIVES: Previously we found that SHH subgroup medulloblastomas were associated with better HRQoL among survivors from the SIOP-UKCCSG-PNET3 clinical trial. In the present study, we aimed to repeat this analysis in survivors from HIT-SIOP-PNET4 to further explore the relationship between HRQoL and the underlying biology of medulloblastoma. METHODS: Using data from our previous studies of these trial participants, HIT-SIOP-PNET4 survivors whose tumours had been assigned to disease molecular subgroup (SHH, WNT, Group3, and Group4) using a novel DNA methylation signature-based assay and for whom HRQoL data were also available (N = 80), were investigated in univariate analyses to assess differences between subgroups in child- and parent-reported health status (HUI), behavioural functioning (SDQ), executive functioning (BRIEF) and HRQoL (PedsQL, EORTC QLQ-C30). RESULTS: Initial analyses showed a significant overall inter-group difference in self-reported HUI (p = 0.02), due to significantly better HUI scores in the SHH (median = 1.0, p = 0.011) and Group3 (median = 0.95, p = 0.001) patient groups compared with Group4 (median = 0.72). There was also a significant overall inter-group difference in self-reported QLQ-C30 (p = 0.048), due to significantly better QLQ-C30 scores in the SHH group (median = 91.7) compared with WNT (median = 63.5, p = 0.008). SHH trended to better functioning in 3/5 other indices. CONCLUSION: These preliminary investigations seem to indicate similar findings to our previous investigation of the relationship between HRQoL and the underlying biology of medulloblastoma and provide further evidence that combined analyses of biological and HRQoL data could provide new insights into HRQoL outcomes. We plan to combine both SIOP-UKCCSG-PNET3 and HIT-SIOP-PNET4 datasets for multivariate analyses on a larger patient cohort.

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Contributors

Author: Kim Bull

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