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Amyloid: Vascular and parenchymal

Amyloid: Vascular and parenchymal
Amyloid: Vascular and parenchymal

Amyloid beta (Aßis produced in the brain throughout life and accumulates in the cerebral cortex in the elderly and to an excessive degree in Alzheimer's disease. One of the routes for elimination of Aß is by the interstitial fluid drainage pathway along basement membranes of capillary and artery walls - effectively the perivascular lymphatic drainage pathway for the brain. As arteries in the brain age they become stiffer and perivascular elimination of Aßfails, with consequent accumulation of Aß in brain parenchyma and in blood vessel walls as cerebral amyloid angiopathy. Immunotherapy is being developed to remove Aß from the brain in Alzheimer's disease.

Aging of the brain, Alzheimer's disease, Amyloid beta, Artery basement membranes, Capillary, Cerebral amyloid angiopathy, Cerebrovascular disease, Creutzfeldt-Jakob disease, Dementia, Extracellular spaces, Genetics, Interstitial fluid, Intracerebral hemorrhage, Lewy bodies, Perivascular lymphatic drainage of the brain, Synuclein, Tau protein, Vascular dementia
355-362
Elsevier Ltd.
Weller, R. O.
ae32be34-f49f-4944-bf93-19d54f3baac6
Carare, R. O.
0478c197-b0c1-4206-acae-54e88c8f21fa
Boche, D.
bdcca10e-6302-4dd0-919f-67218f7e0d61
Squire, Larry R.
Weller, R. O.
ae32be34-f49f-4944-bf93-19d54f3baac6
Carare, R. O.
0478c197-b0c1-4206-acae-54e88c8f21fa
Boche, D.
bdcca10e-6302-4dd0-919f-67218f7e0d61
Squire, Larry R.

Weller, R. O., Carare, R. O. and Boche, D. (2009) Amyloid: Vascular and parenchymal. In, Squire, Larry R. (ed.) Encyclopedia of Neuroscience. Elsevier Ltd., pp. 355-362. (doi:10.1016/B978-008045046-9.00105-4).

Record type: Book Section

Abstract

Amyloid beta (Aßis produced in the brain throughout life and accumulates in the cerebral cortex in the elderly and to an excessive degree in Alzheimer's disease. One of the routes for elimination of Aß is by the interstitial fluid drainage pathway along basement membranes of capillary and artery walls - effectively the perivascular lymphatic drainage pathway for the brain. As arteries in the brain age they become stiffer and perivascular elimination of Aßfails, with consequent accumulation of Aß in brain parenchyma and in blood vessel walls as cerebral amyloid angiopathy. Immunotherapy is being developed to remove Aß from the brain in Alzheimer's disease.

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More information

e-pub ahead of print date: 5 November 2008
Published date: 2009
Keywords: Aging of the brain, Alzheimer's disease, Amyloid beta, Artery basement membranes, Capillary, Cerebral amyloid angiopathy, Cerebrovascular disease, Creutzfeldt-Jakob disease, Dementia, Extracellular spaces, Genetics, Interstitial fluid, Intracerebral hemorrhage, Lewy bodies, Perivascular lymphatic drainage of the brain, Synuclein, Tau protein, Vascular dementia

Identifiers

Local EPrints ID: 438028
URI: http://eprints.soton.ac.uk/id/eprint/438028
PURE UUID: 64b91cb6-b32b-4805-a43a-d5606c3b70df
ORCID for R. O. Carare: ORCID iD orcid.org/0000-0001-6458-3776
ORCID for D. Boche: ORCID iD orcid.org/0000-0002-5884-130X

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Date deposited: 26 Feb 2020 17:31
Last modified: 06 Jun 2024 01:38

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Contributors

Author: R. O. Weller
Author: R. O. Carare ORCID iD
Author: D. Boche ORCID iD
Editor: Larry R. Squire

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