Amyloid: Vascular and parenchymal
Amyloid: Vascular and parenchymal
Amyloid beta (Aßis produced in the brain throughout life and accumulates in the cerebral cortex in the elderly and to an excessive degree in Alzheimer's disease. One of the routes for elimination of Aß is by the interstitial fluid drainage pathway along basement membranes of capillary and artery walls - effectively the perivascular lymphatic drainage pathway for the brain. As arteries in the brain age they become stiffer and perivascular elimination of Aßfails, with consequent accumulation of Aß in brain parenchyma and in blood vessel walls as cerebral amyloid angiopathy. Immunotherapy is being developed to remove Aß from the brain in Alzheimer's disease.
Aging of the brain, Alzheimer's disease, Amyloid beta, Artery basement membranes, Capillary, Cerebral amyloid angiopathy, Cerebrovascular disease, Creutzfeldt-Jakob disease, Dementia, Extracellular spaces, Genetics, Interstitial fluid, Intracerebral hemorrhage, Lewy bodies, Perivascular lymphatic drainage of the brain, Synuclein, Tau protein, Vascular dementia
355-362
Weller, R. O.
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Carare, R. O.
0478c197-b0c1-4206-acae-54e88c8f21fa
Boche, D.
bdcca10e-6302-4dd0-919f-67218f7e0d61
2009
Weller, R. O.
ae32be34-f49f-4944-bf93-19d54f3baac6
Carare, R. O.
0478c197-b0c1-4206-acae-54e88c8f21fa
Boche, D.
bdcca10e-6302-4dd0-919f-67218f7e0d61
Weller, R. O., Carare, R. O. and Boche, D.
(2009)
Amyloid: Vascular and parenchymal.
In,
Squire, Larry R.
(ed.)
Encyclopedia of Neuroscience.
Elsevier Ltd., .
(doi:10.1016/B978-008045046-9.00105-4).
Record type:
Book Section
Abstract
Amyloid beta (Aßis produced in the brain throughout life and accumulates in the cerebral cortex in the elderly and to an excessive degree in Alzheimer's disease. One of the routes for elimination of Aß is by the interstitial fluid drainage pathway along basement membranes of capillary and artery walls - effectively the perivascular lymphatic drainage pathway for the brain. As arteries in the brain age they become stiffer and perivascular elimination of Aßfails, with consequent accumulation of Aß in brain parenchyma and in blood vessel walls as cerebral amyloid angiopathy. Immunotherapy is being developed to remove Aß from the brain in Alzheimer's disease.
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e-pub ahead of print date: 5 November 2008
Published date: 2009
Keywords:
Aging of the brain, Alzheimer's disease, Amyloid beta, Artery basement membranes, Capillary, Cerebral amyloid angiopathy, Cerebrovascular disease, Creutzfeldt-Jakob disease, Dementia, Extracellular spaces, Genetics, Interstitial fluid, Intracerebral hemorrhage, Lewy bodies, Perivascular lymphatic drainage of the brain, Synuclein, Tau protein, Vascular dementia
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Local EPrints ID: 438028
URI: http://eprints.soton.ac.uk/id/eprint/438028
PURE UUID: 64b91cb6-b32b-4805-a43a-d5606c3b70df
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Date deposited: 26 Feb 2020 17:31
Last modified: 17 Mar 2024 02:51
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Author:
R. O. Weller
Editor:
Larry R. Squire
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