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Late Breaking Abstract - Dietary nitrate supplementation increases exercise endurance time in COPD patients using ambulatory oxygen

Late Breaking Abstract - Dietary nitrate supplementation increases exercise endurance time in COPD patients using ambulatory oxygen
Late Breaking Abstract - Dietary nitrate supplementation increases exercise endurance time in COPD patients using ambulatory oxygen
Background: Dietary nitrate supplementation reduces the oxygen cost of exercise in COPD but not endurance time (Curtis et al. 2015). Individuals using ambulatory oxygen may show a greater response. Nitric oxide (NO) regulates blood flow, mitochondrial respiration and improves pulmonary vascular resistance. Under the hypoxic conditions found in skeletal muscle of COPD patients, NO can be generated via the nitrate-nitrite-NO pathway, suggesting hypoxic patients may benefit from nitrate supplementation. Aim: To assess if dietary nitrate supplementation improves exercise endurance in COPD patients who use ambulatory oxygen. Hypothesis: Dietary nitrate supplementation will improve endurance walking time in COPD patients who need supplemental oxygen. Methods: A double blind, placebo-controlled, cross-over study comparing the effect of 140ml nitrate-rich beetroot juice (BR) with a matched placebo (PL), nitrate-depleted beetroot juice, in patients with COPD. Primary outcome measure was exercise endurance time, via the endurance shuttle walk test, assessed 3 hours after ingesting BR or PL. Results: n=20 (female 40%, age 67.6±8.5years, BMI 25.2±4.7kgm-2, FEV1 %predicted 27±8.1%). Nitrate supplementation significantly increased exercise endurance time: BR 194.6sec (89.1 – 1200.0) vs PL 159.1sec (78.6 – 785.0). Estimated treatment effect of BR vs PL 62sec (95%CI 33, 106) p
0903-1936
Pavitt, Matthew
ace9ae48-f608-4819-a261-6105e364b0d9
Lewis, Adam P.
4c3eefcd-e5c3-46be-9004-91fd706ec385
Buttery, Sara C.
a93f2fbc-4c73-4b9d-82c0-95a19a8b6aa0
Fernandez, Bernadette O.
9890aabc-1fe6-4530-a51e-31182e537131
Mikus-Lelinska, Monika
6ca48669-ff8f-4ae8-9d10-98c74327b4ec
Feelisch, Martin
8c1b9965-8614-4e85-b2c6-458a2e17eafd
Polkey, Michael I.
4f841dc9-9b94-4021-bbfc-64092cddc7b6
Hopkinson, Nicholas S.
91e9a2af-8ab3-4671-b766-761e82bd5310
Pavitt, Matthew
ace9ae48-f608-4819-a261-6105e364b0d9
Lewis, Adam P.
4c3eefcd-e5c3-46be-9004-91fd706ec385
Buttery, Sara C.
a93f2fbc-4c73-4b9d-82c0-95a19a8b6aa0
Fernandez, Bernadette O.
9890aabc-1fe6-4530-a51e-31182e537131
Mikus-Lelinska, Monika
6ca48669-ff8f-4ae8-9d10-98c74327b4ec
Feelisch, Martin
8c1b9965-8614-4e85-b2c6-458a2e17eafd
Polkey, Michael I.
4f841dc9-9b94-4021-bbfc-64092cddc7b6
Hopkinson, Nicholas S.
91e9a2af-8ab3-4671-b766-761e82bd5310

Pavitt, Matthew, Lewis, Adam P., Buttery, Sara C., Fernandez, Bernadette O., Mikus-Lelinska, Monika, Feelisch, Martin, Polkey, Michael I. and Hopkinson, Nicholas S. (2018) Late Breaking Abstract - Dietary nitrate supplementation increases exercise endurance time in COPD patients using ambulatory oxygen. European Respiratory Journal, 52 (Supplement 52), [PA4049]. (doi:10.1183/13993003.congress-2018.pa4049).

Record type: Meeting abstract

Abstract

Background: Dietary nitrate supplementation reduces the oxygen cost of exercise in COPD but not endurance time (Curtis et al. 2015). Individuals using ambulatory oxygen may show a greater response. Nitric oxide (NO) regulates blood flow, mitochondrial respiration and improves pulmonary vascular resistance. Under the hypoxic conditions found in skeletal muscle of COPD patients, NO can be generated via the nitrate-nitrite-NO pathway, suggesting hypoxic patients may benefit from nitrate supplementation. Aim: To assess if dietary nitrate supplementation improves exercise endurance in COPD patients who use ambulatory oxygen. Hypothesis: Dietary nitrate supplementation will improve endurance walking time in COPD patients who need supplemental oxygen. Methods: A double blind, placebo-controlled, cross-over study comparing the effect of 140ml nitrate-rich beetroot juice (BR) with a matched placebo (PL), nitrate-depleted beetroot juice, in patients with COPD. Primary outcome measure was exercise endurance time, via the endurance shuttle walk test, assessed 3 hours after ingesting BR or PL. Results: n=20 (female 40%, age 67.6±8.5years, BMI 25.2±4.7kgm-2, FEV1 %predicted 27±8.1%). Nitrate supplementation significantly increased exercise endurance time: BR 194.6sec (89.1 – 1200.0) vs PL 159.1sec (78.6 – 785.0). Estimated treatment effect of BR vs PL 62sec (95%CI 33, 106) p

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Published date: 15 September 2018

Identifiers

Local EPrints ID: 438459
URI: http://eprints.soton.ac.uk/id/eprint/438459
ISSN: 0903-1936
PURE UUID: bcceaa13-0fe4-4439-afd1-00999ca3b9a2
ORCID for Bernadette O. Fernandez: ORCID iD orcid.org/0000-0001-6337-0381
ORCID for Martin Feelisch: ORCID iD orcid.org/0000-0003-2320-1158

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Date deposited: 10 Mar 2020 17:32
Last modified: 18 Feb 2021 17:20

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Contributors

Author: Matthew Pavitt
Author: Adam P. Lewis
Author: Sara C. Buttery
Author: Bernadette O. Fernandez ORCID iD
Author: Monika Mikus-Lelinska
Author: Martin Feelisch ORCID iD
Author: Michael I. Polkey
Author: Nicholas S. Hopkinson

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