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Psychological stress, cognitive decline and the development of dementia in amnestic mild cognitive impairment

Psychological stress, cognitive decline and the development of dementia in amnestic mild cognitive impairment
Psychological stress, cognitive decline and the development of dementia in amnestic mild cognitive impairment

To determine the relationship between psychological stress with cognitive outcomes in a multi-centre longitudinal study of people with amnestic mild cognitive impairment (aMCI) we assessed three parameters of psychological stress (Recent Life Changes Questionnaire (RLCQ); the Perceived Stress Scale (PSS) and salivary cortisol) and their relationship with rates of cognitive decline over an 18 month follow up period and conversion to dementia over a 5.5 year period. In 133 aMCI and 68 cognitively intact participants the PSS score was higher in the aMCI compared with control group but neither the RLCQ scores nor salivary cortisol measures were different between groups. In the aMCI group the RLCQ and the PSS showed no significant association with cognitive function at baseline, cognitive decline or with conversion rates to dementia but high salivary cortisol levels were associated with RLCQ scores and poorer cognitive function at baseline and lower rates of cognitive decline. No relationship was found between salivary cortisol levels and conversion rate to dementia. We conclude that psychological stress as measured by the RLCQ or PSS was not associated with adverse cognitive outcomes in an aMCI population and hypothesise that this may reflect diminished cortisol production to psychological stress as the disease progresses.

2045-2322
Sussams, Rebecca
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Schlotz, Wolff
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Clough, Zoe
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Amin, Jay
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Simpson, Sharon
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Abbott, Amelia
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Beardmore, Rebecca
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Sharples, Richard
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Raybould, Rachel
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Brookes, Keeley
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Morgan, Kevin
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Culliford, David
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Holmes, Clive
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Sussams, Rebecca
7730c148-943d-4d97-b3c4-02e157bcc178
Schlotz, Wolff
49499d5e-4ff4-4ad3-b5f7-eec11b25b5db
Clough, Zoe
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Amin, Jay
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Simpson, Sharon
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Abbott, Amelia
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Beardmore, Rebecca
cf4540a1-d1b1-4208-b0f4-d647210e9a0d
Sharples, Richard
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Raybould, Rachel
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Brookes, Keeley
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Morgan, Kevin
f4a865c9-f8cc-443c-a2e7-3e3ac5a8cf85
Culliford, David
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Holmes, Clive
ada5abf3-8459-4cf7-be40-3f4e9391cc96

Sussams, Rebecca, Schlotz, Wolff, Clough, Zoe, Amin, Jay, Simpson, Sharon, Abbott, Amelia, Beardmore, Rebecca, Sharples, Richard, Raybould, Rachel, Brookes, Keeley, Morgan, Kevin, Culliford, David and Holmes, Clive (2020) Psychological stress, cognitive decline and the development of dementia in amnestic mild cognitive impairment. Scientific Reports, 10 (1), [3618]. (doi:10.1038/s41598-020-60607-0).

Record type: Article

Abstract

To determine the relationship between psychological stress with cognitive outcomes in a multi-centre longitudinal study of people with amnestic mild cognitive impairment (aMCI) we assessed three parameters of psychological stress (Recent Life Changes Questionnaire (RLCQ); the Perceived Stress Scale (PSS) and salivary cortisol) and their relationship with rates of cognitive decline over an 18 month follow up period and conversion to dementia over a 5.5 year period. In 133 aMCI and 68 cognitively intact participants the PSS score was higher in the aMCI compared with control group but neither the RLCQ scores nor salivary cortisol measures were different between groups. In the aMCI group the RLCQ and the PSS showed no significant association with cognitive function at baseline, cognitive decline or with conversion rates to dementia but high salivary cortisol levels were associated with RLCQ scores and poorer cognitive function at baseline and lower rates of cognitive decline. No relationship was found between salivary cortisol levels and conversion rate to dementia. We conclude that psychological stress as measured by the RLCQ or PSS was not associated with adverse cognitive outcomes in an aMCI population and hypothesise that this may reflect diminished cortisol production to psychological stress as the disease progresses.

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Accepted/In Press date: 10 February 2020
Published date: 27 February 2020

Identifiers

Local EPrints ID: 438462
URI: http://eprints.soton.ac.uk/id/eprint/438462
ISSN: 2045-2322
PURE UUID: bbca8d6d-4644-4b42-a079-62049d8c6c1f
ORCID for Jay Amin: ORCID iD orcid.org/0000-0003-3792-0428
ORCID for Clive Holmes: ORCID iD orcid.org/0000-0003-1999-6912

Catalogue record

Date deposited: 10 Mar 2020 17:33
Last modified: 26 Nov 2021 03:03

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Contributors

Author: Rebecca Sussams
Author: Wolff Schlotz
Author: Zoe Clough
Author: Jay Amin ORCID iD
Author: Sharon Simpson
Author: Amelia Abbott
Author: Rebecca Beardmore
Author: Richard Sharples
Author: Rachel Raybould
Author: Keeley Brookes
Author: Kevin Morgan
Author: David Culliford
Author: Clive Holmes ORCID iD

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