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A decade of FRAX: how has it changed the management of osteoporosis?

A decade of FRAX: how has it changed the management of osteoporosis?
A decade of FRAX: how has it changed the management of osteoporosis?
The fracture risk assessment tool, FRAX®, was released in 2008 and provides country-specific algorithms for estimating individualized 10-year probability of hip and major osteoporotic fracture (hip, clinical spine, distal forearm, and proximal humerus). Since its release, 71 models have been made available for 66 countries covering more than 80% of the world population. The website receives approximately 3 million visits annually. Following independent validation, FRAX has been incorporated into more than 80 guidelines worldwide. The application of FRAX in assessment guidelines has been heterogeneous with the adoption of several different approaches in setting intervention thresholds. Whereas most guidelines adopt a case-finding strategy, the case for FRAX-based community screening in the elderly is increasing. The relationship between FRAX and efficacy of intervention has been explored and is expected to influence treatment guidelines in the future.
Clinical risk factors, FRAX, Fracture probability, Intervention thresholds, Risk assessment, Screening
1594-0667
187-196
Kanis, John A.
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Harvey, Nicholas C.
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Johansson, Helena
04f12338-4dd1-437b-b9bc-e0884130c215
Liu, Enwu
08027c15-9e71-44bb-9623-3081f5f6492d
Vandenput, Liesbeth
0910d143-4b58-4579-82b0-3810272f1814
Lorentzon, Mattias
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Leslie, William D.
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Mccloskey, Eugene V.
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Kanis, John A.
f1621d8d-8afb-4d97-9679-2165d88a344d
Harvey, Nicholas C.
ce487fb4-d360-4aac-9d17-9466d6cba145
Johansson, Helena
04f12338-4dd1-437b-b9bc-e0884130c215
Liu, Enwu
08027c15-9e71-44bb-9623-3081f5f6492d
Vandenput, Liesbeth
0910d143-4b58-4579-82b0-3810272f1814
Lorentzon, Mattias
9d78ed25-2b0c-46c5-a2db-a8b246af0956
Leslie, William D.
5b2dd5d6-4569-40a3-a9b1-95152d11e4f1
Mccloskey, Eugene V.
2f057a16-3d4e-4597-80c7-6ce47f969c78

Kanis, John A., Harvey, Nicholas C., Johansson, Helena, Liu, Enwu, Vandenput, Liesbeth, Lorentzon, Mattias, Leslie, William D. and Mccloskey, Eugene V. (2020) A decade of FRAX: how has it changed the management of osteoporosis? Aging Clinical and Experimental Research, 32 (2), 187-196. (doi:10.1007/s40520-019-01432-y).

Record type: Article

Abstract

The fracture risk assessment tool, FRAX®, was released in 2008 and provides country-specific algorithms for estimating individualized 10-year probability of hip and major osteoporotic fracture (hip, clinical spine, distal forearm, and proximal humerus). Since its release, 71 models have been made available for 66 countries covering more than 80% of the world population. The website receives approximately 3 million visits annually. Following independent validation, FRAX has been incorporated into more than 80 guidelines worldwide. The application of FRAX in assessment guidelines has been heterogeneous with the adoption of several different approaches in setting intervention thresholds. Whereas most guidelines adopt a case-finding strategy, the case for FRAX-based community screening in the elderly is increasing. The relationship between FRAX and efficacy of intervention has been explored and is expected to influence treatment guidelines in the future.

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ACER FRAX review v3 - Accepted Manuscript
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Accepted/In Press date: 21 November 2019
e-pub ahead of print date: 11 February 2020
Keywords: Clinical risk factors, FRAX, Fracture probability, Intervention thresholds, Risk assessment, Screening

Identifiers

Local EPrints ID: 438472
URI: http://eprints.soton.ac.uk/id/eprint/438472
ISSN: 1594-0667
PURE UUID: 2958d884-bfe2-4aa5-9f11-6e8271834aa8
ORCID for Nicholas C. Harvey: ORCID iD orcid.org/0000-0002-8194-2512

Catalogue record

Date deposited: 11 Mar 2020 17:30
Last modified: 26 Nov 2021 02:48

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Contributors

Author: John A. Kanis
Author: Helena Johansson
Author: Enwu Liu
Author: Liesbeth Vandenput
Author: Mattias Lorentzon
Author: William D. Leslie
Author: Eugene V. Mccloskey

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