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Refining rodent models of spinal cord injury

Refining rodent models of spinal cord injury
Refining rodent models of spinal cord injury
This report was produced by an Expert Working Group (EWG) consisting of UK-based researchers, veterinarians and regulators of animal experiments with specialist knowledge of the use of animal models of spinal cord injury (SCI). It aims to facilitate the implementation of the Three Rs (Replacement, Reduction and Refinement), with an emphasis on refinement. Specific animal welfare issues were identified and discussed, and practical measures proposed, with the aim of reducing animal use and suffering, reducing experimental variability, and increasing translatability within this critically important research field.
Animal model, Animal welfare, Paralysis, Refinement, Regeneration, Spinal contusion, Spinal cord injury, Spinal transection, Three Rs, Tissue repair, Translational research
0014-4886
1-12
Lilley, Elliot
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Andrews, Melissa
ae987a2f-878e-4ae3-a7a3-a7170712096c
Bradbury, Elizabeth
6a71bb1a-7317-4fed-b041-e6054a4ecffe
Elliot, Heather
02e36dcd-d38c-43e7-bbe2-0db0393fb5e2
Hawkins, Penny
6f0b60b4-725c-46c8-b4ce-b9eabbddc90f
Ichiyama, Ronaldo
1d399668-2057-4cb7-a49c-db9f1d721be4
Keeley, Jo
637fcf27-ab1d-4201-bd28-43aac3153ccd
Michael-Titus, Adina
fdd7e42a-23fe-48e1-a0ba-1ea2426258a1
Moon, Lawrence
79f0d787-e83b-4e70-a14a-55fbc9cfe28c
Pluchino, Stefano
63d68307-e8bd-4edd-8436-4fbd7dd3f644
Riddell, John
e8ec1109-9a4d-4be7-af08-51319ef0dc4f
Ryder, Kathy
d9376b85-2161-4187-a22a-e5c11f59cf29
Yip, Ping
90ab2446-ea67-42dc-9f45-6ff27123304d
Lilley, Elliot
4bdc4189-c050-4403-985d-46cb92b2ab30
Andrews, Melissa
ae987a2f-878e-4ae3-a7a3-a7170712096c
Bradbury, Elizabeth
6a71bb1a-7317-4fed-b041-e6054a4ecffe
Elliot, Heather
02e36dcd-d38c-43e7-bbe2-0db0393fb5e2
Hawkins, Penny
6f0b60b4-725c-46c8-b4ce-b9eabbddc90f
Ichiyama, Ronaldo
1d399668-2057-4cb7-a49c-db9f1d721be4
Keeley, Jo
637fcf27-ab1d-4201-bd28-43aac3153ccd
Michael-Titus, Adina
fdd7e42a-23fe-48e1-a0ba-1ea2426258a1
Moon, Lawrence
79f0d787-e83b-4e70-a14a-55fbc9cfe28c
Pluchino, Stefano
63d68307-e8bd-4edd-8436-4fbd7dd3f644
Riddell, John
e8ec1109-9a4d-4be7-af08-51319ef0dc4f
Ryder, Kathy
d9376b85-2161-4187-a22a-e5c11f59cf29
Yip, Ping
90ab2446-ea67-42dc-9f45-6ff27123304d

Lilley, Elliot, Andrews, Melissa, Bradbury, Elizabeth, Elliot, Heather, Hawkins, Penny, Ichiyama, Ronaldo, Keeley, Jo, Michael-Titus, Adina, Moon, Lawrence, Pluchino, Stefano, Riddell, John, Ryder, Kathy and Yip, Ping (2020) Refining rodent models of spinal cord injury. Experimental Neurology, 328, 1-12, [113273]. (doi:10.1016/j.expneurol.2020.113273).

Record type: Review

Abstract

This report was produced by an Expert Working Group (EWG) consisting of UK-based researchers, veterinarians and regulators of animal experiments with specialist knowledge of the use of animal models of spinal cord injury (SCI). It aims to facilitate the implementation of the Three Rs (Replacement, Reduction and Refinement), with an emphasis on refinement. Specific animal welfare issues were identified and discussed, and practical measures proposed, with the aim of reducing animal use and suffering, reducing experimental variability, and increasing translatability within this critically important research field.

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Accepted/In Press date: 2 March 2020
e-pub ahead of print date: 3 March 2020
Published date: June 2020
Additional Information: Funding Information: We would like to thank Shelly McErlane DVM, senior clinical veterinarian, Centre for Comparative Medicine, The University of British Columbia, Canada for allowing us to publish a modified version of the welfare assessment scheme she kindly shared with us (Table 5). Publisher Copyright: © 2020 The Authors
Keywords: Animal model, Animal welfare, Paralysis, Refinement, Regeneration, Spinal contusion, Spinal cord injury, Spinal transection, Three Rs, Tissue repair, Translational research
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Identifiers

Local EPrints ID: 438557
URI: http://eprints.soton.ac.uk/id/eprint/438557
DOI: doi:10.1016/j.expneurol.2020.113273
ISSN: 0014-4886
PURE UUID: 238f9fdc-fae2-4845-88d0-0414ea2128f7
ORCID for Melissa Andrews: ORCID iD orcid.org/0000-0001-5960-5619

Catalogue record

Date deposited: 17 Mar 2020 17:30
Last modified: 17 Mar 2024 03:44

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Contributors

Author: Elliot Lilley
Author: Melissa Andrews ORCID iD
Author: Elizabeth Bradbury
Author: Heather Elliot
Author: Penny Hawkins
Author: Ronaldo Ichiyama
Author: Jo Keeley
Author: Adina Michael-Titus
Author: Lawrence Moon
Author: Stefano Pluchino
Author: John Riddell
Author: Kathy Ryder
Author: Ping Yip

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