Intravascular imaging and 12-month mortality after unprotected left main stem PCI: An analysis From the British Cardiovascular Intervention Society Database

Kinnaird, Tim, Johnson, Thomas, Anderson, Richard, Gallagher, Sean, Sirker, Alex, Ludman, Peter, de Belder, Mark, Copt, Samuel, Oldroyd, Keith, Banning, Adrian, Mamas, Mamas and Curzen, Nicholas (2020) Intravascular imaging and 12-month mortality after unprotected left main stem PCI: An analysis From the British Cardiovascular Intervention Society Database. JACC Cardiovascular Interventions, 13 (3), 346-357. (doi:10.1016/j.jcin.2019.10.007).

Abstract

OBJECTIVES: The authors used the British Cardiovascular Intervention Society (BCIS) national percutaneous coronary intervention (PCI) database to explore temporal changes in the use of intravascular imaging for unprotected left main stem PCI (uLMS PCI), defined the associates of imaging use, and correlate clinical outcomes including survival with imaging use.

BACKGROUND: Limited registry data support the use of intravascular imaging during uLMS PCI to improve outcomes.

METHODS: Data were analyzed from 11,264 uLMS PCI procedures performed in England and Wales between 2007 and 2014. Multivariate logistic regression was used to identify associates of imaging use. Propensity matching created 5,056 pairs of subjects with and without imaging and logistic regression was performed to quantify the association between imaging and outcomes. Multivariate logistic regression to identify the independent predictors of 12-month mortality was performed.

RESULTS: Imaging use increased from 30.2% in 2007 to 50.2% in 2014 (p for trend < 0.001). The factors associated with imaging use included stable angina presentation (odds ratio [OR]: 1.200; 95% confidence interval [CI]: 1.147 to 1.246; p < 0.001), bifurcation LMS disease (OR: 1.220; 95% CI: 1.140 to 1.300; p < 0.001), previous PCI (OR: 1.320; 95% CI: 1.200 to 1.440; p < 0.001), and radial access (OR: 1.266; 95% CI: 1.217 to 1.317; p < 0.001). A lower rate of coronary complications, lower in-hospital major adverse cardiac events (OR: 0.470; 95% CI: 0.37 to 0.590; p < 0.001), and improved 30-day (OR: 0.540; 95% CI: 0.430 to 0.680; p < 0.001) and 12-month (OR: 0.660; 95% CI: 0.570 to 0.770; p < 0.001) mortality were observed with imaging use compared with no imaging use. Greater mortality reductions were observed with higher operator LMS PCI volume. In logistic regression modeling, imaging use was associated with improved 12-month survival.

CONCLUSIONS: The observed lower mortality with use of intravascular imaging to guide uLMS PCI justifies the undertaking of a large-scale randomized trial.

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Contributors

Author: Nicholas Curzen

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