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Ophthalmology research in the UK’s National Health Service: the structure and performance of the NIHR’s Ophthalmology research portfolio

Ophthalmology research in the UK’s National Health Service: the structure and performance of the NIHR’s Ophthalmology research portfolio
Ophthalmology research in the UK’s National Health Service: the structure and performance of the NIHR’s Ophthalmology research portfolio

Purpose: To report on the composition and performance of the portfolio of Ophthalmology research studies in the United Kingdom’s National Institute for Health Research (NIHR) Clinical Research Network (UK CRN). Methods: Ophthalmology studies open to recruitment between 1 April 2010 and 31 March 2018 were classified by: sub-specialty, participant age, gender of Chief Investigator, involvement of genetic investigations, commercial/ non-commercial, interventional/observational design. Frequency distributions for each covariate and temporal variation in recruitment to time and target were analysed. Results: Over 8 years, 137,377 participants were recruited (average of 15,457 participants/year; range: 5485–32,573) with growth by year in proportion of commercial studies and hospital participation in England (76% in 2017/18). Fourteen percent of studies had a genetic component and most studies (82%) included only adults. The majority of studies (41%) enrolled patients with retinal diseases, followed by glaucoma (17%), anterior segment and cataract (13%), and ocular inflammation (6%). Overall, 68% of non-commercial studies and 55% of commercial studies recruited within the anticipated time set by the study and also recruited to or exceeded the target number of participants. Conclusions: High levels of clinical research activity, growth and improved performance have been observed in Ophthalmology in UK over the past 8 years. Some sub-specialties that carry substantial morbidity and a very high burden on NHS services are underrepresented and deserve more patient-centred research. Yet the NIHR and its CRN Ophthalmology National Specialty Group has enabled key steps in achieving the goal of embedding research into every day clinical care.

0950-222X
610-618
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Gale, Richard
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McKibbin, Martin
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Membrey, Luke
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Mulholland, Pádraig J.
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Patel, Nishal
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Sung, Velota
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NIHR Ophthalmology Specialty Group
Dawson, Sarah R.
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Linton, Emma
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Beicher, Kris
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Gale, Richard
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Patel, Praveen
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Ghanchi, Faruque
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Beresford, Michael W.
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Poustie, Vanessa
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Chakravarthy, Usha
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Bourne, Rupert R.A.
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Downes, Susan
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Downey, Louise
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Cooper, Sarah
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Hoad, Geraldine
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Acton, Michele
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Gow, Louise
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Broom, Matt
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Dickinson, Christine
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Dawson, Sarah R., Linton, Emma, Beicher, Kris, Gale, Richard, Patel, Praveen, Ghanchi, Faruque, Beresford, Michael W., Poustie, Vanessa, Chakravarthy, Usha and Bourne, Rupert R.A. , NIHR Ophthalmology Specialty Group (2019) Ophthalmology research in the UK’s National Health Service: the structure and performance of the NIHR’s Ophthalmology research portfolio. Eye (Basingstoke), 33 (4), 610-618. (doi:10.1038/s41433-018-0251-8).

Record type: Article

Abstract

Purpose: To report on the composition and performance of the portfolio of Ophthalmology research studies in the United Kingdom’s National Institute for Health Research (NIHR) Clinical Research Network (UK CRN). Methods: Ophthalmology studies open to recruitment between 1 April 2010 and 31 March 2018 were classified by: sub-specialty, participant age, gender of Chief Investigator, involvement of genetic investigations, commercial/ non-commercial, interventional/observational design. Frequency distributions for each covariate and temporal variation in recruitment to time and target were analysed. Results: Over 8 years, 137,377 participants were recruited (average of 15,457 participants/year; range: 5485–32,573) with growth by year in proportion of commercial studies and hospital participation in England (76% in 2017/18). Fourteen percent of studies had a genetic component and most studies (82%) included only adults. The majority of studies (41%) enrolled patients with retinal diseases, followed by glaucoma (17%), anterior segment and cataract (13%), and ocular inflammation (6%). Overall, 68% of non-commercial studies and 55% of commercial studies recruited within the anticipated time set by the study and also recruited to or exceeded the target number of participants. Conclusions: High levels of clinical research activity, growth and improved performance have been observed in Ophthalmology in UK over the past 8 years. Some sub-specialties that carry substantial morbidity and a very high burden on NHS services are underrepresented and deserve more patient-centred research. Yet the NIHR and its CRN Ophthalmology National Specialty Group has enabled key steps in achieving the goal of embedding research into every day clinical care.

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More information

Accepted/In Press date: 30 September 2018
e-pub ahead of print date: 20 November 2018
Published date: 1 April 2019

Identifiers

Local EPrints ID: 438701
URI: http://eprints.soton.ac.uk/id/eprint/438701
ISSN: 0950-222X
PURE UUID: d8e2de45-849d-4e43-9e56-cf6cba3110ae
ORCID for Andrew Lotery: ORCID iD orcid.org/0000-0001-5541-4305

Catalogue record

Date deposited: 23 Mar 2020 17:30
Last modified: 22 Oct 2021 01:38

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Contributors

Author: Sarah R. Dawson
Author: Emma Linton
Author: Kris Beicher
Author: Richard Gale
Author: Praveen Patel
Author: Faruque Ghanchi
Author: Michael W. Beresford
Author: Vanessa Poustie
Author: Usha Chakravarthy
Author: Rupert R.A. Bourne
Author: Jane Ashworth
Author: Clare Bailey
Author: Susan Downes
Author: Louise Downey
Author: Sheena George
Author: Irene Gottlob
Author: Christopher Hammond
Author: Simon Harding
Author: Jonathan Jackson
Author: Andrew Lotery ORCID iD
Author: Martin McKibbin
Author: Luke Membrey
Author: Pádraig J. Mulholland
Author: Nishal Patel
Author: George M. Saleh
Author: Roshini Sanders
Author: Giuliana Silvestri
Author: Velota Sung
Author: Deepali Varma
Author: Marcella Votruba
Author: Emma Worrell
Author: Brinda Shah
Author: Ian Nickson
Author: Michael Beresford
Author: Vanessa Poustie
Author: Emma Chambers
Author: Sarah Cooper
Author: Cathy Yelf
Author: Geraldine Hoad
Author: Michele Acton
Author: Louise Gow
Author: Matt Broom
Author: Christine Dickinson
Author: Padraig Mulholland
Author: Manjo Doug
Author: Robert Barry
Corporate Author: NIHR Ophthalmology Specialty Group

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