Antimicrobial activity of the quinoline derivative HT61 against Staphylococcus aureus biofilms
Antimicrobial activity of the quinoline derivative HT61 against Staphylococcus aureus biofilms
Staphylococcus aureus biofilms are a significant problem in health care settings, partly due to the presence of a nondividing, antibiotic-tolerant subpopulation. Here we evaluated treatment of S. aureus UAMS-1 biofilms with HT61, a quinoline derivative shown to be effective against nondividing Staphylococcus spp. HT61 was effective at reducing biofilm viability and was associated with increased expression of cell wall stress and division proteins, confirming its potential as a treatment for S. aureus biofilm infections.
Antibiotics, Biofilms, HT61, Proteomics, Staphylococcus aureus
Frapwell, C.J.
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Skipp, P.J.
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Howlin, R.P.
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Angus, E.M.
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Hu, Y
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Coates, A.R.M.
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Allan, R.N.
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Webb, J.S.
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21 April 2020
Frapwell, C.J.
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Skipp, P.J.
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Howlin, R.P.
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Angus, E.M.
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Hu, Y
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Coates, A.R.M.
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Allan, R.N.
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Webb, J.S.
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Frapwell, C.J., Skipp, P.J., Howlin, R.P., Angus, E.M., Hu, Y, Coates, A.R.M., Allan, R.N. and Webb, J.S.
(2020)
Antimicrobial activity of the quinoline derivative HT61 against Staphylococcus aureus biofilms.
Antimicrobial Agents and Chemotherapy, 64 (5), [e02073-19].
(doi:10.1128/AAC.02073-19).
Abstract
Staphylococcus aureus biofilms are a significant problem in health care settings, partly due to the presence of a nondividing, antibiotic-tolerant subpopulation. Here we evaluated treatment of S. aureus UAMS-1 biofilms with HT61, a quinoline derivative shown to be effective against nondividing Staphylococcus spp. HT61 was effective at reducing biofilm viability and was associated with increased expression of cell wall stress and division proteins, confirming its potential as a treatment for S. aureus biofilm infections.
Text
Antimicrobial Agents and Chemotherapy-2020-Frapwell-AAC.02073-19.full
- Accepted Manuscript
More information
Accepted/In Press date: 25 February 2020
e-pub ahead of print date: 21 April 2020
Published date: 21 April 2020
Additional Information:
Copyright © 2020 Frapwell et al.
Keywords:
Antibiotics, Biofilms, HT61, Proteomics, Staphylococcus aureus
Identifiers
Local EPrints ID: 438728
URI: http://eprints.soton.ac.uk/id/eprint/438728
ISSN: 0066-4804
PURE UUID: 4744dfdc-9dd5-484e-b88f-fe32938c5211
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Date deposited: 23 Mar 2020 17:31
Last modified: 17 Mar 2024 03:07
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Contributors
Author:
C.J. Frapwell
Author:
R.P. Howlin
Author:
E.M. Angus
Author:
Y Hu
Author:
A.R.M. Coates
Author:
R.N. Allan
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