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Antimicrobial activity of the quinoline derivative HT61 against Staphylococcus aureus biofilms

Antimicrobial activity of the quinoline derivative HT61 against Staphylococcus aureus biofilms
Antimicrobial activity of the quinoline derivative HT61 against Staphylococcus aureus biofilms
Staphylococcus aureus biofilms are a significant problem in healthcare settings, in part, owing to the presence of a non-dividing, antibiotic tolerant sub-population. Here we evaluated treatment of S. aureus UAMS-1 biofilms with HT61, a quinoline derivative shown to be effective against non-dividing Staphylococcal spp. HT61 was effective in reducing biofilm viability, associated with increased expression of cell wall stress and division proteins, confirming its potential as a treatment for S. aureus biofilm infections.
Antibiotics, Biofilms, HT61, Proteomics, Staphylococcus aureus
0066-4804
Frapwell, C.J.
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Skipp, P.J.
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Howlin, R.P.
1be070be-3a92-4b79-8fa6-e06d4cbb6013
Angus, E.M.
a911c031-be90-4f89-9c65-405df5afb28f
Hu, Y
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Coates, A.R.M.
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Allan, R.N.
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Webb, J.S.
ec0a5c4e-86cc-4ae9-b390-7298f5d65f8d
Frapwell, C.J.
687070ab-1e5c-46ef-8450-9f3f5a566e7f
Skipp, P.J.
1ba7dcf6-9fe7-4b5c-a9d0-e32ed7f42aa5
Howlin, R.P.
1be070be-3a92-4b79-8fa6-e06d4cbb6013
Angus, E.M.
a911c031-be90-4f89-9c65-405df5afb28f
Hu, Y
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Coates, A.R.M.
c60f45be-2ea0-4157-9362-c51275591bf6
Allan, R.N.
b4579866-5280-4ed9-b54f-a96ef761bfc9
Webb, J.S.
ec0a5c4e-86cc-4ae9-b390-7298f5d65f8d

Frapwell, C.J., Skipp, P.J., Howlin, R.P., Angus, E.M., Hu, Y, Coates, A.R.M., Allan, R.N. and Webb, J.S. (2020) Antimicrobial activity of the quinoline derivative HT61 against Staphylococcus aureus biofilms. Antimicrobial Agents and Chemotherapy, 64 (5), [e02073-19]. (doi:10.1128/AAC.02073-19).

Record type: Article

Abstract

Staphylococcus aureus biofilms are a significant problem in healthcare settings, in part, owing to the presence of a non-dividing, antibiotic tolerant sub-population. Here we evaluated treatment of S. aureus UAMS-1 biofilms with HT61, a quinoline derivative shown to be effective against non-dividing Staphylococcal spp. HT61 was effective in reducing biofilm viability, associated with increased expression of cell wall stress and division proteins, confirming its potential as a treatment for S. aureus biofilm infections.

Text
Antimicrobial Agents and Chemotherapy-2020-Frapwell-AAC.02073-19.full - Accepted Manuscript
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More information

Accepted/In Press date: 25 February 2020
e-pub ahead of print date: 21 April 2020
Keywords: Antibiotics, Biofilms, HT61, Proteomics, Staphylococcus aureus

Identifiers

Local EPrints ID: 438728
URI: http://eprints.soton.ac.uk/id/eprint/438728
ISSN: 0066-4804
PURE UUID: 4744dfdc-9dd5-484e-b88f-fe32938c5211
ORCID for P.J. Skipp: ORCID iD orcid.org/0000-0002-2995-2959
ORCID for J.S. Webb: ORCID iD orcid.org/0000-0003-2068-8589

Catalogue record

Date deposited: 23 Mar 2020 17:31
Last modified: 13 Apr 2021 01:42

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