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Antimicrobial activity of the quinoline derivative HT61 against Staphylococcus aureus biofilms

Antimicrobial activity of the quinoline derivative HT61 against Staphylococcus aureus biofilms
Antimicrobial activity of the quinoline derivative HT61 against Staphylococcus aureus biofilms

Staphylococcus aureus biofilms are a significant problem in health care settings, partly due to the presence of a nondividing, antibiotic-tolerant subpopulation. Here we evaluated treatment of S. aureus UAMS-1 biofilms with HT61, a quinoline derivative shown to be effective against nondividing Staphylococcus spp. HT61 was effective at reducing biofilm viability and was associated with increased expression of cell wall stress and division proteins, confirming its potential as a treatment for S. aureus biofilm infections.

Antibiotics, Biofilms, HT61, Proteomics, Staphylococcus aureus
0066-4804
Frapwell, C.J.
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Skipp, P.J.
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Howlin, R.P.
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Angus, E.M.
a911c031-be90-4f89-9c65-405df5afb28f
Hu, Y
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Coates, A.R.M.
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Allan, R.N.
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Webb, J.S.
ec0a5c4e-86cc-4ae9-b390-7298f5d65f8d
Frapwell, C.J.
687070ab-1e5c-46ef-8450-9f3f5a566e7f
Skipp, P.J.
1ba7dcf6-9fe7-4b5c-a9d0-e32ed7f42aa5
Howlin, R.P.
1be070be-3a92-4b79-8fa6-e06d4cbb6013
Angus, E.M.
a911c031-be90-4f89-9c65-405df5afb28f
Hu, Y
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Coates, A.R.M.
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Allan, R.N.
b4579866-5280-4ed9-b54f-a96ef761bfc9
Webb, J.S.
ec0a5c4e-86cc-4ae9-b390-7298f5d65f8d

Frapwell, C.J., Skipp, P.J., Howlin, R.P., Angus, E.M., Hu, Y, Coates, A.R.M., Allan, R.N. and Webb, J.S. (2020) Antimicrobial activity of the quinoline derivative HT61 against Staphylococcus aureus biofilms. Antimicrobial Agents and Chemotherapy, 64 (5), [e02073-19]. (doi:10.1128/AAC.02073-19).

Record type: Article

Abstract

Staphylococcus aureus biofilms are a significant problem in health care settings, partly due to the presence of a nondividing, antibiotic-tolerant subpopulation. Here we evaluated treatment of S. aureus UAMS-1 biofilms with HT61, a quinoline derivative shown to be effective against nondividing Staphylococcus spp. HT61 was effective at reducing biofilm viability and was associated with increased expression of cell wall stress and division proteins, confirming its potential as a treatment for S. aureus biofilm infections.

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Antimicrobial Agents and Chemotherapy-2020-Frapwell-AAC.02073-19.full - Accepted Manuscript
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More information

Accepted/In Press date: 25 February 2020
e-pub ahead of print date: 21 April 2020
Published date: 21 April 2020
Additional Information: Copyright © 2020 Frapwell et al.
Keywords: Antibiotics, Biofilms, HT61, Proteomics, Staphylococcus aureus

Identifiers

Local EPrints ID: 438728
URI: http://eprints.soton.ac.uk/id/eprint/438728
ISSN: 0066-4804
PURE UUID: 4744dfdc-9dd5-484e-b88f-fe32938c5211
ORCID for P.J. Skipp: ORCID iD orcid.org/0000-0002-2995-2959
ORCID for J.S. Webb: ORCID iD orcid.org/0000-0003-2068-8589

Catalogue record

Date deposited: 23 Mar 2020 17:31
Last modified: 23 Jul 2022 01:56

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Contributors

Author: C.J. Frapwell
Author: P.J. Skipp ORCID iD
Author: R.P. Howlin
Author: E.M. Angus
Author: Y Hu
Author: A.R.M. Coates
Author: R.N. Allan
Author: J.S. Webb ORCID iD

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