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Systemic and ocular determinants of peripapillary retinal nerve fiber layer thickness measurements in the European Eye Epidemiology (e3) population

Systemic and ocular determinants of peripapillary retinal nerve fiber layer thickness measurements in the European Eye Epidemiology (e3) population
Systemic and ocular determinants of peripapillary retinal nerve fiber layer thickness measurements in the European Eye Epidemiology (e3) population

Purpose: To investigate systemic and ocular determinants of peripapillary retinal nerve fiber layer thickness (pRNFLT) in the European population. Design: Cross-sectional meta-analysis. Participants: A total of 16 084 European adults from 8 cohort studies (mean age range, 56.9±12.3–82.1±4.2 years) of the European Eye Epidemiology (E3) consortium. Methods: We examined associations with pRNFLT measured by spectral-domain OCT in each study using multivariable linear regression and pooled results using random effects meta-analysis. Main Outcome Measures: Determinants of pRNFLT. Results: Mean pRNFLT ranged from 86.8±21.4 μm in the Rotterdam Study I to 104.7±12.5 μm in the Rotterdam Study III. We found the following factors to be associated with reduced pRNFLT: Older age (β = –0.38 μm/year; 95% confidence interval [CI], –0.57 to –0.18), higher intraocular pressure (IOP) (β = –0.36 μm/mmHg; 95% CI, –0.56 to –0.15), visual impairment (β = –5.50 μm; 95% CI, –9.37 to –1.64), and history of systemic hypertension (β = –0.54 μm; 95% CI, –1.01 to –0.07) and stroke (β = –1.94 μm; 95% CI, –3.17 to –0.72). A suggestive, albeit nonsignificant, association was observed for dementia (β = –3.11 μm; 95% CI, –6.22 to 0.01). Higher pRNFLT was associated with more hyperopic spherical equivalent (β = 1.39 μm/diopter; 95% CI, 1.19–1.59) and smoking (β = 1.53 μm; 95% CI, 1.00–2.06 for current smokers compared with never-smokers). Conclusions: In addition to previously described determinants such as age and refraction, we found that systemic vascular and neurovascular diseases were associated with reduced pRNFLT. These may be of clinical relevance, especially in glaucoma monitoring of patients with newly occurring vascular comorbidities.

0161-6420
1526-1536
Mauschitz, Matthias M.
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European Eye Epidemiology (E3) Consortium
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Bonnemaijer, Pieter W.M.
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Loeffler, Markus
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Capuano, Vittorio
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Carrière, Isabelle
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European Eye Epidemiology (E3) Consortium (2018) Systemic and ocular determinants of peripapillary retinal nerve fiber layer thickness measurements in the European Eye Epidemiology (e3) population. Ophthalmology, 125 (10), 1526-1536. (doi:10.1016/j.ophtha.2018.03.026).

Record type: Article

Abstract

Purpose: To investigate systemic and ocular determinants of peripapillary retinal nerve fiber layer thickness (pRNFLT) in the European population. Design: Cross-sectional meta-analysis. Participants: A total of 16 084 European adults from 8 cohort studies (mean age range, 56.9±12.3–82.1±4.2 years) of the European Eye Epidemiology (E3) consortium. Methods: We examined associations with pRNFLT measured by spectral-domain OCT in each study using multivariable linear regression and pooled results using random effects meta-analysis. Main Outcome Measures: Determinants of pRNFLT. Results: Mean pRNFLT ranged from 86.8±21.4 μm in the Rotterdam Study I to 104.7±12.5 μm in the Rotterdam Study III. We found the following factors to be associated with reduced pRNFLT: Older age (β = –0.38 μm/year; 95% confidence interval [CI], –0.57 to –0.18), higher intraocular pressure (IOP) (β = –0.36 μm/mmHg; 95% CI, –0.56 to –0.15), visual impairment (β = –5.50 μm; 95% CI, –9.37 to –1.64), and history of systemic hypertension (β = –0.54 μm; 95% CI, –1.01 to –0.07) and stroke (β = –1.94 μm; 95% CI, –3.17 to –0.72). A suggestive, albeit nonsignificant, association was observed for dementia (β = –3.11 μm; 95% CI, –6.22 to 0.01). Higher pRNFLT was associated with more hyperopic spherical equivalent (β = 1.39 μm/diopter; 95% CI, 1.19–1.59) and smoking (β = 1.53 μm; 95% CI, 1.00–2.06 for current smokers compared with never-smokers). Conclusions: In addition to previously described determinants such as age and refraction, we found that systemic vascular and neurovascular diseases were associated with reduced pRNFLT. These may be of clinical relevance, especially in glaucoma monitoring of patients with newly occurring vascular comorbidities.

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More information

Accepted/In Press date: 15 March 2018
e-pub ahead of print date: 30 April 2018
Published date: 1 October 2018

Identifiers

Local EPrints ID: 438731
URI: http://eprints.soton.ac.uk/id/eprint/438731
ISSN: 0161-6420
PURE UUID: a7784829-20e5-40cb-8c86-da9d68bc97d1
ORCID for Andrew Lotery: ORCID iD orcid.org/0000-0001-5541-4305

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Date deposited: 23 Mar 2020 17:31
Last modified: 26 Nov 2021 02:47

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Contributors

Author: Matthias M. Mauschitz
Author: Pieter W.M. Bonnemaijer
Author: Kersten Diers
Author: Franziska G. Rauscher
Author: Tobias Elze
Author: Christoph Engel
Author: Markus Loeffler
Author: Johanna Maria Colijn
Author: M. Arfan Ikram
Author: Johannes R. Vingerling
Author: Katie M. Williams
Author: Christopher J. Hammond
Author: Catherine Creuzot-Garcher
Author: Alain M. Bron
Author: Rufino Silva
Author: Sandrina Nunes
Author: Cécile Delcourt
Author: Audrey Cougnard-Grégoire
Author: Frank Holz
Author: Caroline C.W. Klaver
Author: Monique M.B. Breteler
Author: Robert P. Finger
Author: Niyazi Acar
Author: Eleftherios Anastosopoulos
Author: Augusto Azuara-Blanco
Author: Tos Berendschot
Author: Arthur Bergen
Author: Geir Bertelsen
Author: Christine Binquet
Author: Alan Bird
Author: Martin Bobak
Author: Morten Bøgelund Larsen
Author: Camiel Boon
Author: Rupert Bourne
Author: Lionel Brétillon
Author: Rebecca Broe
Author: Alain Bron
Author: Gabrielle Buitendijk
Author: Maria Luz Cachulo
Author: Vittorio Capuano
Author: Isabelle Carrière
Author: Usha Chakravarthy
Author: Michelle Chan
Author: Petrus Chang
Author: Johanna Colijn
Author: Audrey Cougnard-Grégoire
Author: Angela Cree
Author: Catherine Creuzot-Garcher
Author: Paul Foster
Author: Andrew Lotery ORCID iD
Corporate Author: European Eye Epidemiology (E3) Consortium

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