Maternal pregnancy vitamin D supplementation increases offspring bone formation in response to mechanical loading: Findings from a MAVIDOS Trial sub-study
Maternal pregnancy vitamin D supplementation increases offspring bone formation in response to mechanical loading: Findings from a MAVIDOS Trial sub-study
The Maternal Vitamin D Osteoporosis (MAVIDOS) trial reported higher total body bone mineral content in winter-born infants of mothers receiving vitamin D supplementation [1000 IU/day cholecalciferol] compared with placebo from 14 weeks gestation until delivery. This sub-study aimed to determine whether antenatal vitamin D supplementation altered postnatal bone formation in response to mechanical stimulation. Thirty-one children born to MAVIDOS participants randomised to either placebo (n=19) or cholecalciferol (n=12) were recruited at age 4-5 years. Children received whole body vibration (WBV) for 10 minutes on 5 consecutive days. Fasting blood samples for bone homeostasis, 25 hydroxyvitamin D (25OHD), parathyroid hormone (PTH), and bone turnover markers (Pro-collagen Type 1 N-terminal propeptide, P1NP; Cross-linked C-telopeptide of Type I Collagen, CTX) were collected pre-WBV and on day 8 (D8). Mean changes (D) in P1NP (ng/ml) between baseline and D8 in the vitamin-D intervention and placebo groups were 40.6 and -92.6 respectively and mean changes (Δ) in CTX (ng/ml) were 0.034 (intervention) and -0.084 (placebo) respectively. Between-group DP1NP difference was 133.2ng/ml [95% CI 0.4, 266.0; p=0.049] and ΔCTX 0.05ng/ml (95% CI -0.159, 0.26ng/mL; p=0.62). Antenatal vitamin-D supplementation resulted in increased P1NP in response to WBV, suggesting early life vitamin D supplementation increases the anabolic response of bone to mechanical loading in children.
Bone Turnover Markers, MAVIDOS, Mechanical Stimulation, Vitamin D, Whole Body Vibration
4-11
Gopal-Kothandapani, J S
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Rigby, A.S.
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Harrison, Rachel
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Eastell, Richard
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Moon, Rebecca
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Curtis, Elizabeth
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Cooper, Cyrus
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Harvey, Nicholas
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Bishop, Nicholas
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March 2020
Gopal-Kothandapani, J S
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Rigby, A.S.
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Harrison, Rachel
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Eastell, Richard
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Moon, Rebecca
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Curtis, Elizabeth
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Cooper, Cyrus
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Harvey, Nicholas
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Bishop, Nicholas
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Gopal-Kothandapani, J S, Rigby, A.S., Harrison, Rachel, Eastell, Richard, Moon, Rebecca, Curtis, Elizabeth, Cooper, Cyrus, Harvey, Nicholas and Bishop, Nicholas
(2020)
Maternal pregnancy vitamin D supplementation increases offspring bone formation in response to mechanical loading: Findings from a MAVIDOS Trial sub-study.
Journal of Musculoskeletal and Neuronal Interactions, 20 (1), .
Abstract
The Maternal Vitamin D Osteoporosis (MAVIDOS) trial reported higher total body bone mineral content in winter-born infants of mothers receiving vitamin D supplementation [1000 IU/day cholecalciferol] compared with placebo from 14 weeks gestation until delivery. This sub-study aimed to determine whether antenatal vitamin D supplementation altered postnatal bone formation in response to mechanical stimulation. Thirty-one children born to MAVIDOS participants randomised to either placebo (n=19) or cholecalciferol (n=12) were recruited at age 4-5 years. Children received whole body vibration (WBV) for 10 minutes on 5 consecutive days. Fasting blood samples for bone homeostasis, 25 hydroxyvitamin D (25OHD), parathyroid hormone (PTH), and bone turnover markers (Pro-collagen Type 1 N-terminal propeptide, P1NP; Cross-linked C-telopeptide of Type I Collagen, CTX) were collected pre-WBV and on day 8 (D8). Mean changes (D) in P1NP (ng/ml) between baseline and D8 in the vitamin-D intervention and placebo groups were 40.6 and -92.6 respectively and mean changes (Δ) in CTX (ng/ml) were 0.034 (intervention) and -0.084 (placebo) respectively. Between-group DP1NP difference was 133.2ng/ml [95% CI 0.4, 266.0; p=0.049] and ΔCTX 0.05ng/ml (95% CI -0.159, 0.26ng/mL; p=0.62). Antenatal vitamin-D supplementation resulted in increased P1NP in response to WBV, suggesting early life vitamin D supplementation increases the anabolic response of bone to mechanical loading in children.
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JMNI MAVIDOS WBV paper-Proof
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Accepted/In Press date: 16 February 2020
e-pub ahead of print date: 3 March 2020
Published date: March 2020
Additional Information:
Funding Information:
JSG-K, ASR, RCH, RJM, EMC, have nothing to disclose. CC reports personal fees from ABBH, AMGEN, Eli Lilly, GSK, Medtronic, Merck, Novartis, Pfzer, Roche, Servier and Takeda, outside the submitted work. NCH reports personal fees, consultancy, lecture fees and honoraria from Alliance for Better Bone Health, AMGEN, MSD, Eli Lilly, Servier, Shire, Consilient Healthcare and Internis Pharma, outside the submitted work. RE reports consulting fees from Amgen, AstraZeneca, Chronos, GSK, Immunodiagnostic Systems, Fonterra Brands, Ono Pharma, Lilly, Bayer, Janssen Research, Alere, CL Biosystems, Teijin Pharm, D-Star, Roche Diagnostics, Inverness Medical; grant support from Amgen, Alexion, Immunodiagnostic Systems, Roche, AstraZeneca. NJB reports personal fees from Internis, grants and personal fees from Alexion Pharma, personal fees from Mereo Biopharma, grants and personal fees from Amgen, personal fees from Novartis, outside the submitted work.
Publisher Copyright:
© 2020, International Society of Musculoskeletal and Neuronal Interactions. All rights reserved.
Keywords:
Bone Turnover Markers, MAVIDOS, Mechanical Stimulation, Vitamin D, Whole Body Vibration
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Local EPrints ID: 438787
URI: http://eprints.soton.ac.uk/id/eprint/438787
ISSN: 1108-7161
PURE UUID: 4c0d5105-f991-482d-a773-5b6dc598332a
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Date deposited: 24 Mar 2020 17:31
Last modified: 18 Mar 2024 03:38
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Contributors
Author:
J S Gopal-Kothandapani
Author:
A.S. Rigby
Author:
Rachel Harrison
Author:
Richard Eastell
Author:
Rebecca Moon
Author:
Nicholas Bishop
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