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Maternal pregnancy vitamin D supplementation increases offspring bone formation in response to mechanical loading: Findings from a MAVIDOS Trial sub-study

Maternal pregnancy vitamin D supplementation increases offspring bone formation in response to mechanical loading: Findings from a MAVIDOS Trial sub-study
Maternal pregnancy vitamin D supplementation increases offspring bone formation in response to mechanical loading: Findings from a MAVIDOS Trial sub-study
The Maternal Vitamin D Osteoporosis (MAVIDOS) trial reported higher total body bone mineral content in winter-born infants of mothers receiving vitamin D supplementation [1000 IU/day cholecalciferol] compared with placebo from 14 weeks gestation until delivery. This sub-study aimed to determine whether antenatal vitamin D supplementation altered postnatal bone formation in response to mechanical stimulation. Thirty-one children born to MAVIDOS participants randomised to either placebo (n=19) or cholecalciferol (n=12) were recruited at age 4-5 years. Children received whole body vibration (WBV) for 10 minutes on 5 consecutive days. Fasting blood samples for bone homeostasis, 25 hydroxyvitamin D (25OHD), parathyroid hormone (PTH), and bone turnover markers (Pro-collagen Type 1 N-terminal propeptide, P1NP; Cross-linked C-telopeptide of Type I Collagen, CTX) were collected pre-WBV and on day 8 (D8). Mean changes (D) in P1NP (ng/ml) between baseline and D8 in the vitamin-D intervention and placebo groups were 40.6 and -92.6 respectively and mean changes (Δ) in CTX (ng/ml) were 0.034 (intervention) and -0.084 (placebo) respectively. Between-group DP1NP difference was 133.2ng/ml [95% CI 0.4, 266.0; p=0.049] and ΔCTX 0.05ng/ml (95% CI -0.159, 0.26ng/mL; p=0.62). Antenatal vitamin-D supplementation resulted in increased P1NP in response to WBV, suggesting early life vitamin D supplementation increases the anabolic response of bone to mechanical loading in children.
1108-7161
Gopal-Kothandapani, J S
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Rigby, A.S.
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Harrison, Rachel
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Eastell, Richard
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Moon, Rebecca
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Curtis, Elizabeth
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Cooper, Cyrus
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Harvey, Nicholas
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Bishop, Nicholas
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Gopal-Kothandapani, J S
f3dd06f1-3eb2-43a0-b83f-c7160b9e7a44
Rigby, A.S.
fb6c10e5-9f11-4ffe-9699-3f0505e63455
Harrison, Rachel
a2bce6a7-852b-48e7-a816-d1e50cd97c56
Eastell, Richard
b19615e4-bc97-4ddf-b8d7-7f48b7220228
Moon, Rebecca
954fb3ed-9934-4649-886d-f65944985a6b
Curtis, Elizabeth
12aba0c3-1e9e-49ef-a7e9-3247e649cdd6
Cooper, Cyrus
e05f5612-b493-4273-9b71-9e0ce32bdad6
Harvey, Nicholas
ce487fb4-d360-4aac-9d17-9466d6cba145
Bishop, Nicholas
27b4739b-c34e-4db5-af30-10ef7e25bfd7

Gopal-Kothandapani, J S, Rigby, A.S., Harrison, Rachel, Eastell, Richard, Moon, Rebecca, Curtis, Elizabeth, Cooper, Cyrus, Harvey, Nicholas and Bishop, Nicholas (2020) Maternal pregnancy vitamin D supplementation increases offspring bone formation in response to mechanical loading: Findings from a MAVIDOS Trial sub-study. Journal of Musculoskeletal and Neuronal Interactions, 20 (1).

Record type: Article

Abstract

The Maternal Vitamin D Osteoporosis (MAVIDOS) trial reported higher total body bone mineral content in winter-born infants of mothers receiving vitamin D supplementation [1000 IU/day cholecalciferol] compared with placebo from 14 weeks gestation until delivery. This sub-study aimed to determine whether antenatal vitamin D supplementation altered postnatal bone formation in response to mechanical stimulation. Thirty-one children born to MAVIDOS participants randomised to either placebo (n=19) or cholecalciferol (n=12) were recruited at age 4-5 years. Children received whole body vibration (WBV) for 10 minutes on 5 consecutive days. Fasting blood samples for bone homeostasis, 25 hydroxyvitamin D (25OHD), parathyroid hormone (PTH), and bone turnover markers (Pro-collagen Type 1 N-terminal propeptide, P1NP; Cross-linked C-telopeptide of Type I Collagen, CTX) were collected pre-WBV and on day 8 (D8). Mean changes (D) in P1NP (ng/ml) between baseline and D8 in the vitamin-D intervention and placebo groups were 40.6 and -92.6 respectively and mean changes (Δ) in CTX (ng/ml) were 0.034 (intervention) and -0.084 (placebo) respectively. Between-group DP1NP difference was 133.2ng/ml [95% CI 0.4, 266.0; p=0.049] and ΔCTX 0.05ng/ml (95% CI -0.159, 0.26ng/mL; p=0.62). Antenatal vitamin-D supplementation resulted in increased P1NP in response to WBV, suggesting early life vitamin D supplementation increases the anabolic response of bone to mechanical loading in children.

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JMNI MAVIDOS WBV paper-Proof - Accepted Manuscript
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Accepted/In Press date: 16 February 2020
e-pub ahead of print date: 3 March 2020

Identifiers

Local EPrints ID: 438787
URI: http://eprints.soton.ac.uk/id/eprint/438787
ISSN: 1108-7161
PURE UUID: 4c0d5105-f991-482d-a773-5b6dc598332a
ORCID for Elizabeth Curtis: ORCID iD orcid.org/0000-0002-5147-0550
ORCID for Cyrus Cooper: ORCID iD orcid.org/0000-0003-3510-0709
ORCID for Nicholas Harvey: ORCID iD orcid.org/0000-0002-8194-2512

Catalogue record

Date deposited: 24 Mar 2020 17:31
Last modified: 07 Oct 2020 02:13

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Contributors

Author: J S Gopal-Kothandapani
Author: A.S. Rigby
Author: Rachel Harrison
Author: Richard Eastell
Author: Rebecca Moon
Author: Cyrus Cooper ORCID iD
Author: Nicholas Harvey ORCID iD
Author: Nicholas Bishop

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