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Low susceptibility of resident microglia to simian immunodeficiency virus replication during the early stages of infection

Low susceptibility of resident microglia to simian immunodeficiency virus replication during the early stages of infection
Low susceptibility of resident microglia to simian immunodeficiency virus replication during the early stages of infection

To assess the susceptibility of resident microglia to simian immunodeticiency virus (SIV) infection, we analysed the hrains of rhesus macaques after intracerebral (i.c.1 inoculation of the virus into the central region at 7 days, 1, 2 and 3 months post‐inoculation (p.i.). The brains of animals showed the same moderate neuro‐pathological changes in central, frontal and parietal regions of the brain. characterized by gliosis, microglial nodules, perivascular infiltrates and occasional white matter pallor and similar low numbers of infected cells detected by in situ hybridization. These results, showing that i.c. inoculation did not lead to preferential infection of brain tissue, even near the inoculation point at 7 days p.i., provide evidence for the low susceptibility of resident microglia to SIV replication during the early stages of infection.

central nervous system, encephalopathy, microglia, rhesus, simian immunodeficiency virus (SIV)
0305-1846
535-539
Boche, D.
bdcca10e-6302-4dd0-919f-67218f7e0d61
Gray, F.
4cccaf57-4e3a-4c55-9ab4-870e47a06947
Chakrabarti, L.
d65e4d3b-5bb7-4c95-82cb-cf98a021ef46
Hurtrel, M.
9641f3f9-ddbf-44dc-9300-07689bbefc6c
Montagnier, L.
80c2ecb7-a62e-4b81-a1dd-5438bc61f05f
Hurtrel, B.
6798d5fc-3ad6-431f-89d7-f269f9a17c4f
Boche, D.
bdcca10e-6302-4dd0-919f-67218f7e0d61
Gray, F.
4cccaf57-4e3a-4c55-9ab4-870e47a06947
Chakrabarti, L.
d65e4d3b-5bb7-4c95-82cb-cf98a021ef46
Hurtrel, M.
9641f3f9-ddbf-44dc-9300-07689bbefc6c
Montagnier, L.
80c2ecb7-a62e-4b81-a1dd-5438bc61f05f
Hurtrel, B.
6798d5fc-3ad6-431f-89d7-f269f9a17c4f

Boche, D., Gray, F., Chakrabarti, L., Hurtrel, M., Montagnier, L. and Hurtrel, B. (1995) Low susceptibility of resident microglia to simian immunodeficiency virus replication during the early stages of infection. Neuropathology and Applied Neurobiology, 21 (6), 535-539. (doi:10.1111/j.1365-2990.1995.tb01100.x).

Record type: Article

Abstract

To assess the susceptibility of resident microglia to simian immunodeticiency virus (SIV) infection, we analysed the hrains of rhesus macaques after intracerebral (i.c.1 inoculation of the virus into the central region at 7 days, 1, 2 and 3 months post‐inoculation (p.i.). The brains of animals showed the same moderate neuro‐pathological changes in central, frontal and parietal regions of the brain. characterized by gliosis, microglial nodules, perivascular infiltrates and occasional white matter pallor and similar low numbers of infected cells detected by in situ hybridization. These results, showing that i.c. inoculation did not lead to preferential infection of brain tissue, even near the inoculation point at 7 days p.i., provide evidence for the low susceptibility of resident microglia to SIV replication during the early stages of infection.

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More information

Published date: December 1995
Keywords: central nervous system, encephalopathy, microglia, rhesus, simian immunodeficiency virus (SIV)

Identifiers

Local EPrints ID: 438802
URI: http://eprints.soton.ac.uk/id/eprint/438802
ISSN: 0305-1846
PURE UUID: bfa4b859-8cb9-46b1-b6e9-7e17f2c6a249
ORCID for D. Boche: ORCID iD orcid.org/0000-0002-5884-130X

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Date deposited: 24 Mar 2020 17:52
Last modified: 07 Oct 2020 01:44

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