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Progressive multifocal leukoencephalopathy and oligodendroglioma in a monkey co-infected by simian immunodeficiency virus and simian virus 40

Progressive multifocal leukoencephalopathy and oligodendroglioma in a monkey co-infected by simian immunodeficiency virus and simian virus 40
Progressive multifocal leukoencephalopathy and oligodendroglioma in a monkey co-infected by simian immunodeficiency virus and simian virus 40

A rhesus monkey experimentally inoculated with simian immunodeficiency virus (SIV) mac251 was killed 42 months later because of poor general condition. CD4 lymphocyte count which was 3,430/mm3 before inoculation, had decreased to 638/mm3 2 months before death. Neuropathological examination revealed changes characteristic of progressive multifocal leukoencephalopathy (PML) in the white matter of the cerebral hemispheres and brain stem. In situ hybridization was negative for JC virus but markedly positive for simian virus 40 (SV40) in the nuclei of many oligodendrocytes. Many oligodendrocytes also expressed p53. Within an area involved by PML, there was a densely cellular tumor with honeycomb appearance and elongated vessels characteristic of oligodendrogliomas. Within the tumor in situ hybridization for SV40 and immunocytochemistry for p53 were negative. Opportunistic infection by SV40 has been occasionally reported in experimentally SIV-infected monkeys resulting in PML or malignant astrocytoma. Association of JC virus-induced PML and astrocytomas has been reported in three human cases without AIDS. In those cases, as in our monkey, polyomaviruses (SV40 or JC virus) were expressed in the areas with PML but not in the glial tumor. Association of PML and oligodendroglioma has not been reported previously to our knowledge. The relationship between oligodendrocyte proliferation and polyomavirus infection of oligodendrocytes is unclear. Our findings suggest that binding of the viral protein to p53 may result in inactivation of the pro-apoptotic protein favoring the proliferation of a randomly occurring tumoral clone of oligodendrocytes.

Oligodendroglioma, p53, Progressive multifocal leukoencephalopathy, Simian immunodeficiency virus, Simian virus 40
0001-6322
332-336
Chrétien, Fabrice
3e9f581a-13f1-42e0-886c-bbff876133c2
Boche, Delphine
bdcca10e-6302-4dd0-919f-67218f7e0d61
De La Grandmaison, Geoffroy Lorin
c15f63b8-3cff-43cd-8753-14a6e0bd62c8
Ereau, Thierry
82f7f750-a7d9-4f54-a946-c1125de87fc1
Mikol, Jacqueline
fbbe5c69-4571-4a49-b0a8-e9c6d06a8098
Hurtrel, Maryse
9641f3f9-ddbf-44dc-9300-07689bbefc6c
Hurtrel, Bruno
6798d5fc-3ad6-431f-89d7-f269f9a17c4f
Gray, Françoise
d51d9569-90d8-4b13-8e36-4dc5372b50b5
Chrétien, Fabrice
3e9f581a-13f1-42e0-886c-bbff876133c2
Boche, Delphine
bdcca10e-6302-4dd0-919f-67218f7e0d61
De La Grandmaison, Geoffroy Lorin
c15f63b8-3cff-43cd-8753-14a6e0bd62c8
Ereau, Thierry
82f7f750-a7d9-4f54-a946-c1125de87fc1
Mikol, Jacqueline
fbbe5c69-4571-4a49-b0a8-e9c6d06a8098
Hurtrel, Maryse
9641f3f9-ddbf-44dc-9300-07689bbefc6c
Hurtrel, Bruno
6798d5fc-3ad6-431f-89d7-f269f9a17c4f
Gray, Françoise
d51d9569-90d8-4b13-8e36-4dc5372b50b5

Chrétien, Fabrice, Boche, Delphine, De La Grandmaison, Geoffroy Lorin, Ereau, Thierry, Mikol, Jacqueline, Hurtrel, Maryse, Hurtrel, Bruno and Gray, Françoise (2000) Progressive multifocal leukoencephalopathy and oligodendroglioma in a monkey co-infected by simian immunodeficiency virus and simian virus 40. Acta Neuropathologica, 100 (3), 332-336. (doi:10.1007/s004010050031).

Record type: Article

Abstract

A rhesus monkey experimentally inoculated with simian immunodeficiency virus (SIV) mac251 was killed 42 months later because of poor general condition. CD4 lymphocyte count which was 3,430/mm3 before inoculation, had decreased to 638/mm3 2 months before death. Neuropathological examination revealed changes characteristic of progressive multifocal leukoencephalopathy (PML) in the white matter of the cerebral hemispheres and brain stem. In situ hybridization was negative for JC virus but markedly positive for simian virus 40 (SV40) in the nuclei of many oligodendrocytes. Many oligodendrocytes also expressed p53. Within an area involved by PML, there was a densely cellular tumor with honeycomb appearance and elongated vessels characteristic of oligodendrogliomas. Within the tumor in situ hybridization for SV40 and immunocytochemistry for p53 were negative. Opportunistic infection by SV40 has been occasionally reported in experimentally SIV-infected monkeys resulting in PML or malignant astrocytoma. Association of JC virus-induced PML and astrocytomas has been reported in three human cases without AIDS. In those cases, as in our monkey, polyomaviruses (SV40 or JC virus) were expressed in the areas with PML but not in the glial tumor. Association of PML and oligodendroglioma has not been reported previously to our knowledge. The relationship between oligodendrocyte proliferation and polyomavirus infection of oligodendrocytes is unclear. Our findings suggest that binding of the viral protein to p53 may result in inactivation of the pro-apoptotic protein favoring the proliferation of a randomly occurring tumoral clone of oligodendrocytes.

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More information

Published date: July 2000
Keywords: Oligodendroglioma, p53, Progressive multifocal leukoencephalopathy, Simian immunodeficiency virus, Simian virus 40

Identifiers

Local EPrints ID: 438805
URI: http://eprints.soton.ac.uk/id/eprint/438805
ISSN: 0001-6322
PURE UUID: 108ec440-9e33-493a-8513-4b2df79258bc
ORCID for Delphine Boche: ORCID iD orcid.org/0000-0002-5884-130X

Catalogue record

Date deposited: 24 Mar 2020 17:52
Last modified: 25 Mar 2020 01:27

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